UGT2B7 (NM_001074) Human Untagged Clone

CAT#: SC119466

UGT2B7 (untagged)-Human UDP glucuronosyltransferase 2 family, polypeptide B7 (UGT2B7)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: UGT2B7
• Synonyms: UDPGT 2B7; UDPGT2B7; UDPGT 2B9; UDPGTh-2; UDPGTH2; UGT2B9
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC119466 sequence for NM_001074 edited (data generated by NextGen Sequencing)
  ATGTCTGTGAAATGGACTTCAGTAATTTTGCTAATACAACTGAGCTTTTGCTTTAGCTCT
  GGGAATTGTGGAAAGGTGCTGGTGTGGGCAGCAGAATACAGCCATTGGATGAATATAAAG
  ACAATCCTGGATGAGCTTATTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
  TCCATTCTTTTTGATCCCAACAACTCATCCGCTCTTAAAATTGAAATTTATCCCACATCT
  TTAACTAAAACTGAGTTGGAGAATTTCATCATGCAACAGATTAAGAGATGGTCAGACCTT
  CCAAAAGATACATTTTGGTTATATTTTTCACAAGTACAGGAAATCATGTCAATATTTGGT
  GACATAACTAGAAAGTTCTGTAAAGATGTAGTTTCAAATAAGAAATTTATGAAAAAAGTA
  CAAGAGTCAAGATTTGACGTCATTTTTGCAGATGCTATTTTTCCCTGTAGTGAGCTGCTG
  GCTGAGCTATTTAACATACCCTTTGTGTACAGTCTCAGCTTCTCTCCTGGCTACACTTTT
  GAAAAGCATAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAGAA
  TTAACTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTACTTT
  GACTTTTGGTTCGAAATATTTGACATGAAGAAGTGGGATCAGTTTTATAGTGAAGTTCTA
  GGAAGACCCACTACATTATCTGAGACAATGGGGAAAGCTGACGTATGGCTTATTCGAAAC
  TCCTGGAATTTTCAGTTTCCATATCCACTCTTACCAAATGTTGATTTTGTTGGAGGACTC
  CACTGCAAACCTGCCAAACCCCTGCCTAAGGAAATGGAAGACTTTGTACAGAGCTCTGGA
  GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGG
  GCCAACGTAATTGCATCAGCCCTGGCCCAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
  GGGAATAAACCAGATACCTTAGGTCTCAATACTCGGCTCTACAAGTGGATACCCCAGAAT
  GACCTTCTAGGTCATCCAAAGACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
  TACGAGGCAATCTACCATGGGATCCCTATGGTGGGGATTCCATTGTTTGCCGATCAACCT
  GATAACATTGCTCACATGAAGGCCAGGGGAGCAGCTGTTAGAGTGGACTTCAACACAATG
  TCGAGTACAGACTTGCTGAATGCATTGAAGAGAGTAATTAATGATCCTTCATATAAAGAG
  AATGTTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCA
  GTCTTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCTAAACACCTTCGGGTTGCAGCC
  CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGTCTGT
  GTGGCAACTGTGATATTTATCGTCACAAAATGTTGTCTGTTTTGTTTCTGGAAGTTTGCT
  AGAAAAGCAAAGAAGGGAAAAAATGATTAG
  
