IL12RB2 (NM_001559) Human Untagged Clone

CAT#: SC119132

IL12RB2 (untagged)-Human interleukin 12 receptor, beta 2 (IL12RB2)


  "NM_001559" in other vectors (6)

Reconstitution Protocol

USD 760.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol IL12RB2
Synonyms RP11-102M16.1
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_001559 edited
ATGGCACATACTTTTAGAGGATGCTCATTGGCATTTATGTTTATAATCACGTGGCTGTTG
ATTAAAGCAAAAATAGATGCGTGCAAGAGAGGCGATGTGACTGTGAAGCCTTCCCATGTA
ATTTTACTTGGATCCACTGTCAATATTACATGCTCTTTGAAGCCCAGACAAGGCTGCTTT
CACTATTCCAGACGTAACAAGTTAATCCTGTACAAGTTTGACAGAAGAATCAATTTTCAC
CATGGCCACTCCCTCAATTCTCAAGTCACAGGTCTTCCCCTTGGTACAACCTTGTTTGTC
TGCAAACTGGCCTGTATCAATAGTGATGAAATTCAAATATGTGGAGCAGAGATCTTCGTT
GGTGTTGCTCCAGAACAGCCTCAAAATTTATCCTGCATACAGAAGGGAGAACAGGGGACT
GTGGCCTGCACCTGGGAAAGAGGACGAGACACCCACTTATACACTGAGTATACTCTACAG
CTAAGTGGACCAAAAAATTTAACCTGGCAGAAGCAATGTAAAGACATTTATTGTGACTAT
TTGGACTTTGGAATCAACCTCACCCCTGAATCACCTGAATCCAATTTCACAGCCAAGGTT
ACTGCTGTCAATAGTCTTGGAAGCTCCTCTTCACTTCCATCCACATTCACATTCTTGGAC
ATAGTGAGGCCTCTTCCTCCGTGGGACATTAGAATCAAATTTCAAAAGGCTTCCGTGAGC
AGATGTACCCTTTATTGGAGAGATGAGGGACTGGTACTGCTTAATCGACTCAGATATCGG
CCCAGTAACAGCAGGCTCTGGAATATGGTTAATGTTACAAAGGCCAAAGGAAGACATGAT
TTGCTGGATCTGAAACCATTTACAGAATATGAATTTCAGATTTCCTCTAAGCTACATCTT
TATAAGGGAAGTTGGAGTGATTGGAGTGAATCATTGAGAGCACAAACACCAGAAGAAGAG
CCTACTGGGATGTTAGATGTCTGGTACATGAAACGGCACATTGACTACAGTAGACAACAG
ATTTCTCTTTTCTGGAAGAATCTGAGTGTCTCAGAGGCAAGAGGAAAAATTCTCCACTAT
CAGGTGACCTTGCAGGAGCTGACAGGAGGGAAAGCCATGACACAGAACATCACAGGACAC
ACCTCCTGGACCACAGTCATTCCTAGAACCGGAAATTGGGCTGTGGCTGTGTCTGCAGCA
AATTCAAAAGGCAGTTCTCTGCCCACTCGTATTAACATAATGAACCTGTGTGAGGCAGGG
TTGCTGGCTCCTCGCCAGGTCTCTGCAAACTCAGAGGGCATGGACAACATTCTGGTGACT
TGGCAGCCTCCCAGGAAAGATCCCTCTGCTGTTCAGGAGTACGTGGTGGAATGGAGAGAG
CTCCATCCAGGGGGTGACACACAGGTCCCTCTAAACTGGCTACGGAGTCGACCCTACAAT
GTGTCTGCTCTGATTTCAGAGAACATAAAATCCTACATCTGTTATGAAATCCGTGTGTAT
GCACTCTCAGGGGATCAAGGAGGATGCAGCTCCATCCTGGGTAACTCTAAGCACAAAGCA
CCACTGAGTGGCCCCCACATTAATGCCATCACAGAGGAAAAGGGGAGCATTTTAATTTCA
TGGAACAGCATTCCAGTCCAGGAGCAAATGGGCTGCCTCCTCCATTATAGGATATACTGG
AAGGAACGGGACTCCAACTCCCAGCCTCAGCTCTGTGAAATTCCCTACAGAGTCTCCCAA
AATTCACATCCAATAAACAGCCTGCAGCCCCGAGTGACATATGTCCTGTGGATGACAGCT
CTGACAGCTGCTGGTGAAAGTTCCCACGGAAATGAGAGGGAATTTTGTCTGCAAGGTAAA
GCCAATTGGATGGCGTTTGTGGCACCAAGCATTTGCATTGCTATCATCATGGTGGGCATT
TTCTCAACACATTACTTCCAGCAAAAGGTGTTTGTTCTCCTAGCAGCCCTCAGACCTCAG
TGGTGTAGCAGAGAAATTCCAGATCCAGCAAATAGCACTTGCGCTAAGAAATATCCCATT
GCAGAGGAGAAGACACAGCTGCCCTTGGACAGGCTCCTGATAGACTGGCCCACGCCTGAA
GATCCTGAACCGCTGGTCATCAGTGAAGTCCTTCATCAAGTGACCCCAGTTTTCAGACAT
CCCCCCTGCTCCAACTGGCCACAAAGGGAAAAAGGAATCCAAGGTCATCAGGCCTCTGAG
AAAGACATGATGCACAGTGCCTCAAGCCCACCACCTCCAAGAGCTCTCCAAGCTGAGAGC
AGACAACTGGTGGATCTGTACAAGGTGCTGGAGAGCAGGGGCTCCGACCCAAAGCCAGAA
