Angiopoietin 2 (ANGPT2) (NM_001147) Human Untagged Clone

CAT#: SC119420

ANGPT2 (untagged)-Human angiopoietin 2 (ANGPT2), transcript variant 1


  "NM_001147" in other vectors (6)

Reconstitution Protocol

USD 760.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol ANGPT2
Synonyms AGPT2; ANG2
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC119420 sequence for NM_001147 edited (data generated by NextGen Sequencing)
ATGTGGCAGATTGTTTTCTTTACTCTGAGCTGTGATCTTGTCTTGGCCGCAGCCTATAAC
AACTTTCGGAAGAGCATGGACAGCATAGGAAAGAAGCAATATCAGGTCCAGCATGGGTCC
TGCAGCTACACTTTCCTCCTGCCAGAGATGGACAACTGCCGCTCTTCCTCCAGCCCCTAC
GTGTCCAATGCTGTGCAGAGGGACGCGCCGCTCGAATACGATGACTCGGTGCAGAGGCTG
CAAGTGCTGGAGAACATCATGGAAAACAACACTCAGTGGCTAATGAAGCTTGAGAATTAT
ATCCAGGACAACATGAAGAAAGAAATGGTAGAGATACAGCAGAATGCAGTACAGAACCAG
ACGGCTGTGATGATAGAAATAGGGACAAACCTGTTGAACCAAACAGCTGAGCAAACGCGG
AAGTTAACTGATGTGGAAGCCCAAGTATTAAATCAGACCACGAGACTTGAACTTCAGCTC
TTGGAACACTCCCTCTCGACAAACAAATTGGAAAAACAGATTTTGGACCAGACCAGTGAA
ATAAACAAATTGCAAGATAAGAACAGTTTCCTAGAAAAGAAGGTGCTAGCTATGGAAGAC
AAGCACATCATCCAACTACAGTCAATAAAAGAAGAGAAAGATCAGCTACAGGTGTTAGTA
TCCAAGCAAAATTCCATCATTGAAGAACTAGAAAAAAAAATAGTGACTGCCACGGTGAAT
AATTCAGTTCTTCAAAAGCAGCAACATGATCTCATGGAGACAGTTAATAACTTACTGACT
ATGATGTCCACATCAAACTCAGCTAAGGACCCCACTGTTGCTAAAGAAGAACAAATCAGC
TTCAGAGACTGTGCTGAAGTATTCAAATCAGGACACACCACAAATGGCATCTACACGTTA
ACATTCCCTAATTCTACAGAAGAGATCAAGGTCTACTGTGACATGGAAGCTGGAGGAGGC
GGGTGGACAATTATTCAGCGACGTGAGGATGGCAGCGTTGATTTTCAGAGGACTTGGAAA
GAATATAAAGTGGGATTTGGTAACCCTTCAGGAGAATATTGGCTGGGAAATGAGTTTGTT
TCGCAACTGACTAATCAGCAACGCTATGTGCTTAAAATACACCTTAAAGACTGGGAAGGG
AATGAGGCTTACTCATTGTATGAACATTTCTATCTCTCAAGTGAAGAACTCAATTATAGG
ATTCACCTTAAAGGACTTACAGGGACAGCCGGCAAAATAAGCAGCATCAGCCAACCAGGA
AATGATTTTAGCACAAAGGATGGAGACAACGACAAATGTATTTGCAAATGTTCACAAATG
CTAACAGGAGGCTGGTGGTTTGATGCATGTGGTCCTTCCAACTTGAACGGAATGTACTAT
CCACAGAGGCAGAACACAAATAAGTTCAACGGCATTAAATGGTACTACTGGAAAGGCTCA
GGCTATTCGCTCAAGGCCACAACCATGATGATCCGACCAGCAGATTTCTAA

