Integrin alpha 4 (ITGA4) (NM_000885) Human Untagged Clone

CAT#: SC119587

ITGA4 (untagged)-Human integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (ITGA4)


  "NM_000885" in other vectors (6)

Reconstitution Protocol

USD 2,100.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol ITGA4
Synonyms CD49D; IA4
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_000885 edited
GAATTCGGCACGAGGCCTTCCTTTAGCCCGCTGGCGCCGGACACGCTGCGCCTCATCTCT
TGGGGCGTTCTTCCCCGTTGGCCAACCGTCGCATCCCGTGCAACTTTGGGGTAGTGGCCG
TTTAGTGTTGAATGTTCCCCACCGAGAGCGCATGGCTTGGGAAGCGAGGCGCGAACCCGG
CCCCCGAAGGGCCGCCGTCCGGGAGACGGTGATGCTGTTGCTGTGCCTGGGGGTCCCGAC
CGGCCGCCCCTACAACGTGGACACTGAGAGCGCGCTGCTTTACCAGGGCCCCCACAACAC
GCTGTTCGGCTACTCGGTCGTGCTGCACAGCCACGGGGCGAACCGATGGCTCCTAGTGGG
TGCGCCCACTGCCAACTGGCTCGCCAACGCTTCAGTGATCAATCCCGGGGCGATTTACAG
ATGCAGGATCGGAAAGAATCCCGGCCAGACGTGCGAACAGCTCCAGCTGGGTAGCCCTAA
TGGAGAACCTTGTGGAAAGACTTGTTTGGAAGAGAGAGACAATCAGTGGTTGGGGGTCAC
ACTTTCCAGACAGCCAGGAGAAAATGGATCCATCGTGACTTGTGGGCATAGATGGAAAAA
TATATTTTACATAAAGAATGAAAATAAGCTCCCCACTGGTGGTTGCTATGGAGTGCCCCC
TGATTTACGAACAGAACTGAGTAAAAGAATAGCTCCGTGTTATCAAGATTATGTGAAAAA
ATTTGGAGAAAATTTTGCATCATGTCAAGCTGGAATATCCAGTTTTTACACAAAGGATTT
AATTGTGATGGGGGCCCCAGGATCATCTTACTGGACTGGCTCTCTTTTTGTCTACAATAT
AACTACAAATAAATACAAGGCTTTTTTAGACAAACAAAATCAAGTAAAATTTGGAAGTTA
TTTAGGATATTCAGTCGGAGCTGGTCATTTTCGGAGCCAGCATACTACCGAAGTAGTCGG
AGGAGCTCCTCAACATGAGCAGATTGGTAAGGCATATATATTCAGCATTGATGAAAAAGA
ACTAAATATCTTACATGAAATGAAAGGTAAAAAGCTTGGATCGTACTTTGGAGCTTCTGT
CTGTGCTGTGGACCTCAATGCAGATGGCTTCTCAGATCTGCTCGTGGGAGCACCCATGCA
GAGCACCATCAGAGAGGAAGGAAGAGTGTTTGTGTACATCAACTCTGGCTCGGGAGCAGT
AATGAATGCAATGGAAACAAACCTCGTTGGAAGTGACAAATATGCTGCAAGATTTGGGGA
ATCTATAGTTAATCTTGGCGACATTGACAATGATGGCTTTGAAGATGTTGCTATCGGAGC
TCCACAAGAAGATGACTTGCAAGGTGCTATTTATATTTACAATGGCCGTGCAGATGGGAT
CTCGTCAACCTTCTCACAGAGAATTGAAGGACTTCAGATCAGCAAATCGTTAAGTATGTT
TGGACAGTCTATATCAGGACAAATTGATGCAGATAATAATGGCTATGTAGATGTAGCAGT
TGGTGCTTTTCGGTCTGATTCTGCTGTCTTGCTAAGGACAAGACCTGTAGTAATTGTTGA
CGCTTCTTTAAGCCACCCTGAGTCAGTAAATAGAACGAAATTTGACTGTGTTGAAAATGG
ATGGCCTTCTGTGTGCATAGATCTAACACTTTGTTTCTCATATAAGGGCAAGGAAGTTCC
AGGTTACATTGTTTTGTTTTATAACATGAGTTTGGATGTGAACAGAAAGGCAGAGTCTCC
ACCAAGATTCTATTTCTCTTCTAATGGAACTTCTGACGTGATTACAGGAAGCATACAGGT
GTCCAGCAGAGAAGCTAACTGTAGAACACATCAAGCATTTATGCGGAAAGATGTGCGGGA
CATCCTCACCCCAATTCAGATTGAAGCTGCTTACCACCTTGGTCCTCATGTCATCAGTAA
ACGAAGTACAGAGGAATTCCCACCACTTCAGCCAATTCTTCAGCAGAAGAAAGAAAAAGA
CATAATGAAAAAAACAATAAACTTTGCAAGGTTTTGTGCCCATGAAAATTGTTCTGCTGA
TTTACAGGTTTCTGCAAAGATTGGGTTTTTGAAGCCCCATGAAAATAAAACATATCTTGC
