CACNB3 (NM_000725) Human Untagged Clone

CAT#: SC122090

CACNB3 (untagged)-Human calcium channel, voltage-dependent, beta 3 subunit (CACNB3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CACNB3
• Synonyms: CAB3; CACNLB3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_000725 edited
  GTCGAGAGCGGGTGGGGGGAGCGGTGATCTGAGCTCCGAGCAGCTGGTCTTCGCGGCTCG
  CTCCCTCCTTCGCGCTCTCTCGCTCCCTGCCGCCGCCCGCAGGGCTGCGGGGCTCGGTGG
  CATCTCCCGGGCGCGGCCCGCAGTCCTTGCCCCTGCCTCCGGGCCGCTCCCGCCCCCGGC
  GCCGCTCGCTCCCCCGACCCGGACTCCCCCATGTATGACGACTCCTACGTGCCCGGGTTT
  GAGGACTCGGAGGCGGGTTCAGCCGACTCCTACACCAGCCGCCCATCTCTGGACTCAGAC
  GTCTCCCTGGAGGAGGACCGGGAGAGTGCCCGGCGTGAAGTAGAGAGCCAGGCTCAGCAG
  CAGCTCGAAAGGGCCAAGCACAAACCTGTGGCATTTGCGGTGAGGACCAATGTCAGCTAC
  TGTGGCGTACTGGATGAGGAGTGCCCAGTCCAGGGCTCTGGAGTCAACTTTGAGGCCAAA
  GATTTTCTGCACATTAAAGAGAAGTACAGCAATGACTGGTGGATCGGGCGGCTAGTGAAA
  GAGGGCGGGGACATCGCCTTCATCCCCAGCCCCCAGCGCCTGGAGAGCATCCGGCTCAAA
  CAGGAGCAGAAGGCCAGGAGATCTGGGAACCCTTCCAGCCTGAGTGACATTGGCAACCGA
  CGCTCCCCTCCGCCATCTCTAGCCAAGCAGAAGCAAAAGCAGGCGGAACATGTTCCCCCA
  TATGACGTGGTGCCCTCCATGCGGCCTGTGGTGCTGGTGGGACCATCTCTGAAAGGTTAT
  GAGGTCACAGACATGATGCAGAAGGCTCTCTTCGACTTCCTCAAACACAGATTTGATGGC
  AGGATCTCCATCACCCGAGTCACAGCCGACCTCTCCCTGGCAAAGCGATCTGTGCTCAAC
  AATCCGGGCAAGAGGACCATCATTGAGCGCTCCTCTGCCCGCTCCAGCATTGCGGAAGTG
  CAGAGTGAGATCGAGCGCATATTTGAGCTGGCCAAATCCCTGCAGCTAGTAGTGTTGGAC
  GCTGACACCATCAACCACCCAGCACAGCTGGCCAAGACCTCGCTGGCCCCCATCATCGTC
  TTTGTCAAAGTGTCCTCACCAAAGGTACTCCAGCGTCTCATTCGCTCCCGGGGGAAGTCA
  CAGATGAAGCACCTGACCGTACAGATGATGGCATATGATAAGCTGGTTCAGTGCCCACCG
  GAGTCATTTGATGTGATTCTGGATGAGAACCAGCTGGAGGATGCCTGTGAGCACCTGGCT
  GAGTACCTGGAGGTTTACTGGCGGGCCACGCACCACCCAGCCCCTGGCCCCGGACTTCTG
  GGTCCTCCCAGTGCCATCCCGGGACTTCAGAACCAGCAGCTGCTGGGGGAGCGTGGCGAG
  GAGCACTCCCCCCTTGAGCGGGACAGCTTGATGCCCTCTGATGAGGCCAGCGAGAGCTCC
  CGCCAAGCCTGGACAGGATCTTCACAGCGTAGCTCCCGCCACCTGGAGGAGGACTATGCA
  GATGCCTACCAGGACCTGTACCAGCCTCACCGCCAACACACCTCGGGGCTGCCTAGTGCT
