TCF7 (NM_201633) Human Untagged Clone

CAT#: SC121841

TCF7 (untagged)-Human transcription factor 7 (T-cell specific, HMG-box) (TCF7), transcript variant 3


Reconstitution Protocol

USD 660.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol TCF7
Synonyms FLJ36364; MGC47735; OTTHUMP00000159391; TCF-1; Transcription factor-7, T-cell specific; transcription factor 7 (T-cell specific, HMG-box)
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_201633, the custom clone sequence may differ by one or more nucleotides


ATGTACAAAGAGACCGTCTACTCCGCCTTCAATCTGCTCATGCATTACCCACCCCCCTCGGGAGCAGGGC
AGCACCCCCAGCCGCAGCCCCCGCTGCACAAGGCCAATCAGCCCCCCCACGGTGTCCCCCAACTCTCTCT
CTACGAACATTTCAACAGCCCACATCCCACCCCTGCACCTGCGGACATCAGCCAGAAGCAAGTTCACAGG
CCTCTGCAGACCCCTGACCTCTCTGGCTTCTACTCCCTGACCTCAGGCAGCATGGGGCAGCTCCCCCACA
CTGTGAGCTGGTTCACCCACCCATCCTTGATGCTAGGTTCTGGTGTACCTGGTCACCCAGCAGCCATCCC
CCACCCGGCCATTGTGCCCCCCTCAGGGAAGCAGGAGCTGCAGCCCTTCGACCGCAACCTGAAGACACAA
GCAGAGTCCAAGGCAGAGAAGGAGGCCAAGAAGCCAACCATCAAGAAGCCCCTCAATGCCTTCATGCTGT
ACATGAAGGAGATGAGAGCCAAGGTCATTGCAGAGTGCACACTTAAGGAGAGCGCTGCCATCAACCAGAT
CCTGGGCCGCAGGTGGCACGCGCTGTCGCGAGAAGAGCAGGCCAAGTACTATGAGCTGGCCCGCAAGGAG
AGGCAGCTGCACATGCAGCTATACCCAGGCTGGTCAGCGCGGGACAACTACGGGAAGAAGAAGAGGCGGT
CGAGGGAAAAGCACCAAGAATCCACCACAGAGACAAACTGGCCCAGAGAACTCAAGGATGGTAATGGACA
AGAGTCACTGTCCATGTCTTCTTCCTCTAGCCCAGCTTGA


>OriGene 5' read for NM_201633 unedited
GACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCGGGGGCCGGCGCCGGGGCCCGCG
GCGAGGCCGAGGCTCTCGGGCGGGAACACGCTGCGCAGAGACTCTTCCCGGACAAACTTC
CAGAGCCCCTGGAGGACGGCCTGAAGGCCCCGGAGTGCACCAGCGGCATGTACAAAGAGA
CCGTCTACTCCGCCTTCAATCTGCTCATGCATTACCCACCCCCCTCGGGAGCAGGGCAGC
ACCCCCAGCCGCAGCCCCCGCTGCACAAGGCCAATCAGCCCCCCCACGGTGTCCCCCAAC
TCTCTCTCTACGAACATTTCAACAGCCCACATCCCACCCCTGCACCTGCGGACATCAGCC
AGAAGCAAGTTCACAGGCCTCTGCAGACCCCTGACCTCTCTGGCTTCTACTCCCTGACCT
CAGGCAGCATGGGGCAGCTCCCCCACACTGTGAGCTGGCCCAGCCCTCCTCTCTACCCCC
TGTCCCCTTCCTGCGGATATAGACANGCACTTCCCTGCCCCCACTGCAGCCCCTGGCGCC
CCCTACCCCAGGTTCACCCACCCATCCTTGATGCTAGGTTCTGGTGTACCTGGTCACCCA
GCAGCCATCCCCCACCCGGCCATTGTGCCCCCCTCAGGGAAAGCAGAGCTGCAGCCCTTC
GACNCCGCACCTGAGACACAAGCAGAGTCCAAGGCAGAGAAGGAGGCCAAGAAGCCAACC
ATCAAGAAGCCCCTCATGCCTTCATGCTGTACATGAAGGGAGATGAGAGCCCAGGTCATT
GCAGAGTGACACTTAAAGAGAGCGCTGCATCACCAGATCCTGGCCGCGAGTGCACGCGCT
GTCGCAGAAAAAGCAGCCCAGTACTATGACCTGCCCCGAAGGAAAGGCAGCTGCCATGCA
CTATCCCAGCTGGTCACGCGGAACTACGGAAAAAAAAAAAGCGGGCCGGGGAAACCCCAG
AATCCCACGGAGAAAGATTGCCTCGACTACCCCGGAAAGCCT
Restriction Sites NotI-NotI     
ACCN NM_201633
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_201633.1, NP_963964.1
RefSeq Size 1254 bp
RefSeq ORF 810 bp
Locus ID 6932
Cytogenetics 5q31.1
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
Protein Pathways Acute myeloid leukemia, Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Melanogenesis, Pathways in cancer, Prostate cancer, Thyroid cancer, Wnt signaling pathway
Gene Summary 'This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]'
Transcript Variant: This variant (3) differs in the 5' UTR and has multiple differences in the 5' and 3' coding region, compared to variant 1. These differences cause translation initiation from a downstream ATG and a protein isoform (3) with a distinct C-terminus, compared to isoform 1.

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