SIRP alpha (SIRPA) (NM_080792) Human Untagged Clone

CAT#: SC120326

SIRPA (untagged)-Human signal-regulatory protein alpha (SIRPA), transcript variant 3


  "NM_080792" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol SIRPA
Synonyms BIT; CD172A; MFR; MYD-1; P84; PTPNS1; SHPS1; SIRP
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_080792 edited
GAATTCGGCACGAGGCCCTGGCTTTATTTCTCGCGCGCTTGGGGTCTCTCCCAGTCTCCG
TCTCTCCATTTCTCCTGGGGGGCGGGGAGGGGGGGTCTCCAAAAACCGCGGCGGCGGCGG
CGGCCGCTCCAGGCGCCCGTTCCGGAGTCGGGGGGAGGCCCAGCCGGGAGGGGGGAAGGG
GGGGAGCCTTAGTCATTTCCCCGCTCCAGCCTGCTCCCGCCCGAGCGCGCACTCACGGCC
GCTCTCCCTCCTCGCTCCGCAGCCGCGGCCCATGGAGCCCGCCGGCCCGGCCCCCGGCCG
CCTCGGGCCGCTGCTCTGCCTGCTGCTCGCCGCGTCCTGCGCCTGGTCAGGAGTGGCGGG
TGAGGAGGAGCTGCAGGTGATTCAGCCTGACAAGTCCGTGTTGGTTGCAGCTGGAGAGAC
AGCCACTCTGCGCTGCACTGCGACCTCTCTGATCCCTGTGGGGCCCATCCAGTGGTTCAG
AGGAGCTGGACCAGGCCGGGAATTAATCTACAATCAAAAAGAAGGCCACTTCCCCCGGGT
AACAACTGTTTCAGACCTCACAAAGAGAAACAACATGGACTTTTCCATCCGCATCGGTAA
CATCACCCCAGCAGATGCCGGCACCTACTACTGTGTGAAGTTCCGGAAAGGGAGCCCCGA
TGACGTGGAGTTTAAGTCTGGAGCAGGCACTGAGCTGTCTGTGCGCGCCAAACCCTCTGC
CCCCGTGGTATCGGGCCCTGCGGCGAGGGCCACACCTCAGCACACAGTGAGCTTCACCTG
CGAGTCCCACGGCTTCTCACCCAGAGACATCACCCTGAAATGGTTCAAAAATGGGAATGA
GCTCTCAGACTTCCAGACCAACGTGGACCCCGTAGGAGAGAGCGTGTCCTACAGCATCCA
CAGCACAGCCAAGGTGGTGCTGACCCGCGAGGACGTTCACTCTCAAGTCATCTGCGAGGT
GGCCCACGTCACCTTGCAGGGGGACCCTCTTCGTGGGACTGCCAACTTGTCTGAGACCAT
CCGAGTTCCACCCACCTTGGAGGTTACTCAACAGCCCGTGAGGGCAGAGAACCAGGTGAA
TGTCACCTGCCAGGTGAGGAAGTTCTACCCCCAGAGACTACAGCTGACCTGGTTGGAGAA
TGGAAACGTGTCCCGGACAGAAACGGCCTCAACCGTTACAGAGAACAAGGATGGTACCTA
CAACTGGATGAGCTGGCTCCTGGTGAATGTATCTGCCCACAGGGATGATGTGAAGCTCAC
CTGCCAGGTGGAGCATGACGGGCAGCCAGCGGTCAGCAAAAGCCATGACCTGAAGGTCTC
AGCCCACCCGAAGGAGCAGGGCTCAAATACCGCCGCTGAGAACACTGGATCTAATGAACG
GAACATCTATATTGTGGTGGGTGTGGTGTGCACCTTGCTGGTGGCCCTACTGATGGCGGC
CCTCTACCTCGTCCGAATCAGACAGAAGAAAGCCCAGGGCTCCACTTCTTCTACAAGGTT
GCATGAGCCCGAGAAGAATGCCAGAGAAATAACACAGGACACAAATGATATCACATATGC
AGACCTGAACCTGCCCAAGGGGAAGAAGCCTGCTCCCCAGGCTGCGGAGCCCAACAACCA
CACGGAGTATGCCAGCATTCAGACCAGCCCGCAGCCCGCGTCGGAGGACACCCTCACCTA
TGCTGACCTGGACATGGTCCACCTCAACCGGACCCCCAAGCAGCCGGCCCCCAAGCCTGA
GCCGTCCTTCTCAGAGTACGCCAGCGTCCAGGTCCCGAGGAAGTGAATGGGACCGTGGTT
TGCTCTAGCACCCATCTCTACGCGCTTTCTTGTCCCACAGGGAGCCGCCGTGATGAGCAC
AGCCAACCCAGTTCCCGGAGGGCTGGGGCGGTGCAGGCTCTGGGACCCAGGGGCCAGGGT
GGCTCTTCTCTCCCCACCCCTCCTTGGCTCTCCAGCACTTCCTGGGCAGCCACGGCCCCC
TCCCCCCACATTGCCACATACCTGGAGGCTGACGTTGCCAAACCAGCCAGGGAACCAACC
TGGGAAGTGGCCAGAACTTCCTGGGGTCCAAGAACTCTTGTGCCTCCGTCCATCACCATG
TGGGTTTTGAAGACCCTCGACTGCCTCCCCGATGCTCCGAAGCCTGATCTTCCAGGGTGG
GGAGGAGAAAATCCCACCTCCCCTGACCTCCACCACCTCCACCACCACCACCACCACCAC
CACCACCACTACCACCACCACCCAACTGGGGCTAGAGTGGGGAAGATTTCCCCTTTAGAT
CAAACTGCCCCTTCCATGGAAAAGCTGGAAAAAAACTCTGGAACCCATATCCAGGCTTGG
TGAGGTTGCTGCCAACAGTCCTGGCCTCCCCCATCCCTAGGCTAAAGAGCCATGAGTCCT
GGAGGAGGAGAGGACCCCTCCCAAAGGACTGGAGACAAAACCCTCTGCTTCCTTGGGTCC
CTCCAAGACTCCCTGGGGCCCAACTGTGTTGCTCCACCCGGACCCATCTCTCCCTTCTAG
ACCTGAGCTTGCCCCTCCAGCTAGCACTAAGCAACATCTCGCTGTGGACGCCTGTAAATT
ACTGAGAAATGTGAAACGTGCAATCTTGAAACTGAGGTGTTAGAAAACTTGATCTGTGGT
GTTTTGTTTTGTTTTTTTTCTTAAAACAACAGCAACGTGATCTTGGCTGTCTGTCATGTG
TTGAAGTCCATGGTTGGGTCTTGTGAAGTCTGAGGTTTAACAGTTTGTTGTCCTGGAGGG
ATTTTCTTACAGCGAAGACTTGAGTTCCTCCAAGTCCCAGAACCCCAAGAATGGGCAAGA
AGGATCAGGTCAGCCACTCCCTGGAGACACAGCCTTCTGGCTGGGACTGACTTGGCCATG
TTCTCAGCTGAGCCACGCGGCTGGTAGTGCAGCCTTCTGTGACCCCGCTGTGGTAAGTCC
AGCCTGCCCAGGGCTGCTGAGGGCTGCCTCTTGACAGTGCAGTCTTATCGAGACCCAACG
CCTCAGTCTGCTCATCCGTAAAGTGGGGATAGTGAAGATGACACCCCTCCCCACCACCTC
TCATAAGCACTTTAGGAACACACAGAGGGTAGGGATAGTGGCCCTGGCCGTCTATCCTAC
CCCTTTAGTGACCGCCCCCATCCCGGCTTTCTGAGCTGATCCTTGAAGAAGAAATCTTCC
ATTTCTGCTCTCAAACCCTACTGGGATCAAACTGGAATAAATTGAAGACAGCCAGGGGGA
TGGTGCAGCTGTGAAGCTCGGGCTGATTCCCCCTCTGTCCCAGAAGGTTGGCCAGAGGGT
GTGACCCAGTTACCCTTTAACCCCCACCCTTCCAGTCGGGTGTGAGGGCCTGACCGGGCC
CAGGGCAAGCAGATGTCGCAAGCCCTATTTATTCAGTCTTCACTATAACTCTTAGAGTTG
AGACGCTAATGTTCATGACTCCTGGCCTTGGGATGCCCAAGGGATTTCTGGCTCAGGCTG
TAAAAGTAGCTGAGCCATCCTGCCCATTCCTGGAGGTCCTACAGGTGAAACTGCAGGAGC
TCAGCATAGACCCAGCTCTCTGGGGGATGGTCACCTGGTGATTTCAATGATGGCATCCAG
GAATTAGCTGAGCCAACAGACCATGTGGACAGCTTTGGCCAGAGCTCCCGTGTGGCATCT
GGGAGCCACAGTGACCCAGCCACCTGGCTCAGGCTAGTTCCAAATTCCAAAAGATTGGCT
TGTAAACCTTCGTCTCCCTCTCTTTTACCCAGAGACAGCACATACGTGTGCACACGCATG
CACACACACATTCAGTATTTTAAAAGAATGTTTTCTTGGTGCCATTTTCATTTTATTTTA
TTTTTTAATTCTTGGAGGGGGAAATAAGGGAATAAGGCCAAGGAAGATGTATAGCTTTAG
CTTTAGCCTGGCAACCTGGAGAATCCACATACCTTGTGTATTGAACCCCAGGAAAAGGAA
GAGGTCGAACCAACCCTGCGGAAGGAGCATGGTTTCAGGAGTTTATTTTAAGACTGCTGG
GAAGGAAACAGGCCCCATTTTGTATATAGTTGCAACTTAAACTTTTTGGCTTGCAAAATA
TTTTTGTAATAAAGATTTCTGGGTAATAATGAAAAAAAAAAAAAAAAAACTCGAC
>OriGene 5' read for NM_080792 unedited
AACTTTTGGATTTTGTAACACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCCC
TGGCTTTATTTCTCGCGCGCTTGGGGTCTCTCCCAGTCTCCGTCTCTCCATTTCTCCTGG
GGGGCGGGGAGGGGGGGTCTCCAAAAACCGCGGCGGCGGCGGCGGCCGCTCCAGGCGCCC
