CD59 (NM_000611) Human Untagged Clone

CAT#: SC119785

CD59 (untagged)-Human CD59 molecule, complement regulatory protein (CD59), transcript variant 2


  "NM_000611" in other vectors (6)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CD59
Synonyms 1F5; 16.3A5; EJ16; EJ30; EL32; G344; HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC119785 sequence for NM_000611 edited (data generated by NextGen Sequencing)
ATGGGAATCCAAGGAGGGTCTGTCCTGTTCGGGCTGCTGCTCGTCCTGGCTGTCTTCTGC
CATTCAGGTCATAGCCTGCAGTGCTACAACTGTCCTAACCCAACTGCTGACTGCAAAACA
GCCGTCAATTGTTCATCTGATTTTGATGCGTGTCTCATTACCAAAGCTGGGTTACAAGTG
TATAACAAGTGTTGGAAGTTTGAGCATTGCAATTTCAACGACGTCACAACCCGCTTGAGG
GAAAATGAGCTAACGTACTACTGCTGCAAGAAGGACCTGTGTAACTTTAACGAACAGCTT
GAAAATGGTGGGACATCCTTATCAGAGAAAACAGTTCTTCTGCTGGTGACTCCATTTCTG
GCAGCAGCCTGGAGCCTTCATCCCTAA

Clone variation with respect to NM_000611.5
>OriGene 5' read for NM_000611 unedited
GGTGCAAATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGGAGGATCCT
GGGCGCCGCCAGTCTTTAGCACCAGTTGGTGTAGGAGTTGAGACCTACTTCACAGTAGTT
CTGTGGACAATCACAATGGGAATCCAAGGAGGGTCTGTCCTGTTCGGGCTGCTGCTCGTC
CTGGCTGTCTTCTGCCATTCAGGTCATAGCCTGCAGTGCTACAACTGTCCTAACCCAACT
GCTGACTGCAAAACAGCCGTCAATTGTTCATCTGATTTTGATGCGTGTCTCATTACCAAA
GCTGGGTTACAAGTGTATAACAAGTGTTGGAAGTTTGAGCATTGCAATTTCAACGACGTC
ACAACCCGCTTGAGGGAAAATGAGCTAACGTACTACTGCTGCAAGAAGGACCTGTGTAAC
TTTAACGAACAGCTTGAAAATGGTGGGACATCCTTATCAGAGAAAACAGTTCTTCTGCTG
GTGACTCCATTTCTGGCAGCAGCCTGGAGCCTTCATCCCTAAGTCAACACCAGGAGAGCT
TCTCCCAAACTCCCCGTTCCTGCGTAGTCCGCTTTCTCTTGCTGCCACATTCTAAAGGCT
TGATATTTTCCAAATGGATCCTGTTGGGAAAGAATAAAATTAGCTTGAGCAACCTGNCTA
AGATAGAGGGGCTCTGGGAGACTTTGAAGACCAGTCCTGTTTGCAGGGAAGCCCCACTTG
AAGAAAGAAGTCTAAGAGTGAAGTANGTGTGACTTGAACTAGATTGCATGCTTCCTCCTT
TGCTCTTGGGAAGACCACTNTGCAGTGACAGCTTGAGTGGGGTTCTCTGCAGCCCTCAGA
TTATTTTTCCTCCTGCTCCTTGNATGTAGCCAGTTAGCATCATTAGTACATCTTTGAAGG
TGGGGC
>OriGene 3' read for NM_000611 unedited
NAATCCTAGCTATGNCCGCGGCCGCTATCTAGATCGAGTTTTTTTTTTTTTTTTTTCGGT
TTGTCCAACAGATATAATCAAGGGTTTTTTTTCAACATTAATCAAGAAATTCCTCCATCT
GCAAAAGTCAGCCTATGCCATTAAATACAGCCAAGATCATAAAATACAAATGTCATTAGG
TCTACTGAATCTTGAGATTCATTCACTAGAATACACAGGGAAAAGGAAAAAGTTTGCCCT
TGTGAAAGGTGTGTATCATTTTTTAAAAGAGCTTCTGAAAGCCTCAAACATCTGTGAGTG
TGCTAAGAGCCGTTACAAAGGTATTTTATACAATCTATGCTGAGTCAGCTAGGAGTTAGC
AGGAGGCTGGATGCAGATGGTAAAACATACCCCTGCAGATCTGTTGTTATTAAGGATGAC
CTTTGGAAGTCTCAAACTGTAACCACAAAGGGTGTCCCCACTGCATTCATACTATATACA
CACATACCTGAACTGCCTTTCTACCAGTAACATTTAAAATAAGCACACTTAATACTGCCA
GTCACATGTAGTAGAGTGTTCACTCTGTAACTGTGTGTGGCAAAGCCAAGATATCCTACC
ATTCCAATAAAAAAAAGGCAAGGAAATAGCTTTAACACACCATTGATGTATGCTATTACA
CTTTTCCAGTGGAAGATAACAAAGCCCATATAAAATTTAAAGACAGAGGAAAAACTCGAT
TTTCAGCCACTTGTACCTCTCTAAGTTTTCATGCCCTGCTATCTGGAACACTTCCCCACT
TCCCTGCCAGAAGTCCTCTAGCTCTGCATTAAGGGATCTGNTGTCCCTGACTGACACCCC
ATATGGAACATTTGCCATGCCTNCATGCACACGGGATCCCTGAAGTTATGAN
Restriction Sites NotI-NotI     
ACCN NM_000611
Insert Size 1900 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000611.4, NP_000602.1
RefSeq Size 7633 bp
RefSeq ORF 387 bp
Locus ID 966
Cytogenetics 11p13
Domains LU
Protein Families Druggable Genome
Protein Pathways Complement and coagulation cascades, Hematopoietic cell lineage
Gene Summary 'This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-8) encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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