IL6R (NM_000565) Human Untagged Clone

CAT#: SC119840

IL6R (untagged)-Human interleukin 6 receptor (IL6R), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IL6R
• Synonyms: CD126; gp80; HIES5; IL-6R-1; IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_000565 edited
  GAATTCGGCACGAGGCGGCGCGGGGCCGAGGGACTCGCAGTGTGTGTAGAGAGCCGGGCT
  CCTGCGGATGGGGGCTGCCCCCGGGGCCTGAGCCCGCCTGCCCGCCCACCGCCCCGCCCC
  GCCCCTGCCACCCCTGCCGCCCGGTTCCCATTAGCCTGTCCGCCTCTGCGGGACCATGGA
  GTGGTAGCCGAGGAGGAAGCATGCTGGCCGTCGGCTGCGCGCTGCTGGCTGCCCTGCTGG
  CCGCGCCGGGAGCGGCGCTGGCCCCAAGGCGCTGCCCTGCGCAGGAGGTGGCGAGAGGCG
  TGCTGACCAGTCTGCCAGGAGACAGCGTGACTCTGACCTGCCCGGGGGTAGAGCCGGAAG
  ACAATGCCACTGTTCACTGGGTGCTCAGGAAGCCGGCTGCAGGCTCCCACCCCAGCAGAT
  GGGCTGGCATGGGAAGGAGGCTGCTGCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACT
  ATTCATGCTACCGGGCCGGCCGCCCAGCTGGGACTGTGCACTTGCTGGTGGATGTTCCCC
  CCGAGGAGCCCCAGCTCTCCTGCTTCCGGAAGAGCCCCCTCAGCAATGTTGTTTGTGAGT
  GGGGTCCTCGGAGCACCCCATCCCTGACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTC
  AGAACAGTCCGGCCGAAGACTTCCAGGAGCCGTGCCAGTATTCCCAGGAGTCCCAGAAGT
  TCTCCTGCCAGTTAGCAGTCCCGGAGGGAGACAGCTCTTTCTACATAGTGTCCATGTGCG
  TCGCCAGTAGTGTCGGGAGCAAGTTCAGCAAAACTCAAACCTTTCAGGGTTGTGGAATCT
  TGCAGCCTGATCCGCCTGCCAACATCACAGTCACTGCCGTGGCCAGAAACCCCCGCTGGC
  TCAGTGTCACCTGGCAAGACCCCCACTCCTGGAACTCATCTTTCTACAGACTACGGTTTG
  AGCTCAGATATCGGGCTGAACGGTCAAAGACATTCACAACATGGATGGTCAAGGACCTCC
  AGCATCACTGTGTCATCCACGACGCCTGGAGCGGCCTGAGGCACGTGGTGCAGCTTCGTG
  CCCAGGAGGAGTTCGGGCAAGGCGAGTGGAGCGAGTGGAGCCCGGAGGCCATGGGCACGC
  CTTGGACAGAATCCAGGAGTCCTCCAGCTGAGAACGAGGTGTCCACCCCCATGCAGGCAC
  TTACTACTAATAAAGACGATGATAATATTCTCTTCAGAGATTCTGCAAATGCGACAAGCC
  TCCCAGTGCAAGCTTCTTCTTCAGTACCACTGCCCACATTCCTGGTTGCTGGAGGGAGCC
  TGGCCTTCGGAACGCTCCTCTGCATTGCCATTGTTCTGAGGTTCAAGAAGACGTGGAAGC
  TGCGGGCTCTGAAGGAAGGCAAGACAAGCATGCATCCGCCGTACTCTTTGGGGCAGCTGG
  TCCCGGAGAGGCCTCGACCCACCCCAGTGCTTGTTCCTCTCATCTCCCCACCGGTGTCCC
  CCAGCAGCCTGGGGTCTGACAATACCTCGAGCCACAACCGACCAGATGCCAGGGACCCAC
  GGAGCCCTTATGACATCAGCAATACAGACTACTTCTTCCCCAGATAGCTGGCTGGGTGGC
  ACCAGCAGCCTGGACCCTGTGGATGACAAAACACAAACGGGCTCAGCAAAAGATGCTTCT
