LEFTY2 (NM_003240) Human Untagged Clone

CAT#: SC122648

LEFTY2 (untagged)-Human left-right determination factor 2 (LEFTY2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LEFTY2
• Synonyms: EBAF; LEFTA; LEFTYA; TGFB4
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003240 edited
  CTGAGACCCTCCTTCAACCTCCCTAGAGGACAGCCCCACTCTGCCTCCTGCTCCCCCAGG
  GCAGCACCATGTGGCCCCTGTGGCTCTGCTGGGCACTCTGGGTGCTGCCCCTGGCTGGCC
  CCGGGGCGGCCCTGACCGAGGAGCAGCTCCTGGGCAGCCTGCTGCGGCAGCTGCAGCTCA
  GCGAGGTGCCCGTACTGGACAGGGCCGACATGGAGAAGCTGGTCATCCCCGCCCACGTGA
  GGGCCCAGTATGTAGTCCTGCTGCGGCGCAGCCACGGGGACCGCTCCCGCGGAAAGAGGT
  TCAGCCAGAGCTTCCGAGAGGTGGCCGGCAGGTTCCTGGCGTCGGAGGCCAGCACACACC
  TGCTGGTGTTCGGCATGGAGCAGCGGCTGCCGCCCAACAGCGAGCTGGTGCAGGCCGTGC
  TGCGGCTCTTCCAGGAGCCGGTCCCCAAGGCCGCGCTGCACAGGCACGGGCGGCTGTCCC
  CGCGCAGCGCCCAGGCCCGGGTGACCGTCGAGTGGCTGCGCGTCCGCGACGACGGCTCCA
  ACCGCACCTCCCTCATCGACTCCAGGCTGGTGTCCGTCCACGAGAGCGGCTGGAAGGCCT
  TCGACGTGACCGAGGCCGTGAACTTCTGGCAGCAGCTGAGCCGGCCCCGGCAGCCGCTGC
  TGCTACAGGTGTCGGTGCAGAGGGAGCATCTGGGCCCGCTGGCGTCCGGCGCCCACAAGC
  TGGTCCGCTTTGCCTCGCAGGGGGCGCCAGCCGGGCTTGGGGAGCCCCAGCTGGAGCTGC
  ACACCCTGGACCTCAGGGACTATGGAGCTCAGGGCGACTGTGACCCTGAAGCACCAATGA
  CCGAGGGCACCCGCTGCTGCCGCCAGGAGATGTACATTGACCTGCAGGGGATGAAGTGGG
  CCAAGAACTGGGTGCTGGAGCCCCCGGGCTTCCTGGCTTACGAGTGTGTGGGCACCTGCC
  AGCAGCCCCCGGAGGCCCTGGCCTTCAATTGGCCATTTCTGGGGCCGCGACAGTGTATCG
  CCTCGGAGACTGCCTCGCTGCCCATGATCGTCAGCATCAAGGAGGGAGGCAGGACCAGGC
  CCCAGGTGGTCAGCCTGCCCAACATGAGGGTGCAGAAGTGCAGCTGTGCCTCGGATGGGG
  CGCTCGTGCCAAGGAGGCTCCAGCCATAGGCGCCTGGTGTATCCATTGAGCCCTCTAACT
  GAACGTGTGCATAGAGGTGGTCTTAATGTAGGTCTTAACTTTATACTTAGCAAGTTACTC
  CATCCCAATTTAGTGCTCCTGTGTGACCTTCGCCCTGTGTCCTTCCATTTCCTGTCTTTC
  CCGTCCATCACCCATCCTAAGCACTTACGTGAGTAAATAATGCAGCTCAGATGCTGAGCT
  CTAGTAGGAAATGCTGGCATGCTGATTACAAGATACAGCTGAGCAATGCACACATTTTCA
  GCTGGGAGTTTCTGTTCTCTGGCAAATTCTTCACTGAGTCTGGAACAATAATACCCTATG
  ATTAGAACTGGGGAAACAGAACTGAATTGCTGTGTTATATGAGGAATTAAAACCTTCAAA
  TCTCTATTTCCCCCAAATACTGACCCATTCTGGACTTTTGTAAACATACCTAGGCCCCTG
  TTCCCCTGAGAGGGTGCTAAGAGGAAGGATGAAGGGCTTCAGGCTGGGGGCAGTGGACAG
  GGAATTGGGATACCTGGATTCTGGTTCTGACAGGGCCACAAGCTAGGATCTCTAACAAAC
  GCAGAAGGCTTTGGCTCGTCATTTCCTCTTAAAAAGGAGGAGCTGGGCTTCAGCTCTAAG
  AACTTCATTGCCCTGGGGATCAGACAGCCCCTACCTACCCCTGCCCACTCCTCTGGAGAC
  TGAGCCTTGCCCGTGCATATTTAGGTCATTTCCCACACTGTCTTAGAGAACTTGTCACCA
  GAAACCACATGTATTTGCATGTTTTTTGTTAATTTAGCTAAAGCAATTGAATGTAGATAC
  TCAGAAGAAATAAAAAATGATGTTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003240 unedited
  GGGNNCGGCCGCGCAATTCCCGGGATCTGAGACCCTCCTTCAACCTCCCTAGAGACAGCC
  CCACTCTGCCTCCTGCTCCCCCAGGGCAGCACCATGTGGCCCCTGTGGCTCTGCTGGGCA
  CTCTGGGTGCTGCCCCTGGCTGGCCCCGGGGCGGCCCTGACCGAGGAGCAGCTCCTGGGC
  AGCCTGCTGCGGCAGCTGCAGCTCAGCGAGGTGCCCGTACTGGACAGGGCCGACATGGAG
  AAGCTGGTCATCCCCGCCCACGTGAGGGCCCAGTATGTAGTCCTGCTGCGGCGCAGCCAC
  GGGGACCGCTCCCGCGGAAAGAGGTTCAGCCAGAGCTTCCGAGAGGTGGCCGGCAGGTTC
  CTGGCGTCGGAGGCCAGCACACACCTGCTGGTGTTCGGCATGGAGCAGCGGCTGCCGCCC
  AACAGCGAGCTGGTGCAGGCCGTGCTGCGGCTCTTCCAGGAGCCGGTCCCCAAGGCCGCG
  CTGCACAGGCACGGGCGGCTGTCCCCGCGCAGCGCCCAGGCCCGGGTGACCGTCGAGTGG
  CTGCGCGTCCGCGACGACGGCTCCAACCGCACCTCCCTCATCGACTCCAGGCTGGTGTCC
  GTCCACGAGAGCGGCTGGGAAGCCTTCGACGTGACCGAGGCCGTGAACTTCTGGCAGCAA
  CTGAGCCCGCCCCGGCAGCCGCTGCTGCTACAGGTGTCGGTGCAGAGGGAGCATCTGGGC
  CCGCTGGCGTCCGGCGCCCACAAGCTGGTCCGCTTTGGCCTCGCAAGGGGCGCCAGCCGG
  GGCTTGGGGAGCCCCAACTGGAGCTGCACACCCTGGACCTCAGGGACTATGGG
  
• Restriction Sites: Please inquire
• ACCN: NM_003240
• Insert Size: 2090 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_003240.2, NP_003231.2
• RefSeq Size: 2102 bp
• RefSeq ORF: 1101 bp
• Locus ID: 7044
• Cytogenetics: 1q42.12
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: TGF-beta signaling pathway
• Gene Summary: 'This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]'
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).