INPP5F (OCRL) (NM_001587) Human Untagged Clone

CAT#: SC119145

OCRL (untagged)-Human oculocerebrorenal syndrome of Lowe (OCRL), transcript variant b


  "NM_001587" in other vectors (4)

Reconstitution Protocol

USD 760.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol OCRL
Synonyms INPP5F; LOCR; NPHL2; OCRL-1; OCRL1
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_001587 edited
ATGGAGCCGCCGCTCCCGGTCGGAGCCCAGCCGCTTGCCACTGTCGAGGGTATGGAGATG
AAGGGTCCTCTCCGGGAGCCCTGCGCCCTGACCCTAGCCCAGAGGAACGGGCAATATGAG
TTAATAATCCAGTTGCATGAGAAGGAACAGCATGTTCAAGATATCATTCCTATAAATAGC
CACTTCAGATGTGTTCAAGAAGCAGAAGAAACTCTTTTGATTGACATAGCTTCTAACAGT
GGCTGCAAAATTCGGGTTCAGGGGGACTGGATCAGAGAGCGCCGCTTTGAAATCCCTGAT
GAGGAACACTGTTTGAAGTTCCTCTCAGCTGTCCTTGCTGCTCAGAAAGCTCAGTCACAG
CTTCTTGTTCCAGAGCAAAAGGACTCATCTAGCTGGTACCAGAAATTAGACACTAAGGAC
AAACCTTCTGTTTTTTCAGGGCTTCTTGGATTTGAAGACAATTTTTCTTCTATGAATTTG
GACAAGAAAATAAATTCACAAAATCAGCCTACTGGGATTCATCGGGAACCCCCACCTCCA
CCCTTTTCAGTGAATAAAATGCTTCCACGTGAAAAAGAAGCTTCTAACAAGGAGCAGCCC
AAAGTGACCAACACCATGCGGAAGCTCTTTGTACCAAATACCCAATCTGGGCAGCGGGAG
GGTCTCATCAAACATATCCTGGCAAAGCGAGAGAAAGAATATGTCAACATTCAGACTTTC
AGATTTTTTGTTGGAACTTGGAATGTGAATGGCCAGTCTCCAGATAGCGGGTTAGAACCT
TGGCTGAACTGTGATCCCAATCCTCCTGATATCTACTGCATTGGATTCCAAGAACTGGAC
TTGAGCACAGAAGCCTTCTTCTACTTTGAATCTGTGAAGGAACAAGAATGGTCCATGGCT
GTAGAGAGAGGTTTGCATTCCAAAGCCAAGTATAAGAAAGTTCAACTGGTGCGCCTTGTT
GGGATGATGCTTCTTATATTTGCCAGAAAGGATCAGTGTCGATACATTCGTGATATTGCT
ACAGAAACAGTTGGAACTGGAATCATGGGGAAAATGGGAAACAAAGGTGGGGTAGCTGTG
AGATTTGTATTTCACAACACCACCTTTTGCATTGTCAATTCCCATCTGGCTGCACACGTG
GAGGACTTTGAGAGAAGGAATCAAGATTATAAGGACATTTGTGCGAGAATGAGTTTTGTG
GTCCCAAATCAGACCCTCCCGCAGTTGAACATCATGAAACATGAGGTTGTCATTTGGTTG
GGAGATTTGAATTATAGACTTTGCATGCCTGATGCCAATGAGGTGAAAAGTCTTATTAAT
AAGAAAGACCTTCAGAGACTCTTGAAATTCGACCAGCTAAATATTCAGCGCACACAGAAA
AAAGCTTTTGTTGACTTCAATGAAGGGGAAATCAAGTTCATCCCCACTTATAAGTATGAC
TCTAAAACAGACCGGTGGGATTCCAGTGGGAAATGCCGGGTTCCAGCCTGGTGTGACCGA
ATTCTTTGGAGAGGAACAAATGTTAATCAGCTTAATTATCGGAGTCACATGGAACTGAAA
ACCAGCGACCACAAGCCTGTTAGCGCCCTCTTCCATATTGGGGTGAAGGTTGTGGATGAA
CGAAGGTACCGGAAAGTCTTTGAAGATAGTGTACGCATCATGGACAGAATGGAAAATGAC
TTCCTTCCTTCCTTAGAACTCAGCAGGAGGGAGTTTGTGTTTGAAAATGTGAAGTTTCGG
CAACTACAAAAGGAGAAGTTCCAGATCAGCAACAATGGACAGGTTCCCTGCCATTTTTCT
TTCATCCCTAAACTTAATGACAGCCAGTACTGCAAGCCATGGCTTCGGGCTGAACCTTTT
GAGGGCTACTTGGAGCCAAATGAGACAGTGGACATTTCTCTTGATGTGTATGTCAGCAAA
GACTCTGTAACCATCCTGAACTCGGGAGAAGATAAGATTGAAGATATTCTCGTCCTTCAC
CTGGATCGAGGCAAAGATTACTTCTTGACTATCAGTGGAAATTACCTCCCAAGTTGTTTT
GGCACATCCTTAGAGGCTCTGTGCCGTATGAAAAGACCAATCCGAGAAGTTCCTGTTACC
AAACTCATAGACTTGGAGAAATCCCTTCTGCAAATGGTTCCTTTGGATGAAGGTGCCAGT
GAGAGACCCCTTCAGGTTCCCAAGGAGATCTGGCTTCTAGTAGATCACCTATTCAAATAC
GCCTGTCACCAGGAGGACCTGTTCCAGACCCCTGGAATGCAGGAAGAGCTCCAGCAGATC
ATTGATTGTCTGGATACCAGCATTCCTGAGACAATCCCTGGCAGCAACCACTCTGTGGCT
GAAGCACTGCTCATTTTCTTGGAAGCCCTGCCAGAGCCAGTCATCTGTTACGAGCTGTAT
CAGCGATGTCTTGACTCTGCTTATGATCCCCGGATCTGCCGACAGGTGATCTCCCAGCTT