  CACTGCCATGCCAGCTTATCTCAGGGGTGTGCGGCCTTTGGCTTCACGGAAGAGCCTTGC
  GGAAGGTTCTACGCCAGGGGAAAATCAGCCTGCTCCAGCTGTTCAGCTGGTTGAGGTTTC
  AAACCTCCCTTTCCAAATGCCCAGCTTAAAGGGGTTAGAGTGAACTTGGGCCACTGTGAA
  GAGAACCATATCAAGACTCTTTGGACACTCACATGGACACTCAAAAGCTGGGCAGGTTGG
  TGGGGGCCTCGGTGTGGAGAAGCGGCTGGCAGCCCACCCCTCAACACCTCTGCACAAGCT
  GCACCCTCAGGCAGGTGGGATGGATTTCCAGCCAAAGCCTCCTCCAGCCGCCATGCTCCT
  GGCCCACTGCATCGTTTCATCTTCCAACTCAAACTCTTAAAACCCAAGTGCCTTAGCAAA
  TTCTGTTTTTCTAGGCCTGGGGACGGCTTTTACTTAAACCGCCAAGGCTGGGGGAAGAAG
  CTCTCTCCTCCCTTTCTTCCCTACAGTTGAAAAACAGCTGAGGGTGAGTGGGTGAATAAT
  ACAGTATCTCAGGGCCTGGTCGTTTTCAACAGAATTATAATTAGTTCCTCATTAGCATTT
  TGCTAAATGTGAATGATGATCCTAGGCATTTGCTGAATACAGAGGCAACTGCATTGGCTT
  TGGGTTGCAGGACCTCAGGTGAGAAGCAGAGGAAGGAGAGGAGAGGGGCACAGGGTCTCT
  ACCATCCCCTGTAGAGTGGGAGCTGAGTGGGGGATCACAGCCTCTGAAAACCAATGTTCT
  CTCTTCTCCACCTCCCACAAAGGAGAGCTAGCAGCAGGGAGGGCTTCTGCCATTTCTGAG
  ATCAAAACGGTTTTACTGCAGCTTTGTTTGTTGTCAGCTGAACCTGGGTAACTAGGGAAG
  ATAATATTAAGGAAGACAATGTGAAAAGAAAAATGAGCCTGGCAAGAATGCGTTTAAACT
  TGGTTTTTAAAAAAACTGCTGACTGTTTTCTCTTGAGAGGGTGGAATATCCAATATTCGC
  TGTGTCAGCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCAAAAAGCATA
  AAAATTAGCCAAGTGTGGTAGAGTGTGCCTGAAGTCCCAGATACTTGGGGGGCTGAGGTG
  GGAGGATCTCTTGAGCCTGGGAGGTCAAGGCTGCAGTGAGCCGAGATTGCACCACTGCAC
  TCCAGCCTGGGTGACAGAGCAAGTGAGACCCTGTCTCAAAAAAAGAAAAAAAAAAAAAAA
  AAAAAACTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000565 unedited
  CACATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGCACGAGGCGGCGCGGGG
  CCGAGGGACTCGCAGTGTGTGTAGAGAGCCGGGCTCCTGCGGATGGGGGCTGCCCCCGGG
  GCCTGAGCCCGCCTGCCCGCCCACCGCCCCGCCCCGCCCCTGCCACCCCTGCCGCCCGGT
  TCCCATTAGCCTGTCCGCCTCTGCGGGACCATGGAGTGGTAGCCGAGGAGGAAGCATGCT
  GGCCGTCGGCTGCGCGCTGCTGGCTGCCCTGCTGGCCGCGCCGGGAGCGGCGCTGGCCCC
  AAGGCGCTGCCCTGCGCAGGAGGTGGCGAGAGGCGTGCTGACCAGTCTGCCAGGAGACAG
  CGTGACTCTGACCTGCCCGGGGGTAGAGCCGGAAGACAATGCCACTGTTCACTGGGTGCT
  CAGGAAGCCGGCTGCAGGCTCCCACCCCAGCAGATGGGCTGGCATGGGAAGGAGGCTGCT
  GCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACTATTCATGCTACCGGGCCGGCCGCCC