  AACGGGCATGACCCCCAAGACCGGCTTCTAGCCCAGGACTCAGAGCACAACCACAGTGAC
  CGGAACTGGCAGCGCAACCGGCCTTGGCCCAAGGATAGCTACTGACAGCCTCCTGCTGCC
  CTACCCTGGCAGGCACAGGCGCAGCTGGCTGGGGGGCCCACTCCAGGCAGGGTGGCGTTA
  GACTGGCATCAGGCTGGCACTAGGCTCAGCCCCCAAAACCCCCTGCCCAGCCCCAGCTTC
  AGGGCTGCCTGTGGTCCCAAGGTTCTGGGAGAAACAGGGGACCCCCTCACCTCCTGGGCA
  GTGACCCCTACTAGGCTCCCATTCCAGGTACTAGCTGTGTGTTCTGCACCCCTGGCACCT
  TCCTCTCCTCCCACACAGGAAGCTGCCCCACTGGGCAGTGCCCTCAGGCCAGGATCCCCT
  TAGCAGGGTCCTTCCCACCAGACTCAGGGAAGGGATGCCCCATTAAAGTGACAAAAGGGT
  GGGGTGTGGGCACCATGGCATGAGGAAGAAACAAGGTCCCTGAGCAGGCACAAGTCCTGA
  CAGTCAAGGGACTGCTTTGGCATCCAGGGCCTCCAGTCACCTCACTGCCATACATTAGAA
  ATGAGACAATCAAAGCCCCCCCAGGGTGGCACACCCATCCGTTTGCTGGGGTGTGGCAGC
  CACATCCAAGACTGGAGCAGCAGGCTGGCCACGCTCGGGCCAGAGAGAGCTCACAGCTGA
  AGCTCTTGGAGGGAAGGGCTCTCCTCACCCTGCCAGGAAGCTTCTTAACATGTGACAGGA
  CCAGGGACCAGGAGCATGGTGAAGCCAAGTGGCAGATGGGAGCCAACCTGGATGGGGGTT
  TGGGGAAGGAGGGCATGTGTAGCAGAGAACTTAGGGGGGCCTCCTTGCCTTTCTCATTCT
  TTTGCCCTGCATCCTGTCATTTCTGTTCTTGTCCCTCATACATCTTTGGAGAACCGGGCT
  CCAGACTTTGTTCCCTGACTCATAGCTGCCGCTTGTTAGGTTAGGGTTAGATGGGGAGAG
  ACAGGGCACAGAGGACCTGTCTCCCCGGCTACTCTTGCCTTATGGCTCTAGTGTGTGACC
  TACAGAGCATGCTCCACAAGCCCCTGCCTCACCTCACTGTCATCACTAATAAACATCATG
  CACAGTCAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000725 unedited
  AAAACGTTCGNCTTTTGTAATACGACTCACTATAGGCGGCCGCATAACTTCGTATAGCAT
  ACATTATACGAAGTTATGGATCAGGCCAAATCGGCCGAGCTCGAATTCGTCGAGAGCGGG
  TGGGGGGAGCGGTGATCTGAGCTCCGAGCAGCTGGTCTTCGCGGCTCGCTCCCTCCTTCG
  CGCTCTCTCGCTCCCTGCCGCCGCCCGCAGGGCTGCGGGGCTCGGTGGCATCTCCCGGGC
  GCGGCCCGCAGTCCTTGCCCCTGCCTCCGGGCCGCTCCCGCCCCCGGCGCCGCTCGCTCC
  CCCGACCCGGACTCCCCCATGTATGACGACTCCTACGTGCCCGGGTTTGAAGACCTCGGA
  GCAGGTTCAGCCGACTCCTAACCAGCCGGCCATCTCTGGACTCAGACCGTCTCCTTGGNA
  GAGACCGGGAGAGTGCCCCGCGTGGAGTANAGAGCCCAGCTCAACAACAGCTCTGAAAGG
  CCAAGCCACACCTGTGGCATTTGCGGTGAAGACCCATGGCAGCTCCCGTGGCCTTCTTGA
  TGAAGAGTGGCCCAGTCAGGGCTTTGAGTCAACTTTGAGCCCAAGGATTTCTGCCCCTTA
