BACE1 (NM_138972) Human Untagged Clone

CAT#: SC120577

BACE1 (untagged)-Human beta-site APP-cleaving enzyme 1 (BACE1), transcript variant b

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BACE1
• Synonyms: ASP2; BACE; HSPC104
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_138972, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCCAAGCCCTGCCCTGGCTCCTGCTGTGGATGGGCGCGGGAGTGCTGCCTGCCCACGGCACCCAGC
  ACGGCATCCGGCTGCCCCTGCGCAGCGGCCTGGGGGGCGCCCCCCTGGGGCTGCGGCTGCCCCGGGAGAC
  CGACGAAGAGCCCGAGGAGCCCGGCCGGAGGGGCAGCTTTGTGGAGATGGTGGACAACCTGAGGGGCAAG
  TCGGGGCAGGGCTACTACGTGGAGATGACCGTGGGCAGCCCCCCGCAGACGCTCAACATCCTGGTGGATA
  CAGGCAGCAGTAACTTTGCAGTGGGTGCTGCCCCCCACCCCTTCCTGCATCGCTACTACCAGAGGCAGCT
  GTCCAGCACATACCGGGACCTCCGGAAGGGTGTGTATGTGCCCTACACCCAGGGCAAGTGGGAAGGGGAG
  CTGGGCACCGACCTGGTAAGCATCCCCCATGGCCCCAACGTCACTGTGCGTGCCAACATTGCTGCCATCA
  CTGAATCAGACAAGTTCTTCATCAACGGCTCCAACTGGGAAGGCATCCTGGGGCTGGCCTATGCTGAGAT
  TGCCAGGCTTTGTGGTGCTGGCTTCCCCCTCAACCAGTCTGAAGTGCTGGCCTCTGTCGGAGGGAGCATG
  ATCATTGGAGGTATCGACCACTCGCTGTACACAGGCAGTCTCTGGTATACACCCATCCGGCGGGAGTGGT
  ATTATGAGGTGATCATTGTGCGGGTGGAGATCAATGGACAGGATCTGAAAATGGACTGCAAGGAGTACAA
  CTATGACAAGAGCATTGTGGACAGTGGCACCACCAACCTTCGTTTGCCCAAGAAAGTGTTTGAAGCTGCA
  GTCAAATCCATCAAGGCAGCCTCCTCCACGGAGAAGTTCCCTGATGGTTTCTGGCTAGGAGAGCAGCTGG
  TGTGCTGGCAAGCAGGCACCACCCCTTGGAACATTTTCCCAGTCATCTCACTCTACCTAATGGGTGAGGT
  TACCAACCAGTCCTTCCGCATCACCATCCTTCCGCAGCAATACCTGCGGCCAGTGGAAGATGTGGCCACG
  TCCCAAGACGACTGTTACAAGTTTGCCATCTCACAGTCATCCACGGGCACTGTTATGGGAGCTGTTATCA
  TGGAGGGCTTCTACGTTGTCTTTGATCGGGCCCGAAAACGAATTGGCTTTGCTGTCAGCGCTTGCCATGT
  GCACGATGAGTTCAGGACGGCAGCGGTGGAAGGCCCTTTTGTCACCTTGGACATGGAAGACTGTGGCTAC
  AACATTCCACAGACAGATGAGTCAACCCTCATGACCATAGCCTATGTCATGGCTGCCATCTGCGCCCTCT
  TCATGCTGCCACTCTGCCTCATGGTGTGTCAGTGGCGCTGCCTCCGCTGCCTGCGCCAGCAGCATGATGA
  CTTTGCTGATGACATCTCCCTGCTGAAGTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_138972 unedited
  TACTATAGGGGCGGCCGCGAATTCGCACGAGGTGCGGATCTCCCCTGACCGCTCTCCACA
  GCCCGGACCCGGGGGCTGGCCCAGGGCCCTGCAGGCCCTGGCGTCCTGATGCCCCCAAGC
  TCCCTCTCCTGAGAAGCCACCAGCACCACCCAGACTTGGGGGCAGGCGCCAGGGACGGAC
  GTGGGCCAGTGCGAGCCCAGAGGGCCCGAAGGCCGGGGCCCACCATGGCCCAAGCCCTGC
  CCTGGCTCCTGCTGTGGATGGGCGCGGGAGTGCTGCCTGCCCACGGCACCCAGCACGGCA
  TCCGGCTGCCCCTGCGCAGCGGCCTGGGGGGCGCCCCCCTGGGGCTGCGGCTGCCCCGGG