AACCCAGCCTGTCCCTGGACGGTGCTCCCAGCAGGTGACCTTCCCACCCATGATGGCTAC
TTACCCTCCAACATAGATGACCTCCCCTCACATGAGGCACCTCTCGCTGACTCTCTGGAA
GAACTGGAGCCTCAGCACATCTCCCTTTCTGTTTTCCCCTCAAGTTCTCTTCACCCACTC
ACCTTCTCCTGTGGTGATAAGCTGACTCTGGATCAGTTAAAGATGAGGTGTGACTCCCTC
ATGCTCTGA
>OriGene 5' read for NM_001559 unedited
GGTTCACATTTGTATACGACTCACTATAGGCGGCCGCGATTCGGCACGAGGGCGGAGAGC
GCGACACGTGCGGCCCAGAACACCGGGGCCACCCGGTCCCCGCAGGCCCGGGACCGCGCC
CGCTGGCAGGCGACACGTGGTCACGGTGATCCATTTGTAAAGTCGGGAATAAATGACCTC
TGAAGTGTTGTCTGTATATTGATCTGCTACCAGTAAAACATATCTCTGAAGAATACGGAG
TTCTATACCAGAGTTGATTGCTGATGGCACATACTTTTAGAGGATGCTCATTGGCATTTA
TGTTTATAATCACGTGGCTGTTGATTAAAGCAAAAATAGATGCGTGCAAGAGAGGCGATG
TGACTGTGAAGCCTTCCCATGTAATTTTACTTGGATCCACTGTCAATATTACATGCTCTT
TGAAGCCCAGACAAGGCTGCTTTCACTATTCCAGACGTAACAAGTTAATCCTGTACAAGT
TTGACAGAAGAATCAATTTTCACCATGGCCACTCCCTCAATTCTCAAGTCACAGGTCTTC
CCCTTGGTACAACCTTGTTTGTCTGCAAACTCTGCCTGTATCAATAGTGATGAAATTCAA
ATATGTGGAGCAGAGATCTTCGTTGGTGTTGCTCCAGAACAGCCTCAAAATTTATCCTGC
ATACAGAAGGGAGAACAGGGGACTGTGGCCTGCACCTGGGAAAGAGGACGAGACACCCAC
TTATACACTGAGTATACTCTACAGCTAAGTGGACCAAAAAATTTAACCTGGCAGAAGCAA
TGTAAAGACATTTATTGTGACTATTTGGACTTTGGAATCAACCTCANCCCTGAATCACCT
GAAATCCATTTCACAGCCCAAGTTACTGCTACTCATAGTCCTTGGAAGCTCCTCTTTACT
TCCTTCACATTCACATTCTTG
>OriGene 3' read for NM_001559 unedited
TAGCTTTGGACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTCTTTTTT
GAGACAGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCTCACTGCAAGCCCCACC
TCCCAGGTTCATGTCATTCTCCTCCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCC
GCCATCACGCCCAGTTAATTTTTTTTAAAAATATTTTTAGTAGAGATGGGGTTTCACCAT
GTTAGCCAGAATGGTCTCGATCTCCTGACCTCATGATCCGCCTGCCTCAGCCTCCCAAAG
TGCTGGGATTACAGGCATGAGCTACCACGCCCGGCCAGAAAAAGGTACATTCTTAGACTT
CTGCAAATGAGACCAGTCATGACCACCTTGGGGGCCCTTTTACATTGGTGTTTACCAGGG
TCTTTTATGTCTTCATCTATAGAACTAGGTTGATTTGTTTTGAAGGCTCTCAATAATCTA
GGAGCCATCTAGAGCTGTGCACTCCAATACAGTAGCCACTAGCCATGTGTGGCGATTTAA
ATTTACAATCAAAATTTAATTCCTCAGTCAAGCTAAACACATTCCAAGTGATTAACAGCC
AATGTGCCTAGTGTCTAATGTACTGGACAGTGAGTGCAGAGGTAGAACATTTCCATCATC
TCAGGAAGTTCTGTTGAACAGTACTGATCTGCTGTGTACAGCCTGCTGTGTACCAGGTGC
TTTAGAAATATCATTGCATGAATGCCCTCTAGACTGTATGCCATTACTACTAAGAGCTGC
GGCTTCTACCTCTCTCCTCAATTCCCTTTCTGCCCAGCTACCCAGAAAGTACCTAGGATT
CAGCTGGAGTCTTTAGTCCCCCAGTGAAGAGTAATTTAAGCCCTGGGAAGCAAATGAGCA
CTGAGGAAACCACTCCAGTCCTAAACTCCCCAAGCTGTTGCCGGCTT
Restriction Sites NotI-NotI     
ACCN NM_001559
Insert Size 3900 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001559.2, NP_001550.1
RefSeq Size 4040 bp
RefSeq ORF 2589 bp
Locus ID 3595
Cytogenetics 1p31.3
Domains FN3
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
Gene Summary 'The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]'
Transcript Variant: This variant (1) encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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