Thrombomodulin (THBD) (NM_000361) Human Untagged Clone

CAT#: SC119928

THBD (untagged)-Human thrombomodulin (THBD)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: THBD
• Synonyms: AHUS6; BDCA3; CD141; THPH12; THRM; TM
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC119928 sequence for NM_000361 edited (data generated by NextGen Sequencing)
  ATGCTTGGGGTCCTGGTCCTTGGCGCGCTGGCCCTGGCCGGCCTGGGGTTCCCCGCACCC
  GCAGAGCCGCAGCCGGGTGGCAGCCAGTGCGTCGAGCACGACTGCTTCGCGCTCTACCCG
  GGCCCCGCGACCTTCCTCAATGCCAGTCAGATCTGCGACGGACTGCGGGGCCACCTAATG
  ACAGTGCGCTCCTCGGTGGCTGCCGATGTCATTTCCTTGCTACTGAACGGCGACGGCGGC
  GTTGGCCGCCGGCGCCTCTGGATCGGCCTGCAGCTGCCACCCGGCTGCGGCGACCCCAAG
  CGCCTCGGGCCCCTGCGCGGCTTCCAGTGGGTTACGGGAGACAACAACACCAGCTATAGC
  AGGTGGGCACGGCTCGACCTCAATGGGGCTCCCCTCTGCGGCCCGTTGTGCGTCGCTGTC
  TCCGCTGCTGAGGCCACTGTGCCCAGCGAGCCGATCTGGGAGGAGCAGCAGTGCGAAGTG
  AAGGCCGATGGCTTCCTCTGCGAGTTCCACTTCCCAGCCACCTGCAGGCCACTGGCTGTG
  GAGCCCGGCGCCGCGGCTGCCGCCGTCTCGATCACCTACGGCACCCCGTTCGCGGCCCGC
  GGAGCGGACTTCCAGGCGCTGCCGGTGGGCAGCTCCGCCGCGGTGGCTCCCCTCGGCTTA
  CAGCTAATGTGCACCGCGCCGCCCGGAGCGGTCCAGGGGCACTGGGCCAGGGAGGCGCCG
  GGCGCTTGGGACTGCAGCGTGGAGAACGGCGGCTGCGAGCACGCGTGCAATGCGATCCCT
  GGGGCTCCCCGCTGCCAGTGCCCAGCCGGCGCCGCCCTGCAGGCAGACGGGCGCTCCTGC
  ACCGCATCCGCGACGCAGTCCTGCAACGACCTCTGCGAGCACTTCTGCGTTCCCAACCCC
  GACCAGCCGGGCTCCTACTCGTGCATGTGCGAGACCGGCTACCGGCTGGCGGCCGACCAA
  CACCGGTGCGAGGACGTGGATGACTGCATACTGGAGCCCAGTCCGTGTCCGCAGCGCTGT
  GTCAACACACAGGGTGGCTTCGAGTGCCACTGCTACCCTAACTACGACCTGGTGGACGGC
  GAGTGTGTGGAGCCCGTGGACCCGTGCTTCAGAGCCAACTGCGAGTACCAGTGCCAGCCC
  CTGAACCAAACTAGCTACCTCTGCGTCTGCGCCGAGGGCTTCGCGCCCATTCCCCACGAG
  CCGCACAGGTGCCAGATGTTTTGCAACCAGACTGCCTGTCCAGCCGACTGCGACCCCAAC
  ACCCAGGCTAGCTGTGAGTGCCCTGAAGGCTACATCCTGGACGACGGTTTCATCTGCACG
  GACATCGACGAGTGCGAAAACGGCGGCTTCTGCTCCGGGGTGTGCCACAACCTCCCCGGT
  ACCTTCGAGTGCATCTGCGGGCCCGACTCGGCCCTTGCCCGCCACATTGGCACCGACTGT
  GACTCCGGCAAGGTGGACGGTGGCGACAGCGGCTCTGGCGAGCCCCCGCCCAGCCCGACG
  CCCGGCTCCACCTTGACTCCTCCGGCCGTGGGGCTCGTGCATTTGGGCTTGCTCATAGGC
  ATCTCCATCGCGAGCCTGTGCCTGGTGGTGGCGCTTTTGGCGCTCCTCTGCCACCTGCGC
  AAGAAGCAGGGCGCCGCCAGGGCCAAGATGGAGTACAAGTGCGCGGCCCCTTCCAAGGAG
  GTAGTGCTGCAGCACGTGCGGACCGAGCGGACGCCGCAGAGACTCTGA
  
