ALDH2 (NM_000690) Human Untagged Clone

CAT#: SC119703

ALDH2 (untagged)-Human aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), nuclear gene encoding mitochondrial protein, transcript variant 1


  "NM_000690" in other vectors (6)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol ALDH2
Synonyms ALDH-E2; ALDHI; ALDM
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC119703 sequence for NM_000690 edited (data generated by NextGen Sequencing)
ATGTTGCGCGCTGCCGCCCGCTTCGGGCCCCGCCTGGGCCGCCGCCTCTTGTCAGCCGCC
GCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTTC
ATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCC
ACTGGAGAGGTCATCTGTCAGGTAGCTGAAGGGGACAAGGAAGATGTGGACAAGGCAGTG
AAGGCCGCCCGGGCCGCCTTCCAGCTGGGCTCACCTTGGCGCCGCATGGACGCATCACAC
AGGGGCCGGCTGCTGAACCGCCTGGCCGATCTGATCGAGCGGGACCGGACCTACCTGGCG
GCCTTGGAGACCCTGGACAATGGCAAGCCCTATGTCATCTCCTACCTGGTGGATTTGGAC
ATGGTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACC
ATCCCCATTGACGGAGACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGG
CAGATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAGCTGGGCCCAGCCTTG
GCAACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTAT
GTGGCCAACCTGATCAAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGA
TTTGGCCCCACGGCTGGGGCCGCCATTGCCTCCCATGAGGATGTGGACAAAGTGGCATTC
ACAGGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAAG
AGAGTGACCTTGGAGCTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATG
GATTGGGCCGTGGAACAGGCCCACTTCGCCCTGTTCTTCAACCAGGGCCAGTGCTGCTGT
GCCGGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGAGCGGAGCGTT
GCCCGGGCCAAGTCTCGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCG
CAGGTGGATGAAACTCAGTTTAAGAAGATCCTCGGCTACATCAACACGGGGAAGCAAGAG
GGGGCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCCC
ACTGTGTTTGGAGATGTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCA
GTGATGCAGATCCTGAAGTTCAAGACCATAGAGGAGGTTGTTGGGAGAGCCAACAATTCC
ACGTACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTCC
CAGGCCCTCCAGGCGGGCACTGTGTGGGTCAACTGCTATGATGTGTTTGGAGCCCAGTCA
CCCTTTGGTGGCTACAAGATGTCGGGGAGTGGCCGGGAGTTGGGCGAGTACGGGCTGCAG
GCATACACTGAAGTGAAAACTGTCACAGTCAAAGTGCCTCAGAAGAACTCATAA

Clone variation with respect to NM_000690.3
>OriGene 5' read for NM_000690 unedited
GGATTTTGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGCCGCTGCGAT
GTTGCGCGCTGCCGCCCGCTTCGGGCCCCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGC
CACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTTCAT
AAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCAC
TGGAGAGGTCATCTGTCAGGTAGCTGAAGGGGACAAGGAAGATGTGGACAAGGCAGTGAA
GGCCGCCCGGGCCGCCTTCCAGCTGGGCTCACCTTGGCGCCGCATGGACGCATCACACAG
GGGCCGGCTGCTGAACCGCCTGGCCGATCTGATCGAGCGGGACCGGACCTACCTGGCGGC
CTTGGAGACCCTGGACAATGGCAAGCCCTATGTCATCTCCTACCTGGTGGATTTGGACAT
GGTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACCAT
CCCCATTGACGGAGACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGGCA
GATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAGCTGGGCCCAGCCTTGGC
AACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAAACACCCCTCACCGCCCTCTATGT
GGCCAACCTGATCAGGGAGCTGGCTTTCCCCCTGGTGTGTCAACATTGTGCCTGGATTTG
CCCCCACGGTGGGGCCGCCATTGCCTCCATGAGGATGTGGACAAGTGGCATCACCAGCTC
ACTGAGATGGCCGGTAACCACAGGTGCTGCT
>OriGene 3' read for NM_000690 unedited
CGCAATCTATAGTCGAGTNNTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTAAAAACAGCTAGTTTTTAATGAATCTTACCCCAAAATACAAAGCAGGGGGGAAC
AGTTGCCTTAATGGGGATATAATTGGAAACAATAGCTTTTTTTTCCCCTATAAACTCGAG
TTATAGGAAGCGTTTCAAAAAGAGGATAACACATTTGAATCTATTTTTTAAAAATCATCC
TGAAAGCTAACAGTATTGGTGGCGTTTAAAAGGGTCCTCATATACTCTTACCCTCAGCCA
ACCCACCATGTTTATCAATTAAAATTCTAAAACTTTCTTGACCCAAAAAATTTTGGAGGA
AAAATTTCTTTTTTCAAATTTTCAGCACGCAAGGATCATTTTTCTTGGTTTTGGGGCTGA
TCTTGCTGAACTTTCCATCAATGGCTGAGGGAGGAAACCTGCACGATCCTTATGAGTCCT
TTTGAGGCACTTTGACTGGGACAGTTTTCATTTCAGGGATTGCCTGGAGACCGTTCTCCG
CCAACTCCGGAGCTTTCCCGATTTTTTGTTCCTTGAAGGGTGTTTGGGTTCTGTGTGTTC
TGTGTGGGCCCCTTGTGTGTCGTCGTGGTGGCGTGGTTTGGCCTGGGTGGTGGCACGGGC
TGGTGGGTGGGTGGGGGCGGCGTCTGCAGGCTGGAGGACTCCACTGCCTGCCCCAGGCCT
GCGTGTTGCGGGCACTACTTGGCCCCCGTCGCCCCCTGTTTCTGCGTGTTTTCTCCTTGT
CCCTCTCCCCCCTCCTCCTGTGCTCTTTTGCCCGCCTCGTCTTTTTCTCCTCACGCTTTC
TCCTACCACTCTTTGGCGTGAACATACTTTCTCCTATCTCTCACCCCGCTCCGGTCCCCG
CCCCCCCTCGCGGCCGCTCCGCCTTCTTACTCCCCGCCCCCTCCCTC
Restriction Sites NotI-NotI     
ACCN NM_000690
Insert Size 2100 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000690.2, NP_000681.2
RefSeq Size 2445 bp
RefSeq ORF 1554 bp
Locus ID 217
Cytogenetics 12q24.12
Domains aldedh
Protein Families Druggable Genome
Protein Pathways Arginine and proline metabolism, Ascorbate and aldarate metabolism, beta-Alanine metabolism, Butanoate metabolism, Fatty acid metabolism, Glycerolipid metabolism, Glycolysis / Gluconeogenesis, Histidine metabolism, Limonene and pinene degradation, Lysine degradation, Metabolic pathways, Propanoate metabolism, Pyruvate metabolism, Tryptophan metabolism, Valine, leucine and isoleucine degradation
Gene Summary 'This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]'
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

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