GLDC (NM_000170) Human Untagged Clone

CAT#: SC120090

GLDC (untagged)-Human glycine dehydrogenase (decarboxylating) (GLDC), nuclear gene encoding mitochondrial protein


  "NM_000170" in other vectors (6)

Reconstitution Protocol

USD 1,100.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol GLDC
Synonyms GCE; GCSP; HYGN1
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_000170 edited
GGCACGAGGGCAGCGCCCATTCATTGCCCGCGAGCGTCCATCCATCTGTCCGGCCGACTG
TCCAGCGAAAGGGGCTCCAGGCCGGGCGCAGCCGCCACCCGGGGGACCGAGGCCAGGAGA
GGGGCCAAGAGCGCGGCTGACCCTTGCGGGCCGGGGCAGGGGACGGTGGCCGCGGCCATG
CAGTCCTGTGCCAGGGCGTGGGGGCTGCGCCTGGGCCGCGGGGTCGGGGGCGGCCGCCGC
CTGGCTGGGGGATCGGGGCCGTGCTGGGCGCCGCGGAGCCGGGACAGCAGCAGTGGCGGC
GGGGACAGCGCCGCGGCTGGGGCCTCGCGCCTCCTGGAGCGCCTTCTGCCCAGACACGAC
GACTTCGCTCGGAGGCACATCGGCCCTGGGGACAAAGACCAGAGAGAGATGCTGCAGACC
TTGGGGCTGGCGAGCATTGATGAATTGATCGAGAAGACGGTCCCTGCCAACATCCGTTTG
AAAAGACCCTTGAAAATGGAAGACCCTGTTTGTGAAAATGAAATCCTTGCAACTCTGCAT
GCCATTTCAAGCAAAAACCAGATCTGGAGATCGTATATTGGCATGGGCTATTATAACTGC
TCAGTGCCACAGACGATTTTGCGGAACTTACTGGAGAACTCAGGATGGATCACCCAGTAT
ACTCCATACCAGCCTGAGGTGTCTCAGGGGAGGCTGGAGAGTTTACTCAACTACCAGACC
ATGGTGTGTGACATCACAGGCCTGGACATGGCCAATGCATCCCTGCTGGATGAGGGGACT
GCAGCCGCAGAGGCACTGCAGCTGTGCTACAGACACAACAAGAGGAGGAAATTTCTCGTT
GATCCCCGTTGCCACCCACAGACAATAGCTGTTGTCCAGACTCGAGCCAAATATACTGGA
GTCCTCACTGAGCTGAAGTTACCCTGTGAAATGGACTTCAGTGGAAAAGATGTCAGTGGA
GTGTTGTTCCAGTACCCAGACACGGAGGGGAAGGTGGAAGACTTTACGGAACTCGTGGAG
AGAGCTCATCAGAGTGGGAGCCTGGCCTGCTGTGCTACTGACCTTTTAGCTTTGTGCATC
TTGAGGCCACCTGGAGAATTTGGGGTAGACATCGCCCTGGGCAGCTCCCAGAGATTTGGA
GTGCCACTGGGCTATGGGGGACCCCATGCAGCATTTTTTGCTGTCCGAGAAAGCTTGGTG
AGAATGATGCCTGGAAGAATGGTGGGGGTAACAAGAGATGCCACTGGGAAAGAAGTGTAT
CGTCTTGCTCTTCAAACCAGGGAGCAACACATTCGGAGAGACAAGGCTACCAGCAACATC
TGTACAGCTCAGGCCCTCTTGGCGAATATGGCTGCCATGTTTGCAATCTACCATGGTTCC
CATGGGCTGGAGCATATTGCTAGGAGGGTACATAATGCCACTTTGATTTTGTCAGAAGGT
CTCAAGCGAGCAGGGCATCAACTCCAGCATGACCTGTTCTTTGATACCTTGAAGATTCAG
TGTGGCTGCTCAGTGAAGGAGGTCTTGGGCAGGGCCGCTCAGCGGCAGATCAATTTTCGG
CTTTTTGAGGATGGCACACTTGGTATTTCTCTTGATGAAACAGTCAATGAAAAAGATCTG
GACGATTTGTTGTGGATCTTTGGTTGTGAGTCATCTGCAGAACTGGTTGCTGAAAGCATG
GGAGAGGAGTGCAGAGGTATTCCAGGGTCTGTGTTCAAGAGGACCAGCCCGTTCCTCACC
CATCAAGTGTTCAACAGCTACCACTCTGAAACAAACATTGTCCGGTACATGAAGAAACTG