  AGAGGAGTTCAACCATGACTGTGGGATCGGCCGGCTAGTGAAAAAGAGGCGGGGACCATT
  GCCTTNTTCCCCAAACCCAAAAGCCCTGGGAGACTTCGGCTCTCACCCGAGCCCAAGGGC
  CGGGATCTGGGAAACCTTTCCGCCTGGATGAACTTTGGAAACGAAGCTCTCCCTCGCCTT
  TTTTGGCAAGCGAAACCAAAGCCGGCGGGACACGTTCCCCCCTTGAACTGGGGCCCCTCC
  ATTCGGCCTGTGGTGCTCGGGGAACCCTTCCTGAAGGTTTTAAGGGCCAAACCTGGTCCA
  AAGGCCTCTTTG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000725 unedited
  ACCCTATACTTTGNNACCGCGGCCGCATNCTANGATCGACAGNCTTGATATCGGTACCGG
  GCCCCCCCTCGAAGTTCAGGCCCTTATGGCCGGATCCAGCGCTGGAGAGTTTTTTTTTTT
  TTTTTGACTGTGCATGATGTTTATTAGTGATGACAGTGAGGTGAGGCAGGGGCTTGTGGA
  GCATGCTCTGTAGGTCACACACTAGAGCCATAAGGCAAGAGTAGCCGGGGAGACAGGTCC
  TCTGTGCCCTGTCTCTCCCCATCTAACCCTAACCTAACAAGCGGCAGCTATGAGTCAGGG
  AACAAAGTCTGGAGCCCGGTTCTCCAAAGATGTATGAGGGACAAGAACAGAAATGACAGG
  ATGCAGGGCAAAAGAATGAGAAAGGCAAGGAGGCCCCCCTAAGTTCTCTGCTACACATGC
  CCTCCTTCCCCAAACCCCCATCCAGGTTGGCTCCCATCTGCCACTTGGCTTCACCATGCT
  CCTGGTCCCTGGTCCTGTCACATGTTAAGAAGCTTCCTGGCAGGGTGAGGAGAGCCCTTC
  CCTCCAAGAGCTTCAGCTGTGAGCTCTCTCTGGCCCGAGCGTGGCCAGCCTGCTGCTCCA
  GTCTTGGATGTGGCTGCCACACCCCAGCAAACGGATGGGTGTGCCACCCTGGGGGGGCTT
  TGATTGTCTCATTTCTAATGTATGGCAGTGAGGTGACTGGAGGCCCTGGATGCCAAAGCA
  GTCCCTTGACTGTCAGGACTTGTGCCTGCTCAGGGACCTTGTTTCTTTCTCATGCCTTGG
  TGCCCACCCCCCAACCCTTTGGCACTTTTATGGGGGCATCCCCTTCCCTGATTCCGGTGG
  GGAAGAACCCTGCTAAGGTGATCCTGCCCTGAAGGCCCTTCCACTTGGCGCCTCTTCCTG
  TGTGGGC
  
• Restriction Sites: Please inquire
• ACCN: NM_000725
• ORF Size: 1455 bp
• Insert Size: 2700
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: The ORF of this clone has been fully sequenced and found that the protein associated with this clone matches NM_000725 perfectly.

Reference Data

• RefSeq: NM_000725.2, NP_000716.2
• RefSeq Size: 2714
• RefSeq ORF: 1455
• Locus ID: 784
• Domains: Ca_channel_B, GuKc
• Protein Families: Druggable Genome, Ion Channels: Other
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway
• Gene Summary: This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.