APEX2 (NM_014481) Human Untagged Clone

CAT#: SC122813

APEX2 (untagged)-Human APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2), nuclear gene encoding mitochondrial protein

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: APEX2
• Synonyms: APE2; APEXL2; XTH2; ZGRF2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_014481 edited
  AGGTTGGCGCGGGCTGGGAGGTGTTCCAGCCCTTTAAGATGTTGCGCGTGGTGAGCTGGA
  ACATCAATGGGATTCGGAGACCCCTGCAAGGGGTGGCAAATCAGGAACCCAGCAACTGTG
  CCGCCGTGGCCGTGGGGCGCATTTTGGACGAGCTGGATGCGGATATCGTCTGTCTCCAGG
  AAACCAAAGTGACCAGGGATGCACTGACAGAGCCCCTGGCTATCGTTGAGGGTTATAACT
  CCTATTTCAGCTTCAGCCGCAACCGTAGCGGCTATTCTGGTGTAGCCACCTTCTGTAAGG
  ACAATGCTACCCCAGTGGCTGCTGAAGAAGGCCTGAGTGGCCTGTTTGCCACCCAGAATG
  GGGATGTTGGTTGCTATGGAAACATGGATGAGTTTACCCAAGAGGAACTCCGGGCTCTGG
  ATAGTGAGGGCAGGGCCCTCCTCACACAGCATAAGATCCGCACATGGGAAGGTAAGGAGA
  AGACCTTGACCCTAATCAACGTGTACTGCCCCCATGCGGACCCTGGGAGGCCTGAGCGGC
  TAGTCTTTAAGATGCGCTTCTATCGTTTGCTGCAAATCCGAGCAGAAGCCCTCCTGGCGG
  CAGGCAGCCATGTGATCATTCTGGGTGACCTGAATACAGCCCACCGCCCCATTGACCACT
  GGGATGCAGTCAACCTGGAATGCTTTGAAGAGGACCCAGGGCGCAAGTGGATGGACAGCT
  TGCTCAGTAACTTGGGGTGCCAGTCTGCCTCTCATGTAGGGCCCTTCATCGATAGCTACC
  GCