Cytochrome P450 2A6 (CYP2A6) (NM_000762) Human Untagged Clone

CAT#: SC120818

CYP2A6 (untagged)-Human cytochrome P450, family 2, subfamily A, polypeptide 6 (CYP2A6)


  "NM_000762" in other vectors (4)

Reconstitution Protocol

SC120818 is the updated version of SC119672.

USD 830.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CYP2A6
Synonyms CPA6; CYP2A; CYP2A3; CYPIIA6; P450C2A; P450PB
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC120818 sequence for NM_000762 edited (data generated by NextGen Sequencing)
ATGCTGGCCTCAGGGATGCTTCTGGTGGCCTTGCTGGTCTGCCTGACTGTGATGGTCTTG
ATGTCTGTTTGGCAGCAGAGGAAGAGCAAGGGGAAGCTGCCTCCGGGACCCACCCCATTG
CCCTTCATTGGAAACTACCTGCAGCTGAACACAGAGCAGATGTACAACTCCCTCATGAAG
ATCAGTGAGCGCTATGGCCCCGTGTTCACCATTCACTTGGGGCCCCGGCGGGTCGTGGTG
CTGTGTGGACATGATGCCGTCAGGGAGGCTCTGGTGGACCAGGCTGAGGAGTTCAGCGGG
CGAGGCGAGCAAGCCACCTTCGACTGGGTCTTCAAAGGCTATGGCGTGGTATTCAGCAAC
GGGGAGCGCGCCAAGCAGCTCCGGCGCTTCTCCATCGCCACCCTGCGGGACTTCGGGGTG
GGCAAGCGAGGCATCGAGGAGCGCATCCAGGAGGAGGCGGGCTTCCTCATCGACGCCCTC
CGGGGCACTGGCGGCGCCAATATCGATCCCACCTTCTTCCTGAGCCGCACAGTCTCCAAT
GTCATCAGCTCCATTGTCTTTGGGGACCGCTTTGACTATAAGGACAAAGAGTTCCTGTCA
CTGTTGCGCATGATGCTAGGAATCTTCCAGTTCACGTCAACCTCCACGGGGCAGCTCTAT
GAGATGTTCTCTTCGGTGATGAAACACCTGCCAGGACCACAGCAACAGGCCTTTCAGTTG
CTGCAAGGGCTGGAGGACTTCATAGCCAAGAAGGTGGAGCACAACCAGCGCACGCTGGAT
CCCAATTCCCCACGGGACTTCATTGACTCCTTTCTCATCCGCATGCAGGAGGAGGAGAAG
AACCCCAACACGGAGTTCTACTTGAAAAACCTGGTGATGACCACGTTGAACCTCTTCATT
GGGGGCACCGAGACCGTCAGCACCACCCTGCGCTATGGCTTCTTGCTGCTCATGAAGCAC
CCAGAGGTGGAGGCCAAGGTCCATGAGGAGATTGACAGAGTGATCGGCAAGAACCGGCAG
CCCAAGTTTGAGGACCGGGCCAAGATGCCCTACATGGAGGCAGTGATCCACGAGATCCAA
AGATTTGGAGACGTGATCCCCATGAGTTTGGCCCGCAGAGTCAAAAAGGACACCAAGTTT
CGGGATTTCTTCCTCCCTAAGGGCACCGAAGTGTACCCTATGCTGGGCTCTGTGCTGAGA
GACCCCAGTTTCTTCTCCAACCCCCAGGACTTCAATCCCCAGCACTTCCTGAATGAGAAG
GGGCAGTTTAAGAAGAGTGATGCTTTTGTGCCCTTTTCCATCGGAAAGCGGAACTGTTTC
GGAGAAGGCCTGGCCAGAATGGAGCTCTTTCTCTTCTTCACCACCGTCATGCAGAACTTC
CGCCTCAAGTCCTCCCAGTCACCTAAGGACATTGACGTGTCCCCCAAACACGTGGGCTTT
GCCACGATCCCACGAAACTACACCATGAGCTTCCTGCCCCGCTGA

