IBRDC2 (RNF144B) (NM_182757) Human Untagged Clone

CAT#: SC121747

RNF144B (untagged)-Human ring finger protein 144B (RNF144B)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RNF144B
• Synonyms: bA528A10.3; IBRDC2; p53RFP; PIR2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC121747 sequence for NM_182757 edited (data generated by NextGen Sequencing)
  ATGGGCTCAGCTGGTAGGCTCCACTATCTCGCCATGACTGCTGAAAATCCCACTCCTGGA
  GACCTGGCTCCGGCCCCCCTCATCACTTGCAAACTCTGCCTGTGTGAGCAGTCTCTGGAC
  AAGATGACCACACTCCAGGAATGCCAGTGCATCTTTTGCACAGCTTGCCTGAAACAGTAC
  ATGCAGCTGGCAATCCGAGAAGGATGTGGGTCTCCCATCACTTGCCCTGACATGGTGTGC
  CTAAACCACGGGACCCTGCAGGAAGCTGAGATTGCCTGTTTGGTACCTGTGGACCAGTTT
  CAACTTTATCAGAGGTTAAAATTTGAAAGAGAAGTTCATCTGGACCCCTACCGAACATGG
  TGTCCTGTTGCAGACTGTCAGACAGTGTGCCCTGTTGCCTCGAGTGACCCAGGACAGCCT
  GTGCTGGTGGAATGCCCTTCTTGCCACCTGAAATTCTGCTCGTGTTGCAAGGATGCTTGG
  CATGCAGAGGTCTCCTGTAGAGACAGTCAGCCTATTGTCCTGCCAACAGAGCACCGAGCC
  CTCTTTGGGACAGATGCAGAAGCCCCCATTAAGCAGTGCCCAGTTTGCCGGGTTTATATC
  GAACGCAATGAAGGCTGCGCTCAGATGATGTGCAAAAACTGCAAGCATACATTTTGCTGG
  TACTGCCTCCAGAACTTGGATAATGACATTTTCCTCAGACATTATGACAAAGGGCCATGC
  AGGAATAAACTTGGCCACTCAAGAGCATCAGTGATGTGGAACCGAACACAGGTGGTGGGG
  ATTCTCGTAGGCTTGGGCATCATTGCCTTGGTTACTTCACCCTTGTTACTCCTGGCCTCC
  CCATGTATAATCTGTTGTGTCTGCAAGTCCTGTCGGGGCAAGAAGAAAAAGCACGACCCA
  TCCACAACCTAA
  
  Clone variation with respect to NM_182757.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_182757 unedited
  GCCGCGAATTCGGCACGAGCAGAGCACGGAGGAAAGACGGAGAGAATGGAAGAGCTCCTG
  TCCGGTGTGCCAGCAGCCCGGACTGGCGGTGAGCGCGAGGGAGGCTACTGAGAAGCCCGG
  CGACGGAGGAACGCAGGTCTGCTGCCAGGGATTGAGGAGACTGAAGAACGCTGAAGACAG
  GCTGATGGGCTCAGCTGGTAGGCTCCACTATCTCGCCATGACTGCTGAAAATCCCACTCC
  TGGAGACCTGGCTCCGGCCCCCCTCATCACTTGCAAACTCTGCCTGTGTGAGCAGTCTCT
  GGACAAGATGACCACACTCCAGGAATGCCAGTGCATCTTTTGCACAGCTTGCCTGAAACA
  GTACATGCAGCTGGCAATCCGAGAAGGATGTGGGTCTCCCATCACTTGCCCTGACATGGT
  GTGCCTAAACCACGGGACCCTGCAGGAAGCTGAGATTGCCTGTTTGGTACCTGTGGACCA
  GTTTCAACTTTATCAGAGGTTAAAATTTGAAAGAGAAGTTCATCTGGACCCCTACCGAAC
  ATGGTGTCCTGTTGCAGACTGTCAGACAGTGTGCCCTGTTGCCTCGAGTGACCCAGGACA
  GCCTGTGCTGGTGGAATGCCCTTCTTGCCACCTGAAATTCTGCTCGTGTTGCAAGGATGC
  TTGGCATGCANAGGTCTNCTGTANAGACAGTCAGCCTATTGTCCTGCCACAGAGCACCGA
  GCCCTCTTTGGGACAGATGCAGAAGCCCC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_182757
• ORF Size: 912 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_182757.2, NP_877434.2
• RefSeq Size: 4782
• RefSeq ORF: 912
• Locus ID: 255488
• Protein Families: Transmembrane
• Gene Summary: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. [UniProtKB/Swiss-Prot Function]