Presenilin 2 (PSEN2) (NM_000447) Human Untagged Clone

CAT#: SC119867

PSEN2 (untagged)-Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 1


  "NM_000447" in other vectors (4)

Reconstitution Protocol

USD 760.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PSEN2
Synonyms AD3L; AD4; CMD1V; PS2; STM2
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_000447 edited
CAGAGCAGGCATTTCCAGCAGTGAGGAGACAGCCAGAAGCAAGCTTTTGGAGCTGAAGGA
ACCTGAGACAGAAGCTAGTCCCCCCTCTGAATTTTACTGATGAAGAAACTGAGGCCACAG
AGCTAAAGTGACTTTTCCCAAGGTCGCCCAGCGAGGACGTGGGACTTCTCAGACGTCAGG
AGAGTGATGTGAGGGAGCTGTGTGACCATAGAAAGTGACGTGTTAAAAACCAGCGCTGCC
CTCTTTGAAAGCCAGGGAGCATCATTCATTTAGCCTGCTGAGAAGAAGAAACCAAGTGTC
CGGGATTCAGACCTCTCTGCGGCCCCAAGTGTTCGTGGTGCTTCCAGAGGCAGGGCTATG
CTCACATTCATGGCCTCTGACAGCGAGGAAGAAGTGTGTGATGAGCGGACGTCCCTAATG
TCGGCCGAGAGCCCCACGCCGCGCTCCTGCCAGGAGGGCAGGCAGGGCCCAGAGGATGGA
GAGAATACTGCCCAGTGGAGAAGCCAGGAGAACGAGGAGGACGGTGAGGAGGACCCTGAC
CGCTATGTCTGTAGTGGGGTTCCCGGGCGGCCGCCAGGCCTGGAGGAAGAGCTGACCCTC
AAATACGGAGCGAAGCATGTGATCATGCTGTTTGTGCCTGTCACTCTGTGCATGATCGTG
GTGGTAGCCACCATCAAGTCTGTGCGCTTCTACACAGAGAAGAATGGACAGCTCATCTAC
ACGCCATTCACTGAGGACACACCCTCGGTGGGCCAGCGCCTCCTCAACTCCGTGCTGAAC
ACCCTCATCATGATCAGCGTCATCGTGGTTATGACCATCTTCTTGGTGGTGCTCTACAAG
TACCGCTGCTACAAGTTCATCCATGGCTGGTTGATCATGTCTTCACTGATGCTGCTGTTC
CTCTTCACCTATATCTACCTTGGGGAAGTGCTCAAGACCTACAATGTGGCCATGGACTAC
CCCACCCTCTTGCTGACTGTCTGGAACTTCGGGGCAGTGGGCATGGTGTGCATCCACTGG
AAGGGCCCTCTGGTGCTGCAGCAGGCCTACCTCATCATGATCAGTGCGCTCATGGCCCTA
GTGTTCATCAAGTACCTCCCAGAGTGGTCCGCGTGGGTCATCCTGGGCGCCATCTCTGTG
TATGATCTCGTGGCTGTGCTGTGTCCCAAAGGGCCTCTGAGAATGCTGGTAGAAACTGCC
CAGGAGAGAAATGAGCCCATATTCCCTGCCCTGATATACTCATCTGCCATGGTGTGGACG
GTTGGCATGGCGAAGCTGGACCCCTCCTCTCAGGGTGCCCTCCAGCTCCCCTACGACCCG
GAGATGGAAGAAGACTCCTATGACAGTTTTGGGGAGCCTTCATACCCCGAAGTCTTTGAG
CCTCCCTTGACTGGCTACCCAGGGGAGGAGCTGGAGGAAGAGGAGGAAAGGGGCGTGAAG
CTTGGCCTCGGGGACTTCATCTTCTACAGTGTGCTGGTGGGCAAGGCGGCTGCCACGGGC
AGCGGGGACTGGAATACCACGCTGGCCTGCTTCGTGGCCATCCTCATTGGCTTGTGTCTG
ACCCTCCTGCTGCTTGCTGTGTTCAAGAAGGCGCTGCCCGCCCTCCCCATCTCCATCACG
TTCGGGCTCATCTTTTACTTCTCCACGGACAACCTGGTGCGGCCGTTCATGGACACCCTG
GCCTCCCATCAGCTCTACATCTGAGGGACATGGTGTGCCACAGGCTGCAAGCTGCAGGGA
ATTTTCATTGGATGCAGTTGTATAGTTTTACACTCTAGTGCCATATATTTTTAAGACTTT
TCTTTCCTTAAAAAATAAAGTACGTGTTTACTTGGTGAGGAGGAGGCAGAACCAGCTCTT
TGGTGCCAGCTGTTTCATCACCAGACTTTGGCTCCCGCTTTGGGGAGCGCCTCGCTTCAC
GGACAGGAAGCACAGCAGGTTTATCCAGATGAACTGAGAAGGTCAGATTAGGGTGGGGAG
AAGAGCATCCGGCATGAGGGCTGAGATGCGCAAAGAGTGTGCTCGGGAGTGGCCCCTGGC
ACCTGGGTGCTCTGGCTGGAGAGGAAAAGCCAGTTCCCTACGAGGAGTGTTCCCAATGCT
TTGTCCATGATGTCCTTGTTATTTTATTGCCTTTAGAAACTGAGTCCTGTTCTTGTTACG
