Oligodendrocyte Specific Protein (CLDN11) (NM_005602) Human Untagged Clone

CAT#: SC122723

CLDN11 (untagged)-Human claudin 11 (CLDN11), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CLDN11
• Synonyms: OSP; OTM
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_005602 edited
  GTCCCCGCCGTGCGCCCTTCGCCGCTGAGCTCGCAGCCTCCGGCGCCCACCTCCACCTCC
  AGTGTCCCGCCTCGGGCCGTCGCCCTCCAGCGGCTCGCGAGCGTGGGAGACGTACCTGGG
  CAGGCACTGTCCAGCCCAGGCCCAGGCACAGCCGTGAGGGGCGAGGCACGGGGACATCCT
  GGCGGCCACCATGGTGGCCACGTGCCTGCAGGTGGTGGGCTTCGTCACGAGCTTCGTGGG
  CTGGATCGGGGTCATCGTGACCACCTCCACCAATGACTGGGTGGTGACCTGCGGCTACAC
  CATCCCCACCTGCCGCAAGCTGGATGAGCTGGGCTCCAAGGGGCTGTGGGCCGACTGCGT
  CATGGCCACGGGGCTGTACCACTGCAAGCCCCTGGTGGACATCCTCATCCTGCCGGGCTA
  CGTGCAGGCCTGCCGCGCCCTGATGATTGCTGCCTCGGTCCTGGGTCTGCCGGCCATTTT
  ACTGCTGCTGACTGTTCTTCCCTGCATCCGGATGGGCCAGGAGCCCGGTGTGGCTAAGTA
  CAGGCGGGCCCAGCTGGCTGGTGTTTTGCTCATTCTGCTGGCTCTCTGCGCCCTTGTTGC
  CACCATCTGGTTCCCTGTGTGCGCCCACCGTGAGACCACCATCGTGAGCTTTGGCTACTC
  CCTGTATGCAGGCTGGATTGGTGCTGTGCTGTGCCTCGTGGGTGGCTGTGTCATCCTCTG
  CTGCGCTGGAGATGCCCAGGCCTTTGGTGAAAACCGTTTCTACTACACTGCGGGCTCTAG
  CTCCCCGACTCATGCGAAGAGTGCCCACGTATAAGAGGGCTGCCCGGCTGCCCACAGAGG
  TGCTGTAGATGCTGGGCCCAGGGCCCTAGGTTTGCTCGTCACAGTGTGGGGAAGCCCATT
  CCTCTGCCAGGCTCTAAAGCCAAAGGTCTAGAAAAGCATCCTGTCTGGCATTTTGTAGTC
  TTAACTTCTCCCCATTTCCCCCATCTTTTGGTTGCCTTAAAAGAAATCTCTAGCTCAGAT
  AATGCCCAGACATTTTTTTCCCTTGGTGTTGCCCCTATTAGCTCTTTTCTTGGGCATTCT
  TCTGCTGTTTATTAAAAATATATTATATATATTTTGTTTCTTTAAATTTCAAATGTTTTG
  CAAACATCACTGAGTTAGGTGGGGGTGGGGAAGAGAAATACAAGATACTTTTTTTTTTTT
  TTTTTTAAATAGGGCCTCACTCTGTTGCTCAGGCTGGAGTGCGGTGGTGTGATCTCGGCT
  CATGTAGCCTCAACCTCCCCGGCTCAAGTGATCCTCCTGCCTCAGCCTCCCAAGTAGCTG
  GGACTACAGGCGTTCACTACTACACCCAGCTAATTTTTAAGTTTTTTATAGAGATGAGGG
  CTCCCTATGTTGCCCAGGTTGGTCTCGAACTCCTGGACTCAAAGTATCCTCCCGCCTCGG
  CCTCCCAAAGTGTTGGGATTATAGGAGTGAGCCACCACACCAGCCAAGATGCTTTTCAAA
  CTGATACAGATGACAATGGGAGCCTCATAAAGATGGCTTTTGTTTCTTCCCTTCAAGGTC
  ATTTACTTGTACGAGACAGAAAAAGATAGCATTGGGGACATGGGATGGGGGAGGGAGGGC