Clone variation with respect to NM_000762.5
51 a=>g
>OriGene 5' read for NM_000762 unedited
AGGAATTTGTAATACGACTCACTATAGGCGGCCCGCGAATTCGCACCATCCACCATGCTG
GCCTCAGGGATGCTTCTGGTGGCCTTGCTGGTCTGCCTGACTGTGATGGTCTTGATGTCT
GTTTGGCAGCAGAGGAAGATCAAGGGGAAGCTGCCTCCGGGACCCACCCCATTGCCCTTC
ATTGGAAACTACCTGCAGCTGAACACAGAGCAGATGTACAACTCCCTCATGAAGATCAGT
GAGCGCTATGGCCCCGTGTTCACCATTCACTTGGGGCCCCGGCGGGTCGTGGTGCTGTGT
GGACATGATGCCGTCAGGGAGGCTCTGGTGGACCATGCTGAAGAGTTCAGCGGGCGATGC
GAGCAAGCCACCTTCGACTGGGTCTTCAAAGGCTATGGCGTGGTATTCAGCAACGGGGAG
CGCGCCAAGCAGCTCCGGCGCTTCTCCATCGCCACCCTGCGGGACTTCGGGGTGGGCAAG
CGAGGCATCGAGGAGCGCATCCAGGATGATGCGGGCTTCCTCATCGACGCCCTCCGGGGC
ACTGGCGGCGCCAATATCGATCCCACCTTCTTCCTGAGCCGCACAGTCTCCAATGTCATC
AGCTCCATTGTCTTTGGGGACCGCTTTGACTATAAAGACAAAGAGTTCCTGTCACTGTTG
CGCATGATGCTAAGAATCTTCCAGTTCACGTCAACCTCCACGGAGCAGCTCTATGAGATG
TTCTCTTCGGTGATGAAACACCTGCCATGACCACAGCATCAGGCCTTTCATTTGCTGCAA
GGGCTGGATGACTTCATAGCCAAGAATGTGGAGCACAACCAGCGCACGCTGGATCCCANN
TCCCACGGNACTCATTGACTCCTTCTATCGCTGCAGGAGGATGATATATCCCACACGNGT
TCTACTGAAACCTGTGATGACACGCTGACTCTCATGGGGGCACGAGACGTAGCACACCTG
GCTT
>OriGene 3' read for NM_000762 unedited
CGGATTGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTCAGGAAACAGCT
ATGACCTTGGCCGCAATCTAGAGTCGAGTTTTTTTTTGGTTTTTTTTCAGGAAATAAGAG
CTGCTATTATTACTACTCTTCATAGCATAATGTAAGGGTTTCCTTCCTCTCATCCCAGCT
CGGAAGCACCTTATCAAGGTGAACTGAGCCCCTTCTGTTTCTTCTCTTCCCTCTAGCCAC
CACGCCCCTTCCTTTCCCGCATCTTCCCCCCATTCTTATACCCGCCTCTTCCGCGAACCC
CGCCCTGACCCCGCCTTTCCCTGGCCCCGCCCACCAGACCTGCACCGGCACAGCCCTCGC
TCAGCGGGGCAGGAAGCTCATGGTGTAGTTTCGTGGGATCGTGGCAAAGCCCACGTGTTT
GGGGGACACGTCAATGTCCTTAGGTGACTGGGAGGACTTGAGGCGGAAGTTCTGCATGAC
GGTGGTGAAGAAGAGAAAGAGCNTCATTCTGCCCAGCCTTCTCGANACAGTTTCGCTTTC
CGATGGAAAAGGCACANNAGCATCACTCTTCTTTAACTGCCCCTTCTATTCANGAAGTGC
NTGGGATTGAAGTCTTGNGGGTTGAGAAGAAAACTGGGTCTCTCACACAAAAGCCAGCAT
TAGGTACACTTCGGTGCCTTTAGGGAAGAAGGATCCCCGAANCTGTGGTTCTTTTGACTC
TGCGGGCAAACTCATGGGGTTCACTTTCAATTCTTTGAATCTCGGATCCACTGCTCCGTG
G
Restriction Sites NotI-NotI     
ACCN NM_000762
Insert Size 1800 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000762.4, NP_000753.2
RefSeq Size 1751 bp
RefSeq ORF 1485 bp
Locus ID 1548
Cytogenetics 19q13.2
Domains p450
Protein Families Druggable Genome, P450, Transmembrane
Protein Pathways Caffeine metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Retinol metabolism
Gene Summary 'This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008]'

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