GAAAATAAAGACATTTCCCTTGTTCACAGCATGATTCCACTGGGATCCTGCACCATGAAA
CTGAACAGTTCGTCTGAACTCGCACCTATCACATGGAAAGAATTTGCAAACATCCACCCC
TTTGTGCCTCTGGATCAAGCTCAAGGATATCAGCAGCTTTTCCGAGAGCTTGAGAAGGAT
TTGTGTGAACTCACAGGTTATGACCAGGTCTGTTTCCAGCCAAACAGCGGAGCCCAGGGA
GAATATGCTGGACTGGCCACTATCCGAGCCTACTTAAACCAGAAAGGAGAGGGGCACAGA
ACGGTTTGCCTCATTCCGAAATCAGCACATGGGACCAACCCAGCAAGTGCCCACATGGCA
GGCATGAAGATTCAGCCTGTGGAGGTGGATAAATATGGGAATATCGATGCAGTTCACCTC
AAGGCCATGGTGGATAAGCACAAGGAGAACCTAGCAGCTATCATGATTACATACCCATCC
ACCAATGGGGTGTTTGAAGAGAACATCAGTGACGTGTGTGACCTCATCCATCAACATGGA
GGACAGGTCTACCTAGACGGGGCAAATATGAATGCTCAGGTGGGAATCTGTCGCCCTGGA
GACTTCGGGTCTGATGTCTCGCACCTAAATCTTCACAAGACCTTCTGCATTCCCCACGGA
GGAGGTGGTCCTGGCATGGGGCCCATCGGAGTGAAGAAACATCTCGCCCCGTTTTTGCCC
AATCATCCCGTCATTTCACTAAAGCGGAATGAGGATGCCTGTCCTGTGGGAACCGTCAGT
GCGGCCCCATGGGGCTCCAGTTCCATCTTGCCCATTTCCTGGGCTTATATCAAGATGATG
GGAGGCAAGGGTCTTAAACAAGCCACGGAAACTGCGATATTAAATGCCAACTACATGGCC
AAGCGATTAGAAACACACTACAGAATTCTTTTCAGGGGTGCAAGAGGTTATGTGGGTCAT
GAATTTATTTTGGACACGAGACCCTTCAAAAAGTCTGCAAATATTGAGGCTGTGGATGTG
GCCAAGAGACTCCAGGATTATGGATTTCACGCCCCTACCATGTCCTGGCCTGTGGCAGGG
ACCCTCATGGTGGAGCCCACTGAGTCGGAGGACAAGGCAGAGCTGGACAGATTCTGTGAT
GCCATGATCAGCATTCGGCAGGAAATTGCTGACATTGAGGAGGGCCGCATCGACCCCAGG
GTCAATCCGCTGAAGATGTCTCCACACTCCCTGACCTGCGTTACATCTTCCCACTGGGAC
CGGCCTTATTCCAGAGAGGTGGCAGCATTCCCACTCCCCTTCGTGAAACCAGAGAACAAA
TTCTGGCCAACGATTGCCCGGATTGATGACATATATGGAGATCAGCACCTGGTTTGTACC
TGCCCACCCATGGAAGTTTATGAGTCTCCATTTTCTGAACAAAAGAGGGCGTCTTCTTAG
TCCTCTCTCCCTAAGTTTAAAGGACTGATTTGATGCCTCTCCCCAGAGCATTTGATAAGC
AAGAAAGATTTCATCTCCCACCCCAGCCTCAAGTAGGAGTTTTATATACTGTGTATATCT
CTGTAATCTCTGTCAAGGTAAATGTAAATACAGTAGCTGGAGGGAGTCGAAGCTGATGGT
TGGAAGACGGATTTGCTTTGGTATTCTGCTTCCACATGTGCCAGTTGCCTGGATTGGGAG
CCATTTTGTGTTTTGCGTAGAAAGTTTTAGGAACTTTAACTTTTAATGTGGCAAGTTTGC
AGATGTCATAGAGGCTATCCTGGAGACTTAATAGACATTTTTTTGTTCCAAAAGAGTCCA
TGTGGACTGTGCCATCTGTGGGAAATCCCAGGGCAAATGTTTACATTTTGTATACCCTGA
AGAACTCTTTTTCCTCTAATATGCCTAATCTGTAATCACATTTCTGAGTGTTTTCCTCTT
TTTCTGTGTGAGGTTTTTTTTTTTTAATCTGCATTTATTAGTATTCTAATAAAAGCTTTT
GATCGGAAAAAAAAAAAAAAAAAAC
>OriGene 5' read for NM_000170 unedited
GGTCACAATTGTATACGACTCACTATAGGCGGCCGCGATTCGGCACGAGGGCAGCGCCCA
TTCATTGCCCGCGAGCGTCCATCCATCTGTCCGGCCGACTGTCCAGCGAAAGGGGCTCCA