GCAGTCACACTGCTGGGAAGTGGCTTAATAGTAATATCAATAAATAGATGAGTCCTGTTA
GAATCTTGAAAAAAAAAAAAAAAAAAA
>OriGene 5' read for NM_000447 unedited
NNNNGGGGGGNNNNNNNNCTCCCCNCNNNCGGTTCAAAATTGNATACGACTCATATAGGC
GGCCGCGAAATTCGCACGAGGCAGAGCAGGCATTTCCAGCAGTGAGGAGACAGCCAGAAG
CAAGCTTTTGGAGCTGAAGGAACCTGAGACAGAAGCTAGTCCCCCCTCTGAATTTTACTG
ATGAAGAAACTGAGGCCACAGAGCTAAAGTGACTTTTCCCAAGGTCGCCCAGCGAGGACG
TGGGACTTCTCAGACGTCAGGAGAGTGATGTGAGGGAGCTGTGTGACCATAGAAAGTGAC
GTGTTAAAAACCAGCGCTGCCCTCTTTGAAAGCCAGGGAGCATCATTCATTTAGCCTGCT
GAGAAGAAGAAACCAAGTGTCCGGGATTCAGACCTCTCTGCGGCCCCAAGTGTTCGTGGT
GCTTCCAGAGGCAGGGCTATGCTCACATTCATGGCCTCTGACAGCGAGGAAGAAGTGTGT
GATGAGCGGACGTCCCTAATGTCGGCCGAGAGCCCCACGCCGCGCTCCTGCCAGGAGGGC
AGGCAGGGCCCAGAGGATGGAGAGAATACTGCCCAGTGGAGAAGCCAGGAGAACGAGGAG
GACGGTGAGGAGGACCCTGACCGCTATGTCTGTAGTGGGGTTCCCGGGCGGNCGNCAGGC
CTGGAGGAAGAGCTGACCCTCANATACNGAGCGAAGCATGTGATCATGCNTGTTGTGCCT
GTCACTCTGTGCATGATCGTGGTGGTAGCCACCATCAAGTCTGTGCGCTTCTACACAGAG
AAGAATGGACAGCTCATCTACACGCCATTCACTTGAGACACACCCCTCGTGGGGCAGCGC
CTNCTCAACTNCGTGCTGAACACCCTCATCATGATCAGCGTCATCGTGGTTATGACCATC
TTCTGGGTGTGCTCTACAGTACCGTGCTACAAGTCATCATGGCTGGNTGACATGTCTCAC
TGAAGCTGCGGTCCTTT
>OriGene 3' read for NM_000447 unedited
TCCCGGCCAGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTCAGG
AAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTCAAGA
TTCTAACAGGACTCATCTATTTATTGATATTACTATTAAGCCACTTCCCAGCAGTGTGAC
TGCCGTAACAAGAACAGGACTCAGTTTCTAAAGGCAATAAAATAACAAGGACATCATGGA
CAAAGCATTGGGAACACTCCTCGTAGGGAACTGGCTTTTCCTCTCCAGCCAGAGCACCCA
GGTGCCAGGGGCCACTCCCGAGCACACTCTTTGCGCATCTCAGCCCTCATGCCGGATGCT
CTTCTCCCCACCCTAATCTGACCTTCTCAGTTCATCTGGATAAACCTGCTGTGCTTCCTG
TCCGTGAAGCGAGGCGCTCCCCAAAGCGGGAGCCAAAGTCTGGTGATGAAACAGCTGGCA
CCAAAGAGCTGGTTCTGCCTCCTCCTCACCAAGTAAACACGTACTTTATTTTTTAAGGAA
AGAAAAGTCTTAAAAATATATGGCACTAGAGTGTAAAACTATACAACTGCATCCAATGAA
AATTCCCTGCAGCTTGCAGCCTGTGGCACACCATGTCCCTCANATGTAGAGCTGATGGGA
GGCCAGGGTGTCCATGAACGGCCGCACCAGGTTGTCCGTGGAGAAGTAAAAGATGAGCCC
GAACGTGATGGANATGGNGAGGGCGGGCAGCCN
Restriction Sites NotI-NotI     
ACCN NM_000447
Insert Size 2250 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation The ORF of this clone has been fully sequenced and found to be a perfect match to NM_000447.2.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000447.1, NP_000438.1
RefSeq Size 2236 bp
RefSeq ORF 1347 bp
Locus ID 5664
Cytogenetics 1q42.13
Domains Presenilin, PSN
Protein Families Druggable Genome, Protease, Transmembrane
Protein Pathways Alzheimer's disease, Notch signaling pathway
Gene Summary 'Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (1) encodes the longer isoform (1).

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