UGT1A6 (NM_001072) Human Untagged Clone

CAT#: SC119463

UGT1A6 (untagged)-Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: UGT1A6
• Synonyms: GNT1; HLUGP; HLUGP1; hUG-BR1; UDPGT; UDPGT 1-6; UGT-1A; UGT-1C; UGT-1E; UGT1; UGT1-01; UGT1-03; UGT1-05; UGT1.1; UGT1.3; UGT1.5; UGT1A; UGT1A1; UGT1A3; UGT1A5; UGT1A6S; UGT1C; UGT1E; UGT1F
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC119463 sequence for NM_001072 edited (data generated by NextGen Sequencing)
  ATGGCCTGCCTCCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTT
  TGGGGCATGGTTGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTT
  AGTATGAAGGATATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTG
  CCTGAAGTTAATTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTG
  CCGTATGACCAAGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCT
  GAGCGATCATTCCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGC
  CTGTACTTCATCAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAG
  GAGAGCAAGTTTGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCT
  GAGTATTTGGGCCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCAT
  ACATTCAGCAGAAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCA
  GACCACATGACTTTTTCCCAACGAGTGGCCAACTTCCTTGTTAATTTGTTGGAGCCCTAT
  CTATTTTATTGTCTGTTTTCAAAGTATGAAGAACTCGCATCAGCTGTCCTCAAGAGAGAT
  GTGGATATAATCACCTTATATCAGAAGGTCTCTGTTTGGCTGTTAAGATATGACTTTGTG
  CTTGAATATCCTAGGCCGGTCATGCCCAACATGGTCTTCATTGGAGGTATCAACTGTAAG
  AAGAGGAAAGACTTGTCTCAGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGA
  ATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCA
  ATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGA
  CCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTT
  GGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGC
  ATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCA
  AAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAA
  GATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATG
  CGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGG
  GTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTC
  ACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACA
  GTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAA
  GGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA
  
  Clone variation with respect to NM_001072.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001072 unedited
  GGCCCCCGGGCCCNNNNNNNCCNCCTCCCCCCCCTGTTCAAATTTGTNATACGACTCATA
  TAGGCGGCCGCGNAATTCGCACGAGGTTAGTTTAGGGAAAATACCTAGAGCCCTGTGATT
  TGGAGAGTGAAAACTCTTTATTACCGTTGTTACTTTAACTCTTTCCAGGATGGCCTGCCT
  CCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTTTGGGGCATGGT
  TGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTTAGTATGAAGGA
  TATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTGCCTGAAGTTAA
  TTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTGCCGTATGACCA
  AGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCTGAGCGATCATT
  CCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGCCTGTACTTCAT
  CAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAGGAGAGCAAGTT
  TGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCTGAGTATTTGGG
  CCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCATACATTCAGCAG
  AAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCAGACCACATGAC
  TTTNTCCCAACGAGTGGCCAACTTCCTTGNTAATTTGTTGGAGCCCTATCTATTNTATTG
  NCTGTTTTCAAATATGAAAAACTCGCATCAGCTGTCCTCAGAAGAGATGTGGATATAATC
  ACCTATATCAGAA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001072 unedited
  TCACTCTGGACCCGCGGCCGCAANCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTTTATAAAAATTAATTAATTTATTTTTAGTGGGAGGAAACATCAAAAAAA
  AATAAACTTGCCCAGCACTTCATAGCTGTATTTGGGGTTTTTATCAAATTCAGCTCCATT
  TGACATAAGCAATGATTATTTTCTCAAATACCCCACCCACCAATTTCATAGCATCATTTT
  TTTTCCCCAAAGCAAAAAATCATATGCTGTTCTCAGGGCACTCCAAGCCATTCATTCATT
  TCACCTACACTTTAAAGGGACAAAGCTTCCCTTTTTTAAACACACAAGGGGGCCCCTATG
  AAGCCCGACAGAGATGAGGACTGACCATTATTGGTTAAGGATCAATTGCAACCATCTGCA
  GAAGCCAAAAGATAAAATTAAAACTGCCATTTGCAGTAGGGGCAGCCGGGGGACCACCTT
  TGAATCCCGCACTCCCAAACAGGCCATGTTTCAAAGTAAAAAAAGTAATCTAAAATGCCA
  GCCTGTCTGCACGTCCTTTGAAAAATGGCACATGTCATCCTGATCAAAGACACCAGAGGG
  GGCACGATACATATTCAAATATCTTTACTGACTAGCGAGTCTATTATTTTTATTTAAAAG
  AATTTTTTAAAGCACTCTGGGGGCTGATATAATTATGCAAAGTATTTCCTTAATAAGATA
  AAATGAATTTACACTGATTCTGTTTTTCAGTTTGGAAAGACTAGGGAATGGTTCAAATTT
  TACCTTATTTCCACCCACTCTCATGGGTCTGGNATTTGGGGGCTTTCTTACTCGCCCTTT
  TTCCCAGCATTTTCGGTAGCTAGCACACATTTAAGTGATGAAGGCCCTGTANCACGACGC
  CAGAGAACCAATACGTCAGGATGTACTGTACAATGAGGTCCTGGCTGCGGCCCAAGGTGC
  GCCCCT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001072
• ORF Size: 1599 bp
• Insert Size: 2560
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_001072.2, NP_001063.2
• RefSeq Size: 2435
• RefSeq ORF: 1599
• Locus ID: 54578
• Domains: UDPGT
• Protein Families: Transmembrane
• Protein Pathways: Androgen and estrogen metabolism, Ascorbate and aldarate metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Retinol metabolism, Starch and sucrose metabolism
• Gene Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the longer transcript. Its first exon contains both the 5' UTR and the 5' coding sequence, as is typical of the UGT1A genes.