GGCCGGGCGCAGCCGCCACCCGGGGGACCGAGGCCAGGAGAGGGGCCAAGAGCGCGGCTG
ACCCTTGCGGGCCGGGGCAGGGGACGGTGGCCGCGGCCATGCAGTCCTGTGCCAGGGCGT
GGGGGCTGCGCCTGGGCCGCGGGGTCGGGGGCGGCCGCCGCCTGGCTGGGGGATCGGGGC
CGTGCTGGGCGCCGCGGAGCCGGGACAGCAGCAGTGGCGGCGGGGACAGCGCCGCGGCCT
GGGGGCCTCGCGCCTCCTGGAGCGCCTTCTGCCCAGACACGACGACTTCGCTCGGAGGCA
CATCGGCCCTGGGGACAAAGACCAGAGAGAGATGCTGCAGACCTTGGGGCTGGCGAGCAT
TGATGAATTGATCGAGAAGACGGTCCCTGCCAACATCCGTTTGAAAAGACCCTTGAAAAT
GGAAGACCCTGTTTGTGAAAATGAAATCCTTGCAACTCTGCATGCCATTTCAAGCAAAAA
CCAGATCTGGAGATCGTATATTGGCATGGGCTATTAATCGGGGGTTCAATGCCACAGACG
ATTTTGCGGAACTTACTGGAGAACTCANGATGGATCACCCAGTATACTCCATTACCAGCC
TGAGTGTCTCAGGNGAGGCTGNGAGAGTTACTCAACTACCAGACCATGGGTGTGTGACAT
CACAGGCCTGGACATGGCCAATGCATCCCTGCTGGATGAAGGGGACTGCAGCCGCANAAG
CACTGCAGCTGTGCTACAGACACAACAAGAGGGAGGAAATTTCTCGTTGATCCCCGTTGC
CACCACAGACAATACCTGTTGTTCAGACTCGAGCCAAATTC
>OriGene 3' read for NM_000170 unedited
TATGGACCGCGGCACGCAATCTAGTATCGAGTTTTTTTTTTTTTTTTTTCCGATCAAAAG
CTTTTATTAGAATACTAATAAATGCAGATTAAAAAAAAAAAACCTCACACAGAAAAAGAG
GAAAACACTCAGAAATGTGATTACAGATTAGGCATATTAGAGGAAAAAGAGTTCTTCAGG
GTATACAAAATGTAAACATTTGCCCTGGGATTTCCCACAGATGGCACAGTCCACATGGAC
TCTTTTGGAACAAAAAAATGTCTATTAAGTCTCCAGGATAGCCTCTATGACATCTGCAAA
CTTGCCACATTAAAAGTTAAAGTTCCTAAAACTTTCTACGCAAAACACAAAATGGCTCCC
AATCCAGGCAACTGGCACATGTGGAAGCAGAATACCAAAGCAAATCCGTCTTCCAACCAT
CNAGCTTCGACTTCCTTCCCACCTACTGGAATTTAACCTTTTAACCCTTGGGGCGGGGTT
TTTCCCCGGGTATTTTCCCCCGGGTTTTTTAAAACCCCCCTTTTGGGGGGGGGGGGGGGG
AAAAAAAATTTTTTTGGTCTTAAAAGCGCCCGGGGGGGAGGGGGCAAAAAAACCCCCTCT
TTTAACCTGTTTGGGGGGGAGGGAGGGCCCTTTAAAAAACCCCCCCCCTTTTTTTTTTTT
TAAAAAAAAGGGGGGGGGCTCTCTTCCTTCCCTCCCCCCCGGGGGGGGGGGGGGGGGGGA
AAAAAAAAAAGGGGGGGGGGGCCCTCTTTTATTTTTTAAAACTTCCGGCGGGCCTGTGGG
GGGCCAAAAAAATATTTTTTTTTTTTTTTTTCTTGGGGGGGGGGGGGGGGGGGCCCCCCC
CCCCTCTTTATAAATAAACCCCCCCCCCCCCAAAAAAA
Restriction Sites NotI-NotI     
ACCN NM_000170
Insert Size 3700 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000170.1, NP_000161.1
RefSeq Size 3783 bp
RefSeq ORF 3063 bp
Locus ID 2731
Cytogenetics 9p24.1
Domains GDC-P
Protein Families Druggable Genome
Protein Pathways Glycine, serine and threonine metabolism, Metabolic pathways
Gene Summary 'Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]'

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