  AGCTGGGACTGTGCACTTGCTGGTGGATGTTCCCCCCGAGGAGCCCCAGCTCTCCTGCTT
  CCGGAAGAGCCCCCTCAGCAATGTTGTTTGTGAGTGGGGTCCTCGGAGCACCCCATCCCT
  GACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTCAGAACAGTCCGGCCGAAGACTTCCA
  GGAGCCGTGCCAGTATTCCCAGGAGTCCCCAGAAGTTCTCCTGCCATTTAGCAGTCCCCG
  GNAGGGAGACAGCTCTTTCTACATAGTGTCCTTGTGCGTCGCAGTANTGTCNGGAAGCAA
  GTTCAGCAAACTCAACCTTCAGGGGGTTGGGGGAATCTGCAGCCTGATCCGCCTGNCACA
  TCACATCACTGCCGTGCCAGAACCCCGCTGGCTCAAGTACCTGGCAGACCCACTCCTGGA
  ACTATCTCTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000565 unedited
  GCCGGGCAACCCCCCCCCCCTTCCNNNNNNGNNAATTGTGAACCGGGCCGCATTCTAGAT
  CGGTTTTTTTTTTTTTTTTTTTTTCTTTTTTTGAGACGGGTCTCACTTGCTCTGTCACCC
  AGGCTGGAGTGCAGTGGTGCAATCTCGGCTCACTGCAGCCTTGACCTCCCAGGCTCAAGA
  GATCCTCCCACCTCAGCCCCCCAAGTATCTGGGACTTCAGGCACACTCTACCACACTTGG
  CTAATTTTTATGCTTTTTGTAAAGATGGGGTTTTATCACATTGCCCAGGCTGATCTCAAA
  CTTCTGGACTCAAGTGATCCTCCTGCCTCGACCTCCCGAAGTGCGTGGGCCACCATGCCT
  GGCAGGAAAATATTTTTTCTCTTCCTCCTTTTTCACTTGACTTGGTTTTGGGCTAAACAA
  AGTTATGGTGCTTCCCCCACACCTAAGTAAGTTACTTCTATGCTGACACAGCGAATATTG
  GATATTCCACCCTCTCAAGAGAAAACAGTCAGCAGTTTTTTTAAAAACCAAGTTTACACG
  CATTCTTGCCAGGCTCATTTTTCTTTTCACATTGCCTTCCTTAATATTATCTTCCCCTAG
  TTACCCAGGTTCAGCTGACCACAAACAAAGCTGCAGTAAAACCCGTTTTGATCTCAGAAA
  TGGCAGAAGCCCTCCCTGCTGCTAGCTCTCCCTTTGTGGGAGGTGGGAGAAGAAAGCACA
  TTGGTTTTAAGAGGCCTGGGATCCCCCCTTAGCTCCCACTCTACAGGGGATGTTAGAAAC
  CCTGGGCCCCTTCCTTTACTTTCCCTGGGTTTAACCTGAAGTCCTGCAACCAAAGCCCAT
  GCAGTTGCCTTTGTATTCAGCAAAAGCCTTGGATCATCTTCCCATTTACCAAAAGCCTAG
  GAGAACCTATTTTTATTTTGTTGAAACCACAGCCCTCGGATACTGTTTATTCCCCCCTCC
  CCCTACTGTTTTAATGTTGGGAAAAGAGGGGGAAAACTCTTCC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_000565
• Insert Size: 3000 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000565.2, NP_000556.1
• RefSeq Size: 4176 bp
• RefSeq ORF: 1407 bp
• Locus ID: 3570
• Cytogenetics: 1q21.3
• Domains: ig, IGc2, IG, FN3
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway
• Gene Summary: 'This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020]'
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.