  Clone variation with respect to NM_000361.2
  1544 c=>t
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000361 unedited
  CCCCGTCAGAATTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGCGCAGGGC
  TGCGCGCAGCGGCAAGAATGTCTGGGCTGGGACGGACAGGAGAGGCTGTCGCCATCGGCG
  TCCTGTGCCCCTCTGCTCCGGCACGGCCCTGTCGCAGTGCCCGCGCTTTCCCCGGCGCCT
  GCACGCGGCGCGCCTGGGTAACATGCTTGGGGTCCTGGTCCTTGGCGCGCTGGCCCTGGC
  CGGCCTGGGGTTCCCCGCACCCGCAGAGCCGCAGCCGGGTGGCAGCCAGTGCGTCGAGCA
  CGACTGCTTCGCGCTCTACCCGGGCCCCGCGACCTTCCTCAATGCCAGTCAGATCTGCGA
  CGGACTGCGGGGCCACCTAATGACAGTGCGCTCCTCGGTGGCTGCCGATGTCATTTCCTT
  GCTACTGAACGGCGACGGCGGCGTTGGCCGCCGGCGCCTCTGGATCGGCCTGCAGCTGCC
  ACCCGGCTGCGGCGACCCCAAGCGCCTCGGGCCCCTGCGCGGCTTCCAGTGGGTTACGGG
  AGACAACAACACCAGCTATAGCAGGTGGGCACGGCTCGACCTCAATGGGGCTCCCCTCTG
  CGGCCCGTTGTGCGTCGCTGTCTCCGCTGCTGAGGCCACTGTGCCCAGCGAGCCGATCTG
  GGAGGAGCAGCAGTGCGAAGTGAAGGCCGATGGCTTCCTCTGCGAGTTCCACTTCCCAGC
  CACCTGCAGGCCACTGGCTGTGGAGCCCGGCGCCGCGGCTGCCGCCGTCTCGATCACCTA
  CGGCACCCCGTTCGCGGCCCGGGGAGCGGACTTCCAGCGCTGCCGATGGGCACTCCGNCC
  GCGTGGCTCCCCTCGGCTACAGCTAATGTGCACCGCGCGCCCC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000361 unedited
  CCATAGTTGCCCGCGGCCGCATCCTACGAGCGAGGTTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTTTTTCCCATGGTTATTGGTTAATTTTGCCCAAGGGAGGCCATAAGCAGG
  GAATTTTGCCTGGGTTTTAAATTATTTCCAATAAATAAATAACTATGTCCAAATATTTTG
  GGTTTACAAAATAAAAGAGGAAACCTTTTGTTTTACAAAGGTTACTTTTTTAGGACACAT
  TTATTTCCATACCCTGAAGCAGGATTTCATTCTTAGTTTAGTTGACCCAAAGACTTTGCA
  AACCTTGTGGGGCAGGGTCTAAAGTTGGGTCCCTAGCTTTTTTTACCAAGGAGCAAGGTT
  CCCCAAAGAAAATTCTTCATTTTTTTGAAAATAGGGGCCTGACTTGCCCTGTTACTTATA
  ACTGATCTATATTTCATGTATTCCAAAAAATTGGAACCAGTTTGAAAGGGTTGCCCTCAA
  ATTACTGAGCAAACACACCCCTTGCAAATTTTGTTAAATATAAATTCTCATGAACTGGAT
  GGGGGGGACCCTAGGATTTTGCTTTTTTAACCAGCTCCCATGGGCGGGGCAGTTTCCAAT
  TTTTGTTCAGGGGCCACATTCCAAAGGGCTTCTTTGAAGGGGTAAAAATTCTCTGAGGAC
  CTGATTAAGGTTAGGCCCTAATTGGGCATCTTCCAGGATCCTTTCCCAAGCTCCCAATTC
  CACAAGACCAGGAGAGCTGGTTTTATTTTGGTCTACCAGGGACAAGGAACAGTGCCCGTC
  CAATTGTTAATGGCATGAATCATGCCATTTGAAGCTTTTTTGAACTGTTTCTTGGGAGGG
  GTTTGGCTTTTTTTTAAATTTAGAGCACCTTTTTGAACATTTTTAACCCTTGTCAAACAA
  TAGTTATAATAACCAAGAGGGCAAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_000361
• Insert Size: 4200 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000361.2, NP_000352.1
• RefSeq Size: 4048 bp
• RefSeq ORF: 1728 bp
• Locus ID: 7056
• Cytogenetics: 20p11.21
• Domains: CLECT, EGF
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Complement and coagulation cascades
• Gene Summary: 'The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]'