IKZF3 (NM_012481) Human Untagged Clone

CAT#: SC122788

IKZF3 (untagged)-Human IKAROS family zinc finger 3 (Aiolos) (IKZF3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IKZF3
• Synonyms: AIO; AIOLOS; ZNFN1A3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_012481 edited
  CCACGCGTCCGGGTAGCCACAGCGGCAGCTCCAGCCCGGCCCGGCAGCGACATGGAAGAT
  ATACAAACAAATGCGGAACTGAAAAGCACTCAGGAGCAGTCTGTGCCCGCAGAAAGTGCA
  GCGGTTTTGAATGACTACAGTTTAACCAAATCTCATGAAATGGAAAATGTGGACAGTGGA
  GAAGGCCCAGCCAATGAAGATGAAGACATAGGAGATGATTCAATGAAAGTGAAAGATGAA
  TACAGTGAAAGAGATGAGAATGTTTTAAAGTCAGAACCCATGGGAAATGCAGAAGAGCCT
  GAAATCCCTTACAGCTATTCAAGAGAATATAATGAATATGAAAACATTAAGTTGGAGAGA
  CATGTTGTCTCATTCGATAGTAGCAGGCCAACCAGTGGAAAGATGAACTGCGATGTGTGT
  GGATTATCCTGCATCAGCTTCAATGTCTTAATGGTTCATAAGCGAAGCCATACTGGTGAA
  CGCCCATTCCAGTGTAATCAGTGTGGGGCATCTTTTACTCAGAAAGGTAACCTCCTCCGC
  CACATTAAACTGCACACAGGGGAAAAACCTTTTAAGTGTCACCTCTGCAACTATGCATGC
  CAAAGAAGAGATGCGCTCACGGGGCATCTTAGGACACATTCTGTGGAGAAACCCTACAAA
  TGTGAGTTTTGTGGAAGGAGTTACAAGCAGAGAAGTTCCCTTGAGGAGCACAAGGAGCGC
  TGCCGTACATTTCTTCAGAGCACTGACCCAGGGGACACTGCAAGTGCGGAGGCAAGACAC
  ATCAAAGCAGAGATGGGAAGTGAAAGAGCTCTCGTACTGGACAGATTAGCAAGCAATGTG
  GCAAAACGAAAAAGCTCAATGCCTCAGAAATTCATTGGTGAGAAGCGCCACTGCTTTGAT
  GTCAACTATAATTCAAGTTACATGTATGAGAAAGAGAGTGAGCTCATACAGACCCGCATG
  ATGGACCAAGCCATCAATAACGCCATCAGCTATCTTGGCGCCGAAGCCCTGCGCCCCTTG
  GTCCAGACACCGCCTGCTCCCACCTCGGAGATGGTTCCAGTTATCAGCAGCATGTATCCC
  ATAGCCCTCACCCGGGCTGAGATGTCAAACGGTGCCCCTCAAGAGCTGGAAAAGAAAAGC
  ATCCACCTTCCAGAGAAGAGCGTGCCTTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGC
  CACGACTCCACGGACACTGACAGCAACCATGAAGAACGCCAGAATCACATCTATCAGCAA
  AATCACATGGTCCTGTCTCGGGCCCGCAATGGGATGCCACTTCTGAAGGAGGTTCCCCGC
  TCTTACGAACTCCTCAAGCCCCCGCCCATCTGCCCAAGAGACTCCGTCAAAGTGATCAAC
  AAGGAAGGGGAGGTGATGGATGTGTATCGGTGTGACCACTGCCGCGTCCTCTTCCTGGAC
  TATGTGATGTTCACGATTCACATGGGCTGCCACGGCTTCCGTGACCCTTTCGAGTGTAAC
  ATGTGTGGATATCGAAGCCATGATCGGTATGAGTTCTCGTCTCACATAGCCAGAGGAGAA
  CACAGAGCCCTGCTGAAGTGAATATCTGGTCTCAGGGATTGCTCCTATGTATTCAGCATC
  GTTTCTAAAAACCAATGACCTCGCCTAACAGATTGCTCTCAAAACATACTCAGTTCCAAA
  CTTCTTTTCATACCATTTTTAGCTGTGTTCACAGGGGTAGCCAGAGAAACACTGTCTTCC
  TTCAGAAATTATTCGCAGGTCTAGCATATTATTACTTTTGTGAAACCTTTGTTTTCCCAT