GTTCCGGAGTCGGGGGGAGGCCCAGCCGGGAGGGGGGAATGGGGGGAGCCTTATTCATTT
CCCCGCTCCAGCCTGCTCCCGCCCGAGCGCGCACTCACGGCCGCTCTCCCTCCTCGCTCC
GCAGCCGCGGCCCATGGAGCCCGCCGGCCCGGCCCCCGGCCGCCTCGGGCCGCTGCTCTG
CCTGCTGCTCGCCGCGTCCTGCGCCTGGTCAGGAGTGGCGGGTGAGGAGGAGCTGCAGGT
GATTCAGCCTGACAAGTCCGTGTTGGTTGCAGCTGGAGAGACAGCCACTCTGCGCTGCAC
TGCGACCTCTCTGATCCCTGTGGGGCCCATCCAGTGGTTCAGAGGAGCTGGACCAGGCCG
GGAATTAATCTACAATCAAAAAGAAAGCCACTTCCCCCGGGTAACAACTGTTTCAGACCT
CACAAAGAGAAACAACATGGACTTTTCCATCCGCATCGGTAACATCACCCCAGCAGATGC
CGGCACCTACTACTGTGTGAAGTTCCGGATAGGGAGCCCCGATGACGTGGAGTTTAAGTC
TGGAGCAGGCACTGAGCTGTCTGTGCGCGCCAAACCCTCTGCCCCCGTGGTATCGGGCCC
TGCGGCGAGGGCCACACCTCAGCACACAGTGAGCTTCACCTGCGAGTCCCACGGCTTCTC
ACCAGAGACTCACCCTGAAATGGTTCANAAATGGGGATGAGCTCTCAGACTTNCAGACAA
CGTGGACCCCCGTAGAGAGAGCGTGTCCTACAGCATG
>OriGene 3' read for NM_080792 unedited
ACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCATTATTACCCAAAAAT
CTTTATTACAAAAATATTTTGCAAGCCAAAAGTTTAAGTTGCAACTATATACAAAATGGG
GCCTGTTTCCTTCCCAGCAGTCTTAAAATAAACTCCTGAAACCATGCTCCTTCCGCAGGG
TTGGTTCGACCTCTTCCTTTTCCTGGGGTTCAATACACAAGGTATGTGGATTCTCCAGGT
TGCCAGGCTAAAGCTAAAGCTATACATCTTCCTTGGCCTTATTCCCTTATTTCCCCCTCC
AAGAATTAAAAAATAAAATAAAATGAAAATGGCACCAAGAAAACATTCTTTTAAAATACT
GAATGTGTGTGTGCATGCGTGTGCACACGTATGTGCTGTCTCTGGGTAAAAGAGAGGGAG
ACGAAGGTTTACAAGCCAATCTTTTGGAATTTGGAACTAGCCTGAGCCAGGTGGCTGGGT
CACTGTGGCTCCCAGATGCCACACGGGAGCTCTGGCCAAAGCTGTCCACATGGTCTGTTG
GCTCAGCTAATTCCTGGATGCCATCATTGAAATCACCAGGTGACCATCCCCCAGAGAGCT
GGGTCTATGCTGAGCTCCTGCAGTTTCACCTGTAGGACCTCCAGGAATGGGCAGGATGGC
TCAGCTACTTTTACAGCCTGAGCCAGAAATCCCTTGGGCATCCCAAGGCCAGGAGTCATG
AACATTAGCGTCTCAACTCTAAGAGTATAGTGAAGACTGAAAAATAGGGCTTGCGACATC
TGCTTGCCCTGGGCCCNGTCAGGCCCTCACACCCGACTGGAGGGTGGGGGGNTAAGGGGT
ACTGGGTCACACCCTTGGCCACCTTCTGGACAGAGGGGAAATANCCGAGCTTACACTGCA
CATCCCCTGGCTGNCTCAATTATTCAA
Restriction Sites NotI-NotI     
ACCN NM_080792
ORF Size 1515 bp
Insert Size 3860
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_080792.1, NP_542970.1
RefSeq Size 3872
RefSeq ORF 1515
Locus ID 140885
Domains ig, IGv, IGc1, IG
Protein Families Druggable Genome, Phosphatase, Transmembrane
Gene Summary The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate, in-frame, splice donor site in the 3' coding region compared to variant 4. This variant encodes a shorter protein (isoform 1) compared to isoform 2. Variants 1, 2, and 3 encode the same protein (isoform 1).

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