epithelial Sodium Channel alpha (SCNN1A) (NM_001038) Human Untagged Clone

CAT#: SC119542

SCNN1A (untagged)-Human sodium channel, nonvoltage-gated 1 alpha (SCNN1A), transcript variant 1


  "NM_001038" in other vectors (7)

Reconstitution Protocol

USD 310.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol SCNN1A
Synonyms BESC2; ENaCa; ENaCalpha; LIDLS3; SCNEA; SCNN1
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC119542 sequence for NM_001038 edited (data generated by NextGen Sequencing)
ATGGAGGGGAACAAGCTGGAGGAGCAGGACTCTAGCCCTCCACAGTCCACTCCAGGGCTC
ATGAAGGGGAACAAGCGTGAGGAGCAGGGGCTGGGCCCCGAACCTGCGGCGCCCCAGCAG
CCCACGGCGGAGGAGGAGGCCCTGATCGAGTTCCACCGCTCCTACCGAGAGCTCTTCGAG
TTCTTCTGCAACAACACCACCATCCACGGCGCCATCCGCCTGGTGTGCTCCCAGCACAAC
CGCATGAAGACGGCCTTCTGGGCAGTGCTGTGGCTCTGCACCTTTGGCATGATGTACTGG
CAATTCGGCCTGCTTTTCGGAGAGTACTTCAGCTACCCCGTCAGCCTCAACATCAACCTC
AACTCGGACAAGCTCGTCTTCCCCGCAGTGACCATCTGCACCCTCAATCCCTACAGGTAC
CCGGAAATTAAAGAGGAGCTGGAGGAGCTGGACCGCATCACAGAGCAGACGCTCTTTGAC
CTGTACAAATACAGCTCCTTCACCACTCTCGTGGCCGGCTCCCGCAGCCGTCGCGACCTG
CGGGGGACTCTGCCGCACCCCTTGCAGCGCCTGAGGGTCCCGCCCCCGCCTCACGGGGCC
CGTCGAGCCCGTAGCGTGGCCTCCAGCTTGCGGGACAACAACCCCCAGGTGGACTGGAAG
GACTGGAAGATCGGCTTCCAGCTGTGCAACCAGAACAAATCGGACTGCTTCTACCAGACA
TACTCATCAGGGGTGGATGCGGTGAGGGAGTGGTACCGCTTCCACTACATCAACATCCTG
TCGAGGCTGCCAGAGACTCTGCCATCCCTGGAGGAGGACACGCTGGGCAACTTCATCTTC
GCCTGCCGCTTCAACCAGGTCTCCTGCAACCAGGCGAATTACTCTCACTTCCACCACCCG
ATGTATGGAAACTGCTATACTTTCAATGACAAGAACAACTCCAACCTCTGGATGTCTTCC
ATGCCTGGAATCAACAACGGTCTGTCCCTGATGCTGCGCGCAGAGCAGAATGACTTCATT
CCCCTGCTGTCCACAGTGACTGGGGCCCGGGTAATGGTGCACGGGCAGGATGAACCTGCC
TTTATGGATGATGGTGGCTTTAACTTGCGGCCTGGCGTGGAGACCTCCATCAGCATGAGG
AAGGAAACCCTGGACAGACTTGGGGGCGATTATGGCGACTGCACCAAGAATGGCAGTGAT
GTTCCTGTTGAGAACCTTTACCCTTCAAAGTACACACAGCAGGTGTGTATTCACTCCTGC
TTCCAGGAGAGCATGATCAAGGAGTGTGGCTGTGCCTACATCTTCTATCCGCGGCCCCAG
AACGTGGAGTACTGTGACTACAGAAAGCACAGTTCCTGGGGGTACTGCTACTATAAGCTC
CAGGTTGACTTCTCCTCAGACCACCTGGGCTGTTTCACCAAGTGCCGGAAGCCATGCAGC
GTGACCAGCTACCAGCTCTCTGCTGGTTACTCACGATGGCCCTCGGTGACATCCCAGGAA
TGGGTCTTCCAGATGCTATCGCGACAGAACAATTACACCGTCAACAACAAGAGAAATGGA
GTGGCCAAAGTCAACATCTTCTTCAAGGAGCTGAACTACAAAACCAATTCTGAGTCTCCC
TCTGTCACGATGGTCACCCTCCTGTCCAACCTGGGCAGCCAGTGGAGCCTGTGGTTCGGC
TCCTCGGTGTTGTCTGTGGTGGAGATGGCTGAGCTCGTCTTTGACCTGCTGGTCATCATG
TTCCTCATGCTGCTCCGAAGGTTCCGAAGCCGATACTGGTCTCCAGGCCGAGGGGGCAGG
GGTGCTCAGGAGGTAGCCTCCACCCTGGCATCCTCCCCTCCTTCCCACTTCTGCCCCCAC
CCCATGTCTCTGTCCTTGTCCCAGCCAGGCCCTGCTCCCTCTCCAGCCTTGACAGCCCCT
CCCCCTGCCTATGCCACCCTGGGCCCCCGCCCATCTCCAGGGGGCTCTGCAGGGGCCAGT
TCCTCCGCCTGTCCTCTGGGGGGGCCCTGA