Clone variation with respect to NM_001147.2
408 g=>t;735 g=>a;882 g=>a;932 c=>t
>OriGene 5' read for NM_001147 unedited
AAAGTCAGAATTGTATACGACTCATATAGGCGGCCGCGCAATTCGCACGAGGCCTCGTGC
CGAATTCNGCACGAGGCATGGGGCCTGGGTGGGGGGCAGGCATTCTGCTCTGATTTTTCC
TGTGGCCTGGCTAGTGACCCCCTACAGGGAAGATAACGGCTAAGCCAGGAGGGCGGAGCA
GCCCACTACACATGTCTGGCTGCTCTTATCAACTTATCATATAANGAAAGGAAAGTGATT
GAGTCGGATACTGACACTGTAGGATCTGGGGAGAGAGGAACAAAGGACCGTGAAAGCTGC
TCTGTAAAAGCTGACACAGCCCTCCCAAGTGAGCAGGAGTGGTCTTCCCACTGGAATCTG
ACAGTTTACTGCATGCCTGGAGAGAACACAGCAGTAAAAACCAGGTTTGCTACTGGAAAA
AGAGGAAAGAGAAGACTTTCATTGGCGGACCCAGCCATGGCAGCGTAGCAGCCCTGCGTT
TCAGACGGCAGCAGCTCGGGACTCTGGACGTGTGTTTGCCCTCAAGTTTGCTAAGCTGCT
GGTTTATTACTGAAGAAAGAATGTGGCAGATTGGTTTCTTTACTCTGAGCTGTGATCTTG
GCTTGGCCGCAGCCTATAACAACTTTCGGAAGAGCATGGACAGCATANGAAAGAAGCAAT
ATCAGGTGCAGCATGGGTCCTGCAGCTACACTTTCCTCCTGCGAGAGATGGACAACTGCC
GCTCTTCCTCCAGCCCCTACGTGTCCAATGCTGTGCANAGGGACCCGCCGCTCNAATACA
ATGACTCCGTGCANAGGCTGCAAGTGCTGGAGAACATCATGGGAAACACACTCAGTGGCT
AATGAAGCTTGAGAATATATCCGGGACACATGAAGAAAGAATGGTGGAATACAGCAGATG
CGGTCAA
>OriGene 3' read for NM_001147 unedited
GCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTATCCCCTAATAAGTTATATTTAA
TTACTAAAAATACCTTCATATTTAACAATCAGGCAGAAAAAAATAGTACGGTCTGCATAT
AAACTAAAATGGCACGTTTCTGTTGATAATTTCAGAGATTCTGGAAGTTTCTACCATATA
AATTTGAAATACGTATTTGAGCATTAACTTATAACTAAGCTGTCAACATAAATGTAAATA
CGCTGTTTTTGAAATAAAAATTTAAAGCACCTAAGAGATGGAGTAAAAATGCACTAACTG
TTTTTCCAAATATTAAACTTCTAGTAACCCCTTCTCAGAATATCCCTGAATATGTCTTTT
TATGGCTTAGAGAGTTTTTTTCTTCCTTTTAATTGTGATAGTGATGGTGAATTCAGGACA
TATGGGTATTTACACAGTGTATAAACAGTGCTCAGAAGAATGCAGTTCCAAGATGATCTG
TATTGTATAACATAAGTGTTCTGTTTTCCAGTTATTTACTGATAAACTTGCACATAACAT
TCTTGGTTGTGACAGCAGCGTCTGTAAACTGTCAGTCTGATTCTCAGCCTCGGGTTCATC
TTTGCATAGGTGTTCTGTCTAATCACAATTATGGATGTTTAGGGTCTTGCTTTGGTCCGT
TAAGTGATGCAAGTTTAAGTGATAAAGTTTACAGGCTCTAATCTGGAGCATGTGGGTCCC
GTCAGCACCGAGCACACGCCCTCTGTGGGTGGAAGAGACACAGTGCGCAGCCGTGACTTT
CAGTGCACTGGGCTTAAGTCTTTGAAATAGTTCGAGACAGTCCTTCAGTGACCTGGATGT
TTAGAATCTGCTGGTCGGACATCATGGNTGTGGCCTTGAGCGATAGCCTGACCCTTTCAG
TATACCATNTAATGCCGNTGACTTATTTGGGGTCTGGCCCTGGGGAAAGNACATTCCGCT
CAAGNTGGAGGGACACATGCATCAACCACCACCTNCT
Restriction Sites NotI-NotI     
ACCN NM_001147
Insert Size 2770 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001147.1, NP_001138.1
RefSeq Size 2269 bp
RefSeq ORF 1491 bp
Locus ID 285
Cytogenetics 8p23.1
Domains FBG
Protein Families Druggable Genome, Secreted Protein
Gene Summary 'This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020]'
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

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