HTR2C (NM_000868) Human Untagged Clone

CAT#: SC119615

HTR2C (untagged)-Human 5-hydroxytryptamine (serotonin) receptor 2C (HTR2C)


  "NM_000868" in other vectors (6)

Reconstitution Protocol

USD 770.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol HTR2C
Synonyms 5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC119615 sequence for NM_000868 edited (data generated by NextGen Sequencing)
ATGGTGAACCTGAGGAATGCGGTGCATTCATTCCTTGTGCACCTAATTGGCCTATTGGTT
TGGCAATGTGATATTTCTGTGAGCCCAGTAGCAGCTATAGTAACTGACATTTTCAATACC
TCCGATGGTGGACGCTTCAAATTCCCAGACGGGGTACAAAACTGGCCAGCACTTTCAATC
GTCATCATAATAATCATGACAATAGGTGGCAACATCCTTGTGATCATGGCAGTAAGCATG
GAAAAGAAACTGCACAATGCCACCAATTACTTCTTAATGTCCCTAGCCATTGCTGATATG
CTAGTGGGACTACTTGTCATGCCCCTGTCTCTCCTGGCAATCCTTTATGATTATGTCTGG
CCACTACCTAGATATTTGTGCCCCGTCTGGATTTCTTTAGATGTTTTATTTTCAACAGCG
TCCATCATGCACCTCTGCGCTATATCGCTGGATCGGTATGTAGCAGTACGTAATCCTGTT
GAGCATAGCCGTTTCAATTCGCGGACTAAGGCCATCATGAAGATTGCTATTGTTTGGGCA
ATTTCTATAGGTGTATCAGTTCCTATCCCTGTGATTGGACTGAGGGACGAAGAAAAGGTG
TTCGTGAACAACACGACGTGCGTGCTCAACGACCCAAATTTCGTTCTTATTGGGTCCTTC
GTAGCTTTCTTCATACCGCTGACGATTATGGTGATTACGTATTGCCTGACCATCTACGTT
CTGCGCCGACAAGCTTTGATGTTACTGCACGGCCACACCGAGGAACCGCCTGGACTAAGT
CTGGATTTCCTGAAGTGCTGCAAGAGGAATACGGCCGAGGAAGAGAACTCTGCAAACCCT
AACCAAGACCAGAACGCACGCCGAAGAAAGAAGAAGGAGAGACGTCCTAGGGGCACCATG
CAGGCTATCAACAATGAAAGAAAAGCTTCGAAAGTCCTTGGGATTGTTTTCTTTGTGTTT
CTGATCATGTGGTGCCCATTTTTCATTACCAATATTCTGTCTGTTCTTTGTGAGAAGTCC
TGTAACCAAAAGCTCATGGAAAAGCTTCTGAATGTGTTTGTTTGGATTGGCTATGTTTGT
TCAGGAATCAATCCTCTGGTGTATACTCTGTTCAACAAAATTTACCGAAGGGCATTCTCC
AACTATTTGCGTTGCAATTATAAGGTAGAGAAAAAGCCTCCTGTCAGGCAGATTCCAAGA
GTTGCCGCCACTGCTTTGTCTGGGAGGGAGCTTAATGTTAACATTTATCGGCATACCAAT
GAACCGGTGATCGAGAAAGCCAGTGACAATGAGCCCGGTATAGAGATGCAAGTTGAGAAT
TTAGAGTTACCAGTAAATCCCTCCAGTGTGGTTAGCGAAAGGATTAGCAGTGTGTGA

