Calmodulin (CALM2) (NM_001743) Human Untagged Clone

CAT#: SC119076

CALM2 (untagged)-Human calmodulin 2 (phosphorylase kinase, delta) (CALM2)


  "NM_001743" in other vectors (6)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CALM2
Synonyms CALM; CALML2; caM; CAM1; CAM3; CAMC; CAMII; CAMIII; LQT15; PHKD; PHKD2
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_001743 edited
GAATTCGGCACGAGGGCGAGCTGAGTGGTTGTGTGGTCGCGTCTCGGAAACCGGTAGCGC
TTGCAGCATGGCTGACCAACTGACTGAAGAGCAGATTGCAGAATTCAAAGAAGCTTTTTC
ACTATTTGACAAAGATGGTGATGGAACTATAACAACAAAGGAATTGGGAACTGTAATGAG
ATCTCTTGGGCAGAATCCCACAGAAGCAGAGTTACAGGACATGATTAATGAAGTAGATGC
TGATGGTAATGGCACAATTGACTTCCCTGAATTTCTGACAATGATGGCAAGAAAAATGAA
AGACACAGACAGTGAAGAAGAAATTAGAGAAGCATTCCGTGTGTTTGATAAGGATGGCAA
TGGCTATATTAGTGCTGCAGAACTTCGCCATGTGATGACAAACCTTGGAGAGAAGTTAAC
AGATGAAGAAGTTGATGAAATGATCAGGGAAGCAGATATTGATGGTGATGGTCAAGTAAA
CTATGAAGAGTTTGTACAAATGATGACAGCAAAGTGAAGACCTTGTACAGAATGTGTTAA
ATTTCTTGTACAAAATTGTTTATTTGCCTTTTCTTTGTTTGTAACTTATCTGTAAAAGGT
TTCTCCCTACTGTCAAAAAAATATGCATGTATAGTAATTAGGACTTCATTCCTCCATGTT
TTCTTCCCTTATCTTACTGTCATTGTCCTAAAACCTTATTTTAGAAAATTGATCAAGTAA
CATGTTGCATGTGGCTTACTCTGGATATATCTAAGCCCTTCTGCACATCTAAACTTAGAT
GGAGTTGGTCAAATGAGGGAACATCTGGGTTATGCCTTTTTTAAAGTAGTTTTCTTTAGG
AACTGTCAGCATGTTGTTGTTGAAGTGTGGAGTTGTAACTCTGCGTGGACTATGGACAGT
CAACAATATGTACTTAAAAGTTGCACTATTGCAAAACGGGTGTATTATCCAGGTACTCGT
ACACTATTTTTTTGTACTGCTGGTCCTGTACCAGAAACATTTTCTTTTATTGTTACTTGC
TTTTTAAACTTTGTTTAGCCACTTAAAATCTGCTTATGGCACAATTTGCCTCAAAATCCA
TTCCAAGTTGTATATTTGTTTTCCAATAAAAAAATTACAATTTACCCAAAAAAAAAAAAA
AAAAACTCGAC
>OriGene 5' read for NM_001743 unedited
ATTTTGTAATACGACTTANCTATAGGGCGGCCGCGAATTCGCACGAGGGCGAGCTGATTG
GTTGTGTGGTCGCGTCTCGGAAACCGGTAGCGCTTGCAGCATGGCTGACCAACTGACTGA
AGAGCAGATTGCAGAATTCAAAGAAGCTTTTTCACTATTTGACAAAGATGGTGATGGAAC
TATAACAACAAAGGAATTGGGAACTGTATTTATATCTCTTGGGCAGAATCCCACAGAAGC
AGAGTTACAGGACATGATTAATGAAGTAGATGCTGATGGTAATGGCACAATTGACTTCCC
TGAATTTCTGACAATGATGGCAAGAAAAATGAAAGACACAGACAGTGAAGAAGAAATTAG
AGAAGCATTCCGTGTGTTTGATAAGGATGGCAATGGCTATATTAGTGCTGCAGAACTTCG
CCATGTGATGACAAACCTTGGAGAGAAGTTAACAGATGAAGAAGTTGATGAAATGATCAG
GGAAGCAGATATTGATGGTGATGGTCAAGTAAACTATGAAGAGTTTGTACAAATGATGAC
AGCAAAGTGAAGACCTTGTACAGAATGTGTTAAATTTCTTGTACAAAATTGTTTATTTGC
CTTTTCTTTGTTTGTAACTTATCTGTAAAAGGTTTCTCCCTACTGTCAAAAAAATATGCA