CCGAGATGCCATAGAAATGTTTTCCGTTACTTGATGGCATTCCTTCGAGAACTCTTAAAA
TTCTCTGAATACAATAGCGTCAATGCCAACATGATCGCTACTCTCTTCACTAGTCTTCTC
CTGAGGCCTCCACCCAACCTTATGGCAAGACAGACTCCAAGTGACCGCCAGCGTGCTATT
CAGTTCCTTCTGGGCTTTCTGCTTGGGAGCGAAGAAGACTAA
>OriGene 5' read for NM_001587 unedited
CATTATGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGCGCAGCCGAGGT
GGGTGGGTGTGGGGACGCGGGAGCCAGTGTCGTCGGATCGGCCCGCAGTCCGCTGTCCTG
CTGAGCCCGGAGGCCGCCTGGATGGAGCCGCCGCTCCCGGTCGGAGCCCAGCCGCTTGCC
ACTGTCGAGGGTATGGAGATGAAGGGTCCTCTCCGGGAGCCCTGCGCCCTGACCCTAGCC
CAGAGGAACGGGCAATATGAGTTAATAATCCAGTTGCATGAGAAGGAACAGCATGTTCAA
GATATCATTCCTATAAATAGCCACTTCAGATGTGTTCAAGAAGCAGAAGAAACTCTTTTG
ATTGACATAGCTTCTAACAGTGGCTGCAAAATTCGGGTTCAGGGGGACTGGATCAGAGAG
CGCCGCTTTGAAATCCCTGATGAGGAACACTGTTTGAAGTTCCTCTCAGCTGTCCTTGCT
GCTCAGAAAGCTCAGTCACAGCTTCTTGTTCCAGAGCAAAAGGACTCATCTAGCTGGTAC
CAGAAATTAGACACTAAGGACAAACCTTCTGTTTTTTCAGGGCTTCTTGGATTTGAAGAC
AATTTTTCTTCTATGAATTTGGACAAGAAAATAAATTCACAAAATCAGCCTACTGGGATT
CATCGGGAACCCCCACCTCCACCCTTTTCAGTGAATAAAATGCTTCCACGTGAAAAAGAA
GCTTCTAACAAGGAGCAGCCCAAAGTGACCAACACCATGCGGAAGCTCTTTGTACCAAAT
ACCCAATCTGGGCAGCGGGAGGGTCTCATCAAACATATCCTGGCANAGCGAGAGAAAGAA
TATGTCAACATTCAGAACTTCAGATTTTNTGTTGGAACTTGGNATGTGAATGCCCAGTCT
CCAGATAGCGGGNTAGAACCTTGCNCTGACTGTGATCCCCATCCTNCTGATATCTACTGC
ATNGGATTCCAGAACTGGNACTGAGCACAAAGN
>OriGene 3' read for NM_001587 unedited
TTCNTTGNACCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTTTAACAC
AACATATATTTATTCAGAAAAAATTTGCAATAAATTATAATAAAAAAGAGACACGAAATA
TAGAATCCCACTAGCAGCTTTGCTTAGTGATCAAGACGTTTTTGGGAAATATAACAAACA
ATTACAGAATAAGAAAACAGTGAAAGGGAGACTAATGCAATGTCACCACATGGATTTGAA
CCATTTCTTCCCTAAGACAGCAGGTGCAGAGTCTTTCCCTACCAGCTGAATCCGAAATCC
TTACTTCAGAGCAGCTACAAATTAGTACCTTAAAGGACTTGGCAATTACAGGTTGGGGTG
CTGGAATAGCCATGGTAGGGAAGCAGATTTCTTCTGTCTGGGTCTACATCTTGTCTCCTC
TACCTAGAGATTGTCTAAAACTCTCAACTCTGTATATGTTCCAGGATGAGCTGAAAAAAG
GTCGAGGCAGTACACCAACTTAGTGTTTTGATCTGATGTACAAAGAGATAGGATACTGCA
TACGTGCAGCACAGAGCCTCCACTAACCACACCCTTGATCACCCAAAGATCCCAGGTCAG
CGATATGCTAGAAAACAAGCCCAGGAAAGGTATTTTCCTGTGGAATGACCCTACCCAGTG
CCTATCATCTGCCTCTTTTTGAGATCACTTTTTGGCCCTGCGGAGATGAACAACTGCTCT
TGCCTAAGTCTTCCATTAACTAAGTCCAACACTACCCCCCGACTTATATACCTGCAAATC
TGGGCCCACTCCTGGACTTTAAGCTTTACTTCTAAGAGCACGGGTGATCCCTCTGCCACA
TACCCCCTTGCCCCCCCCTCCCGATCACATTGACTTCCCTGGTGCCCCTCCCCTCCTCAA
TGCCCACACGGTCCCCCGATTACTTACGTCCC
Restriction Sites NotI-NotI     
ACCN NM_001587
Insert Size 5120 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001587.3, NP_001578.2
RefSeq Size 5141 bp
RefSeq ORF 2682 bp
Locus ID 4952
Cytogenetics Xq26.1
Domains RhoGAP, IPPc, Exo_endo_phos
Protein Families Druggable Genome
Protein Pathways Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system
Gene Summary 'This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]'
Transcript Variant: This variant (b) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) that has a shorter C-terminus, compared to isoform 1.

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