  AGACCGACGAAGAGCCCGAGGAGCCCGGCCGGAGGGGCAGCTTTGTGGAGATGGTGGACA
  ACCTGAGGGGCAAGTCGGGGCAGGGCTACTACGTGGAGATGACCGTGGGCAGCCCCCCGC
  AGACGCTCAACATCCTGGTGGATACAGGCAGCAGTAACTTTGCAGTGGGTGCTGCCCCCC
  ACCCCTTCCTGCATCGCTACTACCAGAGGCAGCTGTCCAGCACATACCGGGACCTCCGGA
  AGGGTGTGTATGTGCCCTACACCCAGNGCAAGTGGGAAGGGGAGCTGGGCACCGACCTGT
  TAAGCATTCCCCATGGCCCCAACGTCACTGTGCGTGCCCACATTGCTGCCATCACTGAAT
  CANACAGGTTCTTCATCAACGGCTCCACTGGNGAAGCATCCTGGGGCTGGCCTATGCTGA
  GATGCCAAGCCTGACGACTCCCTGGAGCCTTTNTTTGACTCTCTGGTAAGCAGAACCACG
  TTCCAACCTCTTCTCCTGCACCTTTGGGG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_138972 unedited
  GGAATATTATGNACGCGGCCGCATTCTANNATCGAGTTTTTTTTTTTTTTTTTTTTTTTT
  CTTATTGAATATTTTACTGTGTTAACGCTCATTATTTATACAGACATTAGGTTTACAGAA
  TATTCTGTTTTACATCACCAAAATTCACAGTCCGAGAATAACAACATAACCAGGTCCCAA
  TTCCTCCATGCACCCCACAAGCTTCTGTCCACCCTATTTTCTGGACAGAAATTAGCACAA
  CCCACAGGTTTTTCCTGGGCCAAGTCTTCCTTTGCTGCCACTGTCTTGGCTTCTAATCAA
  GCTCTGACAGGCCAACATTGTGAAGTCCTCACCCTTTCCCATTCACTTCTGGTCTCCTAG
  TCTAGCTAATCCCCCTCCCCCAGAAGGTTAAGGCAGTTGGTTCACAACCAAGTTGTTTGG
  TGACCTTGGGTGAGCTCCAGACAGGCACTGGGGTGAGGAGATGTCTGTGCAAAATTACTT
  GTAGAATGATCTTGGGATGCTGGATTTTAATTTTTGAAGCAAGAAAGTTAGGGGGGGACA
  TATTTCCTGTCCTGGGAAAAATGGAGACCAAAGTGATATTAAGAAAGTAGTTTGGATTTC
  AAATTTATAAATCACTTGCTCTGTGGGTAGCTATCAGGAACTAGATCATTTTCCACCTCT
  GCTTATTGTACTTCTTAATTTTAGGTTTTATACCTGGGAAAGCTGTGACTCTATTAGAGC
  TTTGAATCTTTTCCTATCCTTTTATCTTTACTCCTACAGGGAATGGCCTCAGCTCCCTTC
  TCTTTTAGATTAAACAAGTAAAAACTAAGAGTTAACTTTTTAAAAAAACTGACTCCCGGG
  AAAGGACATTATTATATTACCAATAGCTGATTTTTTTTTTCATTCTGGGACCTAAAAGCT
  TACAGTACTAN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_138972
• ORF Size: 1431 bp
• Insert Size: 5650
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_138972.2, NP_620428.1
• RefSeq Size: 5775
• RefSeq ORF: 1431
• Locus ID: 23621
• Domains: asp
• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: Alzheimer's disease
• Gene Summary: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]
  Transcript Variant: This variant (b) has an alternate splice site in the coding region, compared to variant a. The resulting isoform (B) lacks an internal segment, compared to isoform A. This isoform (B) may not undergo proteolytic processing similar to isoform A.