  Clone variation with respect to NM_001074.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001074 unedited
  GTCACAATTGTATACGACTCATATAGGCGGCNCGCGAATTCGCACCAGGNAAAACAAGCA
  TTGCATTGCACCAGGATGTCTGTGAAATGGACTTCAGTAATTTTGCTAATACAACTGAGC
  TTTTGCTTTAGCTCTGGGAATTGTGGAAAGGTGCTGGTGTGGGCAGCAGAATACAGCCAT
  TGGATGAATATAAAGACAATCCTGGATGAGCTTATTCAGAGAGGTCATGAGGTGACTGTA
  CTGGCATCTTCAGCTTCCATTCTTTTTGATCCCAACAACTCATCCGCTCTTAAAATTGAA
  ATTTATCCCACATCTTTAACTAAAACTGAGTTGGAGAATTTCATCATGCAACAGATTAAG
  AGATGGTCAGACCTTCCAAAAGATACATTTTGGTTATATTTTTCACAAGTACAGGAAATC
  ATGTCAATATTTGGTGACATAACTAGAAAGTTCTGTAAAGATGTAGTTTCAAATAAGAAA
  TTTATGAAAAAAGTACAAGAGTCAAGATTTGACGTCATTTTTGCAGATGCTATTTTTCCC
  TGTAGTGAGCTGCTGGCTGAGCTATTTAACATACCCTTTGTGTACAGTCTCAGCTTCTCT
  CCTGGCTACACTTTTGAAAAGCATAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCT
  GTTGTTATGTCAGAATTAACTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATC
  TATGTGCTTTACTTTGACTTTTGGTTCGAAATATTTGNACATGAAGAGTGGGATCAGTTT
  TATAGTGAAGTTCTAGGAAGACCCACTACATTATCTGAGACAATGGGGAAAGCTGACGTA
  TGGCTTATTCGAAACTCCTGGAATTTTCAGTTTCCATATCCACTCTTACCAATGTTGATT
  TTGTTGGNAGACTCCACTGCAACCTGNCAAACCCTGCCTAAGAAA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001074 unedited
  TTTCTCGCTGGCATAAACTGAAGTATCGACCTAAAGGTTTTCCAGCTTCAAATATCAGGT
  ATAACTAATCATTTTTATCCTTCTTTGCTTTTGTAGCAAACTTCCAGAAACAAAACAGAC
  AACATTTTGTGACGATAAATATCACAGTTGCCACACAGACCAGCAGGAACCCAATCACAT
  CCAAAGAGTGGTACTGGAACCAGGTGAGGTCGTGGGCTGCAACCCGAAGGTGTTTAGCTC
  CTTTGTGGCGCATGACAAATTCAATCCAGAAGACTGCTCGATCCAGGGGCTTCACTGGTT
  GATATATGTTGAATTCTTGATAATTTCATAACATTCTCTTTATATGAAGGATCATTAATT
  ACTCTCTTCAATGCATTCAGCAAGTCTGTACTCGACATTGCGTTGAAGTCCACTCTAACA
  GCTGCTCCCCTGGCCTTCATGTGAGCAAATGTTATCAGGTTGATCGGCAAACAATGGAAT
  CCCCACCCATAGGGATCCCATGGTAGATTGCCTCGTAGATGCCATGGGCTCCACCATGAA
  GTATAAAGCTCTGGGCTTTGGATGACCCTAGAAGGACATTCTGGGGTATCCACTTTGTAA
  AGCCAAGTTTGAGACCTAAGGTATTTGGTTTATTCCCCATCAAAACTTCCCGGAACTCTT
  TGTGGGAACTGGGCCAGGGCTTGATGCAATTACCTAGGGCCTTTTATTCTGGCCAGTTAC
  TGAACACTCCCCCCCAGAGAAAAACCCCCACCACCCTCTTTACGAGAGAGTTGGGGCAAA
  GGGTTTCTCATTCCTTAAGGAACGGTGTTTGCAAGGTTTGAATGGTAGACCCCCCACGGA
  ATTAATTTTGGCAAAGGGGTATTGCGAAACTGAAAATCGAGAGTTCGAAATACCCATAGT
  CGGGTTTGCCCGTTGGTACAAAAAGTGGGGGGG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001074
• Insert Size: 1750 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001074.1, NP_001065.1
• RefSeq Size: 1855 bp
• RefSeq ORF: 1590 bp
• Locus ID: 7364
• Cytogenetics: 4q13.2
• Domains: UDPGT
• Protein Families: Transmembrane
• Protein Pathways: Androgen and estrogen metabolism, Ascorbate and aldarate metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Retinol metabolism, Starch and sucrose metabolism
• Gene Summary: 'The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]'
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).