Prealbumin (TTR) (NM_000371) Human Untagged Clone

CAT#: SC119937

TTR (untagged)-Human transthyretin (TTR)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TTR
• Synonyms: ATTR; CTS; CTS1; HEL111; HsT2651; PALB; TBPA
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC119937 sequence for NM_000371 edited (data generated by NextGen Sequencing)
  ATGGCTTCTCATCGTCTGCTCCTCCTCTGCCTTGCTGGACTGGTATTTGTGTCTGAGGCT
  GGCCCTACGGGCACCGGTGAATCCAAGTGTCCTCTGATGGTCAAAGTTCTAGATGCTGTC
  CGAGGCAGTCCTGCCATCAATGTGGCCGTGCATGTGTTCAGAAAGGCTGCTGATGACACC
  TGGGAGCCATTTGCCTCTGGGAAAACCAGTGAGTCTGGAGAGCTGCATGGGCTCACAACT
  GAGGAGGAATTTGTAGAAGGGATATACAAAGTGGAAATAGACACCAAATCTTACTGGAAG
  GCACTTGGCATCTCCCCATTCCATGAGCATGCAGAGGTGGTATTCACAGCCAACGACTCC
  GGCCCCCGCCGCTACACCATTGCCGCCCTGCTGAGCCCCTACTCCTATTCCACCACGGCT
  GTCGTCACCAATCCCAAGGAATGA
  
  Clone variation with respect to NM_000371.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000371 unedited
  CACGAGGGCAGGATGGCTTCTCATCGTCTGCTCCTCCTCTGCCTTGCTGGACTGGTATTT
  GTGTCTGAGGCTGGCCCTACGGGCACCGGTGAATCCAAGTGTCCTCTGATGGTCAAAGTT
  CTAGATGCTGTCCGAGGCAGTCCTGCCATCAATGTGGCCGTGCATGTGTTCAGAAAGGCT
  GCTGATGACACCTGGGAGCCATTTGCCTCTGGGAAAACCAGTGAGTCTGGAGAGCTGCAT
  GGGCTCACAACTGAGGAGGAATTTGTAGAAGGGATATACAAAGTGGAAATAGACACCAAA
  TCTTACTGGAAGGCACTTGGCATCTCCCCATTCCATGAGCATGCAGAGGTGGTATTCACA
  GCCAACGACTCCGGCCCCCGCCGCTACACCATTGCCGCCCTGCTGAGCCCCTACTCCTAT
  TCCACCACGGCTGTCGTCACCAATCCCAAGGAATGAGGGACTTCTCCTCCAGTGGACCTG
  AAGGACGAGGGATGGGATTTCATGTAACCAAGAGTATTCCATTTTTACTAAAGCAGTGTT
  TTCACCTCATATGCTATGTTAGAAGTCCAGGCAGAGACAATAAAACATTCCTGTGAAAGG
  CAAAAAAAAAAAAAAAAAACTCGACTCTAGATTGCGGCCGCGGTCATAGCTGTTTCCTGA
  ACAGATCCCGGGTGGCATCCCTGTGACCCCTCCCCAGTGCCTCTCCTGGCCCTGGAAGTT
  GCCACTCCAGTGCCCACCAGCCTTGTCCTAATAAAATTAAGTTGCATCATT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000371 unedited
  GCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGCCTTTCACAGGATGTTTTATTGTCT
  CTGCCTGGACTTCTAACATAGCATATGAGGTGAAAACACTGCTTTAGTAAAAATGGAATA
  CTCTTGGTTACATGAAATCCCATCCCTCGTCCTTCAGGTCCACTGGAGGAGAAGTCCCTC
  ATTCCTTGGGATTGGTGACGACAGCCGTGGTGGAATAGGAGTAGGGGCTCAGCAGGGCGG
  CAATGGTGTATCGGCGGGGGCCGGAGTCGTTGGCTGTGAATACCACCTCTGCATGCTCAT
  GGAATGGGGAGATGCCAAGTGCCTTCCAGTAAGATTTGGTGTCTATTTCCACTTTGTATA
  TCCCTTCTACAAATTCCTCCTCAGTTGTGAGCCCATGCAGCTCTCCAGACTCACTGGTTT
  TCCCAGAGGCAAATGGCTCCCAGGTGTCATCAGCAGCCTTTCTGAACACATGCACGGCCA
  CATTGATGGCAGGACTGCCTCGGACAGCATCTAGAACTTTGACCATCAGAGGACACTTGG
  ATTCACCGGTGCCCGTATGGCCAGCCTCAGACACAAATACCAGTCCAGCAAGGCAGATGA
  GGAGCAGACGATGAGAAGCCATCCTGCCCTCGTGCCGAATTCGCGGCCGCCCTATAGTGA
  GTCGTATTACAAAATTCTGACGGTTCACTAAACGAGCTCTGCTTATATAGACCTNCCACC
  GTACACGCCTACCGCCCATTTTGCGTCACGGGGCGGGGTTATTACGACATTTTGGAAAGT
  CCCCGTGATTTTGGTGCCAACCAACTCCCATGACGTCATGGGGTGAGACTTGGAATCCCG
  CGAGTCAACCGCTATCACGCCATTGTTGACGCCAAACCGCTCACATGGNATAGCGAGACT
  ATACCTAAAGTACTGCAGTAGAAGTCCCGTAGTCATGACTGGCTAATGCAGCGGCCTTTA
  CGTCTGAGTAATAGGGCGACTCGCTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_000371
• Insert Size: 630 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000371.1, NP_000362.1
• RefSeq Size: 615 bp
• RefSeq ORF: 444 bp
• Locus ID: 7276
• Cytogenetics: 18q12.1
• Domains: TR_THY
• Protein Families: ES Cell Differentiation/IPS, Secreted Protein
• Gene Summary: 'This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017]'