p15 INK4b (CDKN2B) (NM_078487) Human Untagged Clone

CAT#: SC120261

CDKN2B (untagged)-Human cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 2


  "NM_078487" in other vectors (4)

Reconstitution Protocol

USD 420.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CDKN2B
Synonyms CDK4I; INK4B; MTS2; P15; p15INK4b; TP15
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_078487, the custom clone sequence may differ by one or more nucleotides


ATGCGCGAGGAGAACAAGGGCATGCCCAGTGGGGGCGGCAGCGATGAGGGTCTGGCCAGCGCCGCGGCGC
GGGGACTAGTGGAGAAGGTGCGACAGCTCCTGGAAGCCGGCGCGGATCCCAACGGAGTCAACCGTTTCGG
GAGGCGCGCGATCCAGGTAGCTGGGGCCCCAGGGCCTCGCCGGCAGGGGGCGCGCGAACGCGGGGCGCGG
CCTCGGCGGATCGGGGCTGGAACCTAG


>OriGene 5' read for NM_078487 unedited
CAAATTTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACCAGGCCGGCTGGCTCC
CCACTCTGCCAGAGCGAGGCGGGGCAGTGAGGACTCCGCGACGCGTCCGCACCCTGCGGC
CAGAGCGGCTTTGAGCTCGGCTGCGTCCGCGCTAGGCGCTTTTTCCCAGAAGCAATCCAG
GCGCGCCCGCTGGTTCTTGAGCGCCAGGAAAAGCCCGGAGCTAACGACCGGCCGCTCGGC
CACTGCACGGGGCCCCAAGCCGCAGAAGGACGACGGGAGGGTAATGAAGCTGAGCCCAGG
TCTCCTAGGAAGGAGAGAGTGCGCCGGAGCAGCGTGGGAAAGAAGGGAAGAGTGTCGTTA
AGTTTACGGCCAACGGTGGATTATCCGGGCCGCTGCGCGTCTGGGGGCTGCGGAATGCGC
GAGGAGAACAAGGGCATGCCCAGTGGGGGCGGCAGCGATGAGGGTCTGGCCAGCGCCGCG
GCGCGGGGACTAGTGGAGAAGGTGCGACAGCTCCTGGAAGCCGGCGCGGATCCCAACGGA
GTCAACCGTTTCGGGAGGCGCGCGATCCAGGTCATGATGATGGGCAGCGCCCGCGTGGCG
GAGCTGCTGCTGCTCCACGGCGCGGAGCCCAACTGCGCAGACCCTGCCACTCTCACCCGA
CCGGTGCATGATGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCGGGCC
GGGGCGCGGCTGGACGTGCGCGATGCCTGGGGTCGTCTGCCCGTGGACTTGGCCGAGGAG
CGGGGCCACCGCGACCTTGCAGGTTACCTGCGCCAGCCACGGGGGACTGACGCCAAGTTT
CCAAGCGCCACACGACTTTATTTTTTACCCATTTCCACCCCCACCACTTATTCATGAGGC
TGCCACCGGGAGCGGCGGAAGCCTGTAGACTGCAACCTGTTTGGACTACAGAAGGGAGAG
CGCCA
>OriGene 3' read for NM_078487 unedited
AATACTGTAGTANCGCGGCCGCAATCGAGGGATCCGTTTTTTTTCTTTTTTTTTTTTTAA
TGTTATTTTATTTATAAATTTATTTAACTTGCCCGATCTCTTGGAATAAATGTCAGGTAG
TAGAATTTGTACAAACCTTGGTAATGTCTTAGGTTTAGATACGAACTTAACAGGTATATT
TAATTTTCTGTATTCCACAATGGAGCTAGAAGCAGGACTCATGAAAATAGTAACTATATG
TTTTGCAGGTATCCTTCAAAGTGAAATCCTTAACAAATTTAACAGTATATATTAGGCTGC
TGATGAAACAGCTAAACCTGTCTGCCAGGTGGCTTCGAAAATGGAATTAATTTTTACATG
GCATTGATAAGTTACTATTTCAATGCCACCGACTGGTGATTGATACCCAATAATGTTTGA
GGTTTGCTTTACGGAAGAGAAACTGACAAAACAATCACAAAGAAATGTAATGTAGTACTG
GGGGATCCAGAAAACATATTCTTTAGATTACCCGAAAAACAAGTGCCGTTAAGAAGAGTT
CCAACATTTAATTAACACAAAAATAATGACATGTTCCAATATAGTTGATGGGAAAACATT
CATGGCCCGGTTAGAGCGGACGGCACAGGAGGGGAACGGCCCGGCGCGGAAAAGCATACA
CAATCAAGGAGGATATATAAACGTGGAACCTATTTGACAGTAGCAACGAATTAATTTTAT
CACGATGGTCCCGCATGGTGCGAGGTACGGGGAGGCTGAATAGGGATGCTTGCGTGGTCA
GGTACGGCGAGAGTGAAAGAATCGGCCCCCATGCTCTCCTGCTAATGCGCCAACGGTCGC
GGGTATTTTGCCGCTTGAGCGTCTATCCATTGAGGGTCGCGCACCCGCCCGACGGCGACC
ACTCCGCGCCGGGCCGT
Restriction Sites NotI-NotI     
ACCN NM_078487
Insert Size 3890 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_078487.2, NP_511042.1
RefSeq Size 4001 bp
RefSeq ORF 237 bp
Locus ID 1030
Cytogenetics 9p21.3
Protein Families Druggable Genome
Protein Pathways Cell cycle, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway
Gene Summary 'This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (2) uses a different splice site, which leads to a translation frame shift, when compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus when compared to isoform 1.

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