  AATAGTGGAACGAACTTTCCATGGGAAACTTTCCCTTTTGTAAGTTGAGGGCCAGGGGTA
  GGGATATTTTTTAGTTTGTGATTTTACATTTATCTGTACATACTTTTTCAAGATTGATCA
  TTTTTATAACCATGGTTTTCCTGAAATCCTCAATTCATCAATATGAAGGAAATGAACCAC
  ATAGACTTTATGCAATAAATAACAGTGCAAGTGAGTATAACTCTAACTGATGTTCCACAA
  AACATTTTTGATTTCAGGTTTGTATGATGTAGTTTTTAATCGTACATTTTCATATGCTTC
  AAACTAACACATTTTTAAAGCTTTCCCCCACTTTTCTCTCTATTTGTATTGTTAGCCATC
  TTGAAGTGATGTTGTTTAACATAAATTGTACTGTTGAATTTGGCTTTACGGGTGTAAACA
  CTGATGGTATATCAGTATCTGAGACCCCAAACTCTCCAAATACTGATGGTGCATTTTATT
  CTTGAAGTGAAATCTGTGCAATAAAATAACAGACTGTCTGCAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005602 unedited
  NNNNTTGTTCGGATTTGTATACGACTCATATAGGGCGGCCGCGATTCCCGGGATATCGTC
  GACCCACGCGTCCGGTCCCCGCCGTGCGCCCTTCGCCGCTGAGCTCGCAGCCTCCGGCGC
  CCACCTCCACCTCCAGTGTCCCGCCTCGGGCCGTCGCCCTCCAGCGGCTCGCGAGCGTGG
  GAGACGTACCTGGGCAGGCACTGTCCAGCCCAGGCCCAGGCACAGCCGTGAGGGGCGAGG
  CACGGGGACATCCTGGCGGCCACCATGGTGGCCACGTGCCTGCAGGTGGTGGGCTTCGTC
  ACGAGCTTCGTGGGCTGGATCGGGGTCATCGTGACCACCTCCACCAATGACTGGGTGGTG
  ACCTGCGGCTACACCATCCCCACCTGCCGCAAGCTGGATGAGCTGGGCTCCAAGGGGCTG
  TGGGCCGACTGCGTCATGGCCACGGNGCTGTACCACTGCAAGCCCCTGGTGGACATCCTC
  ATCCTGCCGGGCTACGTGCAGGCCTGCCGCGCCCTGATGATTGCTGCCTCGGTCCTGGGT
  CTGCCGGCCATTTTACTGCTGCTGACTGTTCTTCCCTGCATCCGGATGGGCCAGGAGCCC
  GGTGTGGCTAAGTACAGGCGGGCCCAGCTGGCTGGTGTTTTGCTCATTCTGCTGGCTCTC
  TGCGCCCTTGTTGCCACCATCTGGTTCCCTGTGTGCGCCCACCGTGAGACCACCATCGTG
  AGCTTTGGCTACTCCNTGTATGCANGCTGGATTGGTGCTGTGCTGTGCCTCGTGGGGTGC
  TGTGTCATCCTCTGCTGCGCTGGAGATGCCCCAGCCTTTGGTGAAACCCGTTCTACTACA
  CTGCGGGCTCTAGCTTCCCGACTCATGCGAAGAGTGCCCACC
  
• Restriction Sites: Please inquire
• ACCN: NM_005602
• Insert Size: 2156 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_005602.4, NP_005593.2
• RefSeq Size: 2169 bp
• RefSeq ORF: 624 bp
• Locus ID: 5010
• Cytogenetics: 3q26.2
• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction
• Gene Summary: 'This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]'
  Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).