TGTATAGTAATTAGGACTTCATTCCTCCATGTTTTCTTCCCTTATCTTACTGTCATTGTC
CTAAAACCTTATTTTAGAANATTGATCAAGTAACATGTTGCATGTGGCTTACTCTGGATA
TATCTAAGCCCTTCTGCACATCTAAACTTAAATGGAGNTGGTCAAATGAGGGAAACATCT
GGNTATGCCTTTTTTTAAGTAAGTTTCTTAGGAACTGTCACCATGNTGTTGTTGAAGTGT
GGAGTTGAACTCTGCGTGGACTATGGCAGCCACCATATGTACTTAAAAGTGCACTATGCA
AACGGTTGATNATCCAGGACTT
>OriGene 3' read for NM_001743 unedited
TTTCCCCCCCCCTCCNCCCCTCCNCTTCCCTTACCTTGTAAGCGGCCGCAATCTACATCG
AGTTTTTTTTTTTTTTTTTTGGGTAAATTGTAATTTTTTTATTGGAAAACAAATATACAA
CTTGCGAAGGATTTTGAGGCAAATTGTGCCATAAGCAGATTTTAAGTGGCTAAACAAAGT
TTAAAAAGCAAGTAACAATAAAAGAAAATGTTTCTGGTACAGGACCAGCAGTACAAAAAA
ATAGTGTACGAGTACCTGGATAATACACCCGTTTTGCAATAGTGCAACTTTTAAGTACAT
ATTGTTGACTGTCCATAGTCCACGCAGAGTTACAACTCCACACTTCAACAACAACATGCT
GACAGTTCCTAAAGAAAACTACTTTAAAAAAGGCATAACCCAGATGTTCCCTCATTTGAC
CAACTCCATCTAAGTTTAGATGTGCAGAAGGGCTTATATATATCCAGAGTAAGCCACATG
CAACATGTTACTTGATCAATTTTCTAAAATAAGGCTTTAGGACAATGACAGCAAGATAAG
GGAAGAAAACATGGAGGAATGAAGCCCTAATTACTATACATGCATATTTTTTTGACAGTA
GGGAGAAACCTTTTACAGATAAGTTACAAACACAGAAAAGGCAAATAAACAATTTTGTTC
CAGAAAATTAACACATTCTGTACAAGTCCTTAACTTTGGTGTCATTATTTTGTACAAACT
TTTTATTAGTTTACTTGACCATCACCATTAATATCTGCTTCCCTGATATTTCAATAAACT
TTTAATCCGTTAACCTCTCTTCAAGGTTTTGTTATACAATTGCCCAAAGTTCTTTAACCA
CTAATAATACCCATTGGCCTTCCCTATTCAAACACACCGGAAAGCCTCCCCTAATTCCTT
TCTCAACGGCCTGGGCCTCTTCATTTTTCTTTGCCACTCTTTGCACAGAAT
Restriction Sites NotI-NotI     
ACCN NM_001743
Insert Size 1160 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001743.3, NP_001734.1
RefSeq Size 1128 bp
RefSeq ORF 450 bp
Locus ID 805
Cytogenetics 2p21
Domains EFh
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Calcium signaling pathway, Glioma, GnRH signaling pathway, Insulin signaling pathway, Long-term potentiation, Melanogenesis, Neurotrophin signaling pathway, Olfactory transduction, Oocyte meiosis, Phosphatidylinositol signaling system, Vascular smooth muscle contraction
Gene Summary 'This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]'
Transcript Variant: This variant (2) lacks an exon in the 5' coding region, and uses an alternate start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1, and is the same protein encoded by other calmodulin gene family members.

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