IL1RA (IL1RN) (NM_000577) Human Untagged Clone

CAT#: SC122567

IL1RN (untagged)-Human interleukin 1 receptor antagonist (IL1RN), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IL1RN
• Synonyms: DIRA; ICIL-1RA; IL-1ra; IL-1ra3; IL-1RN; IL1F3; IL1RA; IRAP; MVCD4
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_000577 edited
  GGAAGACCTCCTGTCCTATCAGGCCCTCCCCATGGCTTTAGAGACGATCTGCCGACCCTC
  TGGGAGAAAATCCAGCAAGATGCAAGCCTTCAGAATCTGGGATGTTAACCAGAAGACCTT
  CTATCTGAGGAACAACCAACTAGTTGCCGGATACTTGCAAGGACCAAATGTCAATTTAGA
  AGAAAAGATAGATGTGGTACCCATTGAGCCTCATGCTCTGTTCTTGGGAATCCATGGAGG
  GAAGATGTGCCTGTCCTGTGTCAAGTCTGGTGATGAGACCAGACTCCAGCTGGAGGCAGT
  TAACATCACTGACCTGAGCGAGAACAGAAAGCAGGACAAGCGCTTCGCCTTCATCCGCTC
  AGACAGTGGCCCCACCACCAGTTTTGAGTCTGCCGCCTGCCCCGGTTGGTTCCTCTGCAC
  AGCGATGGAAGCTGACCAGCCCGTCAGCCTCACCAATATGCCTGACGAAGGCGTCATGGT
  CACCAAATTCTACTTCCAGGAGGACGAGTAGTACTGCCCAGGCCTGCCTGTTCCCATTCT
  TGCATGGCAAGGACTGCAGGGACTGCCAGTCCCCCTGCCCCAGGGCTCCCGGCTATGGGG
  GCACTGAGGACCAGCCATTGAGGGGTGGACCCTCAGAAGGCGTCACAACAACCTGGTCAC
  AGGACTCTGCCTCCTCTTCAACTGACCAGCCTCCATGCTGCCTCCAGAATGGTCTTTCTA
  ATGTGTGAATCAGAGCACAGCAGCCCCTGCACAAAGCCCTTCCATGTCGCCTCTGCATTC
  AGGATCAAACCCCGACCACCTGCCCAACCTGCTCTCCTCTTGCCACTGCCTCTTCCTCCC
  TCATTCCACCTTCCCATGCCCTGGATCCATCAGGCCACTTGATGACCCCCAACCAAGTGG
  CTCCCACACCCTGTTTTACAAAAAAGAAAAGACCAGTCCATGAGGGAGGTTTTTAAGGGT
  TTGTGGAAAATGAAAATTAGGATTTCATGATTTTTTTTTTTCAGTCCCCGTGAAGGAGAG
  CCCTTCATTTGGAGATTATGTTCTTTCGGGGAGAGGCTGAGGACTTAAAATATTCCTGCA
  TTTGTGAAATGATGGTGAAAGTAAGTGGTAGCTTTTCCCTTCTTTTTCTTCTTTTTTTGT
  GATGTCCCAACTTGTAAAAATTAAAAGTTATGGTACTATGTTAGCCCCATAATTTTTTTT
  TTCCTTTTAAAACACTTCCATAATCTGGACTCCTCTGTCCAGGCACTGCTGCCCAGCCTC
  CAAGCTCCATCTCCACTCCAGATTTTTTACAGCTGCCTGCAGTACTTTACCTCCTATCAG
  AAGTTTCTCAGCTCCCAAGGCTCTGAGCAAATGTGGCTCCTGGGGGTTCTTTCTTCCTCT
  GCTGAAGGAATAAATTGCTCCTTGACATTGTAGAGCTTCTGGCACTTGGAGACTTGTATG
  AAAGATGGCTGTGCCTCTGCCTGTCTCCCCCACCAGGCTGGGAGCTCTGCAGAGCAGGAA
  ACATGACTCGTATATGTCTCAGGTCCCTGCAGGGCCAAGCACCTAGCCTCGCTCTTGGCA
  GGTACTCAGCGAATGAATGCTGTATATGTTGGGTGCAAAGTTCCCTACTTCCTGTGACTT
  CAGCTCTGTTTTACAATAAAATCTTGAAAATGCCTAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000577 unedited
  ATAGCGTTCGCTTTTGTATACGACTCATTTAGGGCGGCCGCGTAATTCGCACGAGGGGGA
  ANACCTCCTGTCCTATCAGGCCCTCCCCTGGCTTTAGAGACGATCTGCCGACCCTCTGGG
  CAGAAAATCCAGCAAGATGCAAGCCTTCATAATCTGGGATGTTAACCAGAAGACCTTCTA
  TCTGAGGAACAACCAACTAGTTGCCGGATACTTGCAAGGACCAAATGTCAATTTAGAAGA
  AAAGATAGATGTGGTACCCATTGAGCCTCATGCTCTGTTCTTGGGAATCCATGGAGGGAA
  GATGTGCCTGTCCTGTGTCAAGTCTGGTGATGAGACCAGACTCCAGCTGGAGGCAGTTAA
  CATCACTGACCTGAGCGAGAACAGAAAGCAGGACAAGCGCTTCGCCTTCATCCGCTCAGA
  CAGTGGCCCCACCACCAGTTTTGAGTCTGCCGCCTGCCCCGGTTGGTTCCTCTGCACAGC
  GATGGAAGCTGACCAGCCCGTCAGCCTCACCAATATGCCTGACGAATGCGTCATGGTCAC
  CAAATTCTACTTCCAGGAGGACGAGTAGTACTGCCCAGGCCTGCCTGTTCCCATTCTTGC
  ATGGCAAGGACTGCAGGGACTGCCAGTCCCCCTGCCCCAGGGCTCCCGGCTATGGGGGCA
  CTGAGGACCCGCCATTGAGGGGTGGACCCTCAGAAGGCGTCACAACAACCTGGTCACAGG
  ACTCTGCCTCCCCTTCAACTGACCAGCCTCCTTGCTGCCTACAGAATGGTCTTTCTAATG
  TGTGAATCACACCCAGCATCCCCTTGAAAAGGCCTTTCCAGGTCGCTTTGGCTTTATGAT
  CAAACCCCGGACCACTGGCCAACCGCTTTTCTCTTGGCATTGGCCCTTCCTTCCCTCATC
  CGACCTGGCAG
  
• Restriction Sites: Please inquire
• ACCN: NM_000577
• Insert Size: 1716 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000577.3, NP_000568.1
• RefSeq Size: 1802 bp
• RefSeq ORF: 480 bp
• Locus ID: 3557
• Cytogenetics: 2q14.1
• Protein Families: Druggable Genome, Secreted Protein
• Gene Summary: 'The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]'
  Transcript Variant: This variant (3) lacks an inframe coding segment, as compared to variant 2. The resulting isoform (3) lacks an internal region, as compared to the longest isoform (2).