  CAGGGACTTGAATTTTATGGAATTTAAAAGCCAAAAAGGTATTTGGTCATTATCTTCTAC
  AGCAGTGGAATGAGTGGTCCCGGAGATGTGCTATATGAAACATTCTTTCTGAGATATATC
  AACCACACGTGGAAAAGCCTTTCAGTCATACATGCAAATCCACAAAGAGGAAGAGCTGAC
  CAGCTGACCTTGCTGGGAAGCCTCACCCTTCTGCCCTTCACAGGCTGAAGGGTTAAGATC
  TAATCTCCCTAATCTAAATGACAGTCTAAGAGTAAGTAAAAGAACAGCCATAAAATAAGT
  ATCTGTTACGAGTAACTGAAGACCCCATTCTCCAAGCATCAGATCCATTTCCTATCACAA
  CATTTTTAAAAAATGTCATCTGATGGCACTTCTGCTTCTGTCCTTTACCTTCCCATCTCC
  AGTGAAAAGCTGAGCTGCTTTGGGCTAAACCAGTTGTCTATAGAAGAAAATCTATGCCAG
  AAGAACTCATGGTTTTAAATATAGACCATCATCGAAACTCCAGAAATTTATCCACTGTGG
  ATGATGACATCGCTTTCCTTTGGTCAAGGTTGGCAGAGCAAGGGTATAAAGGGGGAAATT
  GTTTGGCAGCACCAACAGAAAACAAAACAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_012481 unedited
  CTTAGCATTAGTAATACGACTTTATATNAGGGCGGCACGCGGAATTCCCGGGGAATCGTC
  GACCCACGCGTCCGGGTAGCCACAGCGGCAGCTCCAGCCCGGCCCGGCAGCGACATGGGA
  AGATATACAAACAAATGCGGAACTGAAAAGCACTCAGGAGCAGTCTGTGCCCGCAGAAAG
  TGCAGCGGTTTTGAATGACTACAGTTTAACCAAATCTCATGAAATGGAAAATGTGGACAG
  TGGAGAAGGCCCAGCCAATGAAGATGAAGACATAGGAGATGATTCAATGAAAGTGAAAGA
  TGAATACAGTGAAAGAGATGAGAATGTTTTAAAGTCAGAACCCATGGGAAATGCAGAAGA
  GCCTGAAATCCCTTACAGCTATTCAAGAGAATATAATGAATATGAAAACATTAAGTTGGA
  GAGACATGTTGTCTCATTCGATAGTAGCAGGCCAACCAGTGGAAAGATGAACTGCGATGT
  GTGTGGATTATCCTGCATCAGCTTCAATGTCTTAATGGTTCATAAGCGAAGCCATACTGG
  TGAACGCCCATTCCAGTGTAATCAGTGTGGAGCATCTTTTACTCAGAAAGGTAACCTCCT
  CCGCCACATTAAACTGCACACAGGGGGAAAAACCTTTTAAGTGTCACCCTCTGCACTATG
  CATGCCANAGAAGAGATGCCCTTACGGGGCATCTTTAGGACACATTCTGTGGAAAAAACC
  CTACAAATGTGAAGTTTTTGGGGAAGGAGTTTACAAGCCAAAAAATTTCCCTTGAAGAAC
  ACAAGGGACGCCTGCCGTACATTTCTTTCGGAACACTGACCCAAGGGACACCTGCAGTGC
  GGGAGGCAAACAACCTCCAATCCAAATTGGGAAGGGAAAAAGCTCTCGTATCGGACAAAT
  TAACAGCCATGGGGCAAAACAAAAAATCCATGGCTGCGAAATTCTT
  
• Restriction Sites: Please inquire
• ACCN: NM_012481
• ORF Size: 1530 bp
• Insert Size: 2443
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_012481.3, NP_036613.2
• RefSeq Size: 2437
• RefSeq ORF: 1530
• Locus ID: 22806
• Gene Summary: This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
  Transcript Variant: This variant (1) encodes the longest isoform (1, also known as Aio-1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.