TGTTGGGAGTATGAAGACATTGATGTTGAATGTGTCCTTGTTTAATGCTGGAGATGATGC
ATATGAAACGACTCTACATGTCAAACTACCCGTGGGTCTTTATTTCATTAAGATTTTAGA
GCTGGAAGAGAAGCAAATAAACTGTGAAGTCACAGATAACTCTGGCGTGGTACAACTTGA
CTGCAGTATTGGCTATATATATGTAGATCATCTCTCAAGGATAGATATTAGCTTTCTCCT
GGATGTGAGCTCACTCAGCAGAGCGGAAGAGGACCTCAGTATCACAGTGCATGCTACCTG
TGAAAATGAAGAGGAAATGGACAATCTAAAGCACAGCAGAGTGACTGTAGCAATACCTTT
AAAATATGAGGTTAAGCTGACTGTTCATGGGTTTGTAAACCCAACTTCATTTGTGTATGG
ATCAAATGATGAAAATGAGCCTGAAACGTGCATGGTGGAGAAAATGAACTTAACTTTCCA
TGTTATCAACACTGGCAATAGTATGGCTCCCAATGTTAGTGTGGAAATAATGGTACCAAA
TTCTTTTAGCCCCCAAACTGATAAGCTGTTCAACATTTTGGATGTCCAGACTACTACTGG
AGAATGCCACTTTGAAAATTATCAAAGAGTGTGTGCATTAGAGCAGCAAAAGAGTGCAAT
GCAGACCTTGAAAGGCATAGTCCAGTTCTTGTCCAAGACTGATAAGAGGCTATTGTACTG
CATAAAAGCTGATCCACATTGTTTAAATTTCTTGTGTAATTTTGGGAAAATGGAAAGTGG
AAAAGAAGCCAGTGTTCATATCCAACTGGAAGGCCGGCCATCCATTTTAGAAATGGATGA
GACTTCAGCACTCAAGTTTGAAATAAGAGCAACAGGTTTTCCAGAGCCAAATCCAAGAGT
AATTGAACTAAACAAGGATGAGAATGTTGCGCATGTTCTACTGGAAGGACTACATCATCA
AAGACCCAAACGTTATTTCACCATAGTGATTATTTCAAGTAGCTTGCTACTTGGACTTAT
TGTACTTCTGTTGATCTCATATGTTATGTGGAAGGCTGGCTTCTTTAAAAGACAATACAA
ATCTATCCTACAAGAAGAAAACAGAAGAGACAGTTGGAGTTATATCAACAGTAAAAGCAA
TGATGATTAAGGACTTCTTTCAAATTGAGAGAATGGAAAACAGACTCAGGTTGTAGTAAA
GAAATTTAAAAGACACTGTTTACAAGAAAAAATGAATTTTGTTTGGACTTCTTTTACTCA
TGATCTTGTGACATATTATGTCTTCATGCAAGGGGAAAATCTCAGCAATGATTACTCTTT
GAGATAGAAGAACTGCAAAGGTAATAATACAGCCAAAGATAATCTCTCAGCTTTTAAATG
GGTAGAGAAACACTAAAGCATTCAATTTATTCAAGAAAAGTAAGCCCTTGAAGATATCTT
GAAATGAAAGTATAACTGAGTTAAATTATACTGGAGAAGTCTTAGACTTGAAATACTACT
TACCATATGTGCTTGCCTCAGTAAAATGAACCCCACTGGGTGGGCAGAGGTTCATTTCAA
ATACATCTTTGATACTTGTTCAAAATATGTTCTTTAAAAATATAATTTTTTAGAGAGCTG
TTCCCAAATTTTCTAACGAGTGGACCATTATCACTTTAAAGCCCTTTATTTATAATACAT
TTCCTACGGGCTGTGTTCCAACAACCATTTTTTTTCAGCAGACTATGAATATTATAGTAT
TATAGGCCAAACTGGCAAACTTCAGACTGAACATGTACACTGGTTTGAGCTTAGTGAAAT
GACTTCTGGATAATTATTTTTTTATAATTATGGATTTCACCATCTTTCTTTCTGTATATA
TACATGTGTTTTTATGTAGGTATATATTTACCATTCTTCCTATCTATTCTTCCTATAACA
CACCTTTATCAAGCATACCCAGGAGTAATCTTCAAATCTTTTGTTATATTCTGAAACAAA
AGATTGTGAGTGTTGCACTTTACCTGATACATGCTGATTTAGAAAATACAGAAACCATAC
CTCACTAATAACTTTAAAATCAAAGCTGTGCAAAGACTAGGGGGCCTATACTTCATATGT
ATTATGTACTATGTAAAATATTGACTATCACACAACTATTTCCTTGGATGTAATTCTTTG
TTACCCTTTACAAGTATAAGTGTTACCTTACATGGAAACGAAGAAACAAAATTCATAAAT
TTAAATTCATAAATTTAGCTGAAAGATACTGATTCAATTTGTATACAGTGAATATAAATG
AGACGACAGCAAAATTTTCATGAAATGTAAAATATTTTTATAGTTTGTTCATACTATATG
AGGTTCTATTTTAAATGACTTTCTGGATTTTAAAAAAAAAAAAAAAAAAAACTCGAC
>OriGene 5' read for NM_000885 unedited
NGGGTTCACATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGCCTTCCT
TTAGCCCGCTGGCGCCGGNCACGCTGCGCCTCATCTCTTGGGGCGTTCTTCCCCGTTGGC
CAACCGTCGCATCCCGTGCAACTTTGGGGTAGTGGCCGTTTAGTGTTGAATGTTCCCCAC
CGAGAGCGCATGGCTTGGGAAGCGAGGCGCGAACCCGGCCCCCGAAGGGCCGCCGTCCGG
GAGACGGTGATGCTGTTGCTGTGCCTGGGGGTCCCGACCGGCCGCCCCTACAACGTGGAC
ACTGAGAGCGCGCTGCTTTACCAGGGCCCCCACAACACGCTGTTCGGCTACTCGGTCGTG
CTGCACAGCCACGGGGCGAACCGATGGCTCCTAGTGGGTGCGCCCACTGCCAACTGGCTC
GCCAACGCTTCAGTGATCAATCCCGGGGCGATTTACAGATGCAGGATCGGAAAGAATCCC
GGCCAGACGTGCGAACAGCTCCAGCTGGGTAGCCCTAATGGAGAACCTTGTGGAAAGACT
TGTTTGGAAGAGAGAGACAATCAGTGGTTGGGGGTCACACTTTCCAGACAGCCAGGAGAA
AATGGATCCATCGTGACTTGTGGGCATAGATGGAAAAATATATTTTACATAAAGAATGAA
AATAAGCTCCCCACTGGTGGTTGCTATGGAGTGCCCCCTGATTTACGAACAGAACTGAGT
AAAAGAATAGCTCCGTGTTATCAAGAATATGTGAAAAAAATTTGGAGAAAATTNTGCATC
ATGTCAAGCTGGAATATCCAGTTTTTACACAAAGGATTTAATTGTGATGGGGGCCCCAGG
ATCATCTTACTGGACTGGCTCTCTTTTGTCTACAATATACTACAAATAAATACAAGCCTT
TT
>OriGene 3' read for NM_000885 unedited
ATGAACTGCGGCCGCAATCTAGAGTCGAGTTACTTTTTTTTTTTTTTTTTAACTATCCAG
AAAGTCTACTTAAAATAGAACCTCATATAGTATGAACAAACTATAAACTTATTCTAACTT
TATATGAAAATTTTGCTGTCTTCCTAATTATATTACTTGTATACAAATTGAATCAGTATC
TTTCAGCTAAATTTATGAATTTAAATTTATGAATTTTGTTTCTTCGTTTCCATGTAGCGT
ATCACTTATTCTTGCAAAGGGACTACATAATATTACTTATAAGGAAATAGTTGATTGATA
CTCATATATTTCTCATACATCATAATATATAATAAGCATAGGCCCCTTATTCTTTAGTAC
ACTTTTGATTATATAGTTATTACTGAATTATCGTTTCTGTATTATCTAAAACAGCATGTA
ACTACCAAAGTGCAACACATACAATCTTTTGTTTCAGAATATAACAAAAGATTTGAAGAT
TACTCCTGGGATATTCTTGATCAAATTGTGTTATAGGTAGAATACTATAGGAAAAATATC
ACATATCTACCTACATATAAACACCTGTATATATACAGAATGAAAGATGGTGAAATCACT
AATTATTATCTAATAATTATCCATAAGTCATTTNACTAAGCTCAAACCAGTGTACATGTT
CAATCTGAAGTTTGCCAGATTGGCCTATAATACTATATAATTCATAGCCTGATGANAAAA
AATGGATGCTGGNACACAGCCCGTAGGAAATTATTATAAAACTAGGCTTTAAGTGATAAT
GGTCACTCGTTATAAATTTGTGACAGCATTTTAAATATATATTTTTAAGAAATTCTTCCT
CACGACNAAATAGAACTTGAAGAAACNNNGNNANCAGGGGATTAATTTANTGNNGGNGNN
CTNGGNNNGNNNNNNNNAGNNNANNNNTNNNNNNAATTNANATNNATATTATTATCTGAA
TTTNAGGGCCTACTTCTGACTAAAGAGCTTAATTTTTATAATTACAG
Restriction Sites NotI-NotI     
ACCN NM_000885
Insert Size 4760 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000885.4, NP_000876.3
RefSeq Size 6082 bp
RefSeq ORF 3099 bp
Locus ID 3676
Cytogenetics 2q31.3
Domains FG-GAP
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Leukocyte transendothelial migration, Regulation of actin cytoskeleton
Gene Summary 'The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]'
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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