Clone variation with respect to NM_001038.5
1987 a=>g
>OriGene 5' read for NM_001038 unedited
NTGTCAGNATTTGTATACGACTCCTATAGGCGGCCCGCGAATCGGCACCAGGGGACATGG
GCATGGCCAGGGGCAGCCTCACTCGGGTTCCAGGGGTGATGGGAGAGGGCACTCAGGGCC
CAGAGCTCAGCCTTGACCCTGACCCTTGCTCTCCCCAATCCACTCCGGGGCTCATGAAGG
GGAACAAGCTGGAGGAGCAGGACCCTAGACCTCTGCAGCCCATACCAGGTCTCATGGAGG
GGAACAAGCTGGAGGAGCAGGACTCTAGCCCTCCACAGTCCACTCCAGGGCTCATGAAGG
GGAACAAGCGTGAGGAGCAGGGGCTGGGCCCCGAACCTGCGGCGCCCCAGCAGCCCACGG
CGGAGGAGGAGGCCCTGATCGAGTTCCACCGCTCCTACCGAGAGCTCTTCGAGTTCTTCT
GCAACAACACCACCATCCACGGCGCCATCCGCCTGGTGTGCTCCCAGCACAACCGCATGA
AGACGGCCTTCTGGGCAGTGCTGTGGCTCTGCACCTTTGGCATGATGTACTGGCAATTCG
GCCTGCTTTTCGGAGAGTACTTCAGCTACCCCGTCAGCCTCAACATCACCCTCAACTCGG
ACAAGCTCGTCTTCCCCGCAGTGACCATCTGCACCCTCAATCCCTACAGGTACCCGGAAA
TTAAAGAGGAGCTGGAGGAGCTGGACCGCATCACAGAGCAGACGCTCTTTGACCTGTACA
ATACAGCTCCTTCACCACTCTCGTGGCCGGCTCCCGCAGCCGTCGCGACCTGCGGNGGAC
TCTGCCGCACCCCTTGCAGCGCCCTGAGGTCCCGCCCCCGCCTCACGGNGCCCGTCGAGC
CCGTAACGTGGCCTCCAGCTTGCGGGGACACAACCCCCAGNTNACTGGAAGGACTGGNAG
ATCCGCTCCAGCTGTGCAACCAGACAAATCGACTGCTCTACCAA
>OriGene 3' read for NM_001038 unedited
CTATGAACCCGCGGCCGCAATCTAGNGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTCACAGCCAACAAACTTTTATGGAACCTCCTGCCTACTTGCTCCAAGCAGGA
AGAGGGGCTAAACATGGACCATCCTTAACCGGCCAAAATTCATCCCCTGACCGAAGGGCC
CTAACAGTTTATTGGGAAAGGGAAACCCAATGGTCCAAAAAAGTTTGGGGCAACACCACC
CCTCCACCAAATGTTATAGGGGCCTACGGAACCCCAGAAAAAGGCGGAGGGACCAATTTG
GGGAAAAACAAAATGGGGCAAAACCGTCCACAAAAGAAAGGGGGCCTGACCAGGGTTCTA
AGGAATCCATAGGATTCCTTGGGCAAAGGGTGGGGAAAACTTTAAGCCTGAGGAAATTCC
TAACCCAAACTTGTAAAGGTATAAAAAACCCAGGGCAAAGGGGCCGGGGCATGGTTTTGT
AAGGGCCCGGGTATAAGGCTAAAGGACCCCTGGTCCTGCTTTTACTTACCCGGGCCTGTT
CAAGCCTAATCCCTCGGGACCCAGGAAAGGGAATTTCCCCACCAACAATGGGCCCTTTGG
GCTCGGCTCCCCCCACATCTTCACCCCCAGCCCAACTTTCCTTCTCCCCCTCCCCTCCAC
ACCCTCACTATTCGCATCGTTCCCTCTCCCCCGCCCCTATCTCCTCCCCCCCATACCCCC
CCTTCCCCCTCTCTTTTCCCCTCTTTTTTTATCCTCACGCTTCCCTCCCCCCCCCATTTT
TCTCCTACCCCCCCCCCCCCCCTATTCCCCTCTCCTCTTCCCTTTCCTTAATCCCCGCTC
CCCCCCCATTCTCCCCCCCCTCCCCATCTATGTCAACCTCCACACCCCCCTCCCCCCTCC
CCCCTTCTTCCCCCTCCCCTCCACCTTCCCCACATCAAATCA
Restriction Sites ECoRI-NOT     
ACCN NM_001038
Insert Size 3080 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001038.4, NP_001029.1
RefSeq Size 3171 bp
RefSeq ORF 2010 bp
Locus ID 6337
Cytogenetics 12p13.31
Domains ASC
Protein Families Druggable Genome, Ion Channels: Other, Transmembrane
Protein Pathways Taste transduction
Gene Summary 'Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]'
Transcript Variant: This variant (1, also known as alpha-ENaC1) represents the predominant transcript, and encodes isoform 1.

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