Osteoprotegerin (TNFRSF11B) (BC030155) Human Untagged Clone

CAT#: SC122247

TNFRSF11B (untagged)-Human tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) (cDNA clone MGC:29565 IMAGE:4875170), complete cds

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TNFRSF11B
• Synonyms: MGC29565; OCIF; OPG; osteoclastogenesis inhibitory factor; osteoprotegerin; TR1; tumor necrosis factor receptor superfamily, member 11b
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for BC030155 edited
  CTGGAGCTTTCTGCACACCCCCCGACCGCTCCCGCCCAAGCTTCCTAAAAAAGAAAGGTG
  CAAAGTTTGGTCCAGGATAGAAAAATGACTGATCAAAGGCAGGCGATACTTCCTGTTGCC
  GGGACGCTATATATAACGTGATGAGCGCACGGGCTGCGGAGACGCACCGGAGCGCTCGCC
  CAGCCGCCGCCTCCAAGCCCCTGAGGTTTCCGGGGACCACAATGAACAACTTGCTGTGCT
  GCGCGCTCGTGTTTCTGGACATCTCCATTAAGTGGACCACCCAGGAAACGTTTCCTCCAA
  AGTACCTTCATTATGACGAAGAAACCTCTCATCAGCTGTTGTGTGACAAATGTCCTCCTG
  GTACCTACCTAAAACAACACTGTACAGCAAAGTGGAAGACCGTGTGCGCCCCTTGCCCTG
  ACCACTACTACACAGACAGCTGGCACACCAGTGACGAGTGTCTATACTGCAGCCCCGTGT
  GCAAGGAGCTGCAGTACGTCAAGCAGGAGTGCAATCGCACCCACAACCGCGTGTGCGAAT
  GCAAGGAAGGGCGCTACCTTGAGATAGAGTTCTGCTTGAAACATAGGAGCTGCCCTCCTG
  GATTTGGAGTGGTGCAAGCTGGAACCCCAGAGCGAAATACAGTTTGCAAAAGATGTCCAG
  ATGGGTTCTTCTCAAATGAGACGTCATCTAAAGCACCCTGTAGAAAACACACAAATTGCA
  GTGTCTTTGGTCTCCTGCTAACTCAGAAAGGAAATGCAACACACGACAACATATGTTCCG
  GAAACAGTGAATCAACTCAAAAATGTGGAATAGATGTTACCCTGTGTGAGGAGGCATTCT
  TCAGGTTTGCTGTTCCTACAAAGTTTACGCCTAACTGGCTTAGTGTCTTGGTAGACAATT
  TGCCTGGCACCAAAGTAAACGCAGAGAGTGTAGAGAGGATAAAACGGCAACACAGCTCAC
  AAGAACAGACTTTCCAGCTGCTGAAGTTATGGAAACATCAAAACAAAGACCAAGATATAG
  TCAAGAAGATCATCCAAGATATTGACCTCTGTGAAAACAGCGTGCAGCGGCACATTGGAC
  ATGCTAACCTCACCTTCGAGCAGCTTCGTAGCTTGATGGAAAGCTTACCGGGAAAGAAAG
  TGGGAGCAGAAGACATTGAAAAAACAATAAAGGCATGCAAACCCAGTGACCAGATCCTGA
  AGCTGCTCAGTTTGTGGCGAATAAAAAATGGCGACCAAGACACCTTGAAGGGCCTAATGC
  ACGCACTAAAGCACTCAAAGACGTACCACTTTCCCAAAACTGTCACTCAGAGTCTAAAGA
  AGACCATCAGGTTCCTTCACAGCTTCACAATGTACAAATTGTATCAGAAGTTATTTTTAG
  AAATGATAGGTAACCAGGTCCAATCAGTAAAAATAAGCTGCTTATAACTGGAAATGGCCA
  TTGAGCTGTTTCCTCACAATTGGCGAGATCCCATGGATGAGTAAACTGTTTCTCAGGCAC
  TTGAGGCTTTCAGTGATATCTTTCTCATTACCAGTGACTAATTTTGCCACAGGGTACTAA
  AAGAAACTATGATGTGGAGAAAGGACTAACATCTCCTCCAATAAACCCCAAATGGTTAAT
  CCAACTGTCAGATCTGGATCGTTATCTACTGACTATATTTTCCCTTATTACTGCTTGCAG
  TAATTCAACTGGAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for BC030155 unedited
  NAAATGCAGTCATACTTGTAAAAGACTCCTATAGGCGGCCGCGACATTCGCACGAGGCCT
  GGAGCCTTTTCTGCACACCCCCCGACCGCTCCCGCCCAAGCTTCCTAAAAAAAAAGGTGC
  AAAGTTTGGTCCAGGATAGAAAAATGACTGATCAAAGGCAGGCGATACTTCCTGTTGCCG
  GGACGCTATATATAACGTGATGAGCGCACGGGCTGCGGAGACGCACCGGAGCGCTCGCCC
  AGCCGCCGCCTCCAAGCCCCTGAGGTTTCCGGGGACCACAATGAACAACTTGCTGTGCTG
  CGCGCTCGTGTTTCTGGACATCTCCATTAAGTGGACCACCCAGGAAACGTTTCCTCCAAA
  GTACCTTCATTATGACGAAGAAACCTCTCATCAGCTGTTGTGTGACAAATGTCCTCCTGG
  TACCTACCTAAAACAACACTGTACAGCAAAGTGGAAGACCGTGTGCGCCCCTTGCCCTGA
  CCACTACTACACAGACAGCTGGCACACCAGTGACGAGTGTCTATACTGCAGCCCCGTGTG
  CAAGGAGCTGCAGTACGTCAAGCAGGAGTGCAATCGCACCCACAACCGCGTGTGCGAATG
  CAAGGAAGGGCGCTACCTTGAGATAGAGTTCTGCTTGAAACATAGGAGCTGCCCTCCTGG
  ATTTGGAGTGGTGCAAGCTGGAACCCCAGAGCGAAATACAGTTTGCANAAGATGTCCAGA
  TGGGTTCTTCTCAAATGAGACGTCATCTAAAGCACCCTGTAGAAAACACACAAATTGCAG
  TGTCTTTGGTCTCCTGCTAACTCAGAAAGGAATGCAACACACGACACATATGTTTCCGNA
  ACAGTGAATCAACTCAA
  
• Restriction Sites: Please inquire
• ACCN: BC030155
• Insert Size: 1700 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC030155.2, AAH30155.1
• RefSeq Size: 1710 bp
• Locus ID: 4982
• Cytogenetics: 8q24.12
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction
• Gene Summary: 'The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]'