Clone variation with respect to NM_000868.2
466 a=>g;478 a=>g
>OriGene 5' read for NM_000868 unedited
TTTTGGNNTTGTCGAAATTTTGTATACGACTCACTATAGGCGGCCCGCGATTCGGCACGA
GGGAAGAAGCCAAACCTAGCCGGGGGGCGCACGGTCACCCAAGGAGGTCGACTCGCCGGC
GCTTCCTATCGCGCCGAGCTCCCTCCATTCCTCTCCCTCCGCCGAGGCGCGAGGTTGCGG
CGCGCAGCGCAGCGCAGCTCAGCGCACCGACTGCCGCGGGCTCCGCTGGGCGATTGCAGC
CGAGTCCGTTTCTCGTCTAGCTGCCGCCGCGGCGACCGCTGCCTGGTCTTCCTCCCGGAC
GCTAGTGGGTTATCAGCTAACACCCGCGAGCATCTATAACATAGGCCAACTGACGCCATC
CTTCANAAACAACTGTCTGGGAAAAAAAGAATAAAAAGTAGTGTGAGAGCAGAAAACGTG
ATTGAAACACGACCAATCTTTCTTCAGTGCCAAAGGGTGGAAAAGAAAGGGATGATATGA
TGAACCTAGCCTGTTAATTNTCGTCTTCTCAATTTTAAACTTTGGGTGCTTAAGACTGAA
GCAATCATGGTGAACCTGNAGAATGCGGNGCATTCATTCCTTGTGCACCTATTGGCCTAT
TGGTTTGGCAATGTGATATTTCTGGGAGCCCAATAGCAGCTATAGGAACTGGCATTTTTC
ATACCCTCCGAGGGGGGGACGCTTCCAAATNCCCAGACGGGGGACAAAACTGGGCAGCCC
TTTCAATCGGCATCCTAAAATCATGACAAAAGGTGGCACATTCCTGGGATCATGGCGGGA
AGCCTGGGAAAGAAACTGGCCATGGCCCCCATTACTTTTTAAGGCCCTAGCCACTGTGAA
TGCCTATGGGACAACCTGGGATGCCCCTGGCCTTCTG
>OriGene 3' read for NM_000868 unedited
TTGCATTACGACGACCCCGCTATCTACATGCAGCTCTTTTTTTTTTTTTTTCAACACTTA
ATAGATTTAATAAATCAATAGGCAAGTCTCATAAAACCTGTAGTGCATAACATACAGGAA
TTAGGAATAAACACAACACTTTGCAACCATTCACAAAAAACCCATTTGACAAAGGGAGAA
GACTTACGGTAAATTAGTATAAGGCAGTCTGTTGCTCGTGTCTTACACAGATATACATAT
ATAATAATACATCAAAATGATTCGTTTGATGGCAAATTCATCACCTTTACAATTATCACA
TGGACTTGTTTAAAACATTTATAAAAGTTTGTAAATTTAACATTGAAGGGTAAGATTTAT
ATCCAAACGAGTATATTTGTTTCATACCAAACTGCTCCAAACTTACGAGTAGCACACAAC
TTGAGGATAATTACCAGGTTGGGCACTATTAAGTACTACTACTTGCTGACACAGGAATCA
TTAACAAATGTGCTGTGAGCTATTATCATTTCACTTATTGCTATTACTTTTGGAAATCTG
CGATTTATATTTTGTTCATTTGAAAAACATGGGCTATGAGCTTGCCCTGATAGTTCACAT
ATCAGAGGTCTCCAGGTCTTGCTAACACTCACACTACTTCACACCTGAATGCATGGCCCT
TTTTAAGGAAAGGCCGAACGGATTTCTCTTCCATCCCTTCTTTCTATAACCTTATTTCGC
CCTACTTATAATACAAATCCAGGGGATTATTGCACCATCACATGGCCATACTTGCGAGCA
ACCATCTTTNAGTGCCCCAACCTAAGGCTTAAAAGCATGGCCGGGCTACCTTTAAGCACA
TTCTCATTTCCGGCAAAGAACAAAATGAATCAACTCTCGGCTCTCTTAAACGTATTTGTA
ACATCCCCTTCAACAAAACCTAACTGCCCAGGGAGGAGAAAATGGACCTCCTGCTACAAT
CTGGCACTGTCCCACAATATGCATACG
Restriction Sites NotI-NotI     
ACCN NM_000868
Insert Size 4700 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000868.1, NP_000859.1
RefSeq Size 4775 bp
RefSeq ORF 1377 bp
Locus ID 3358
Cytogenetics Xq23
Protein Families Druggable Genome, GPCR, Transmembrane
Protein Pathways Calcium signaling pathway, Gap junction, Neuroactive ligand-receptor interaction
Gene Summary 'This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]'
Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a). This variant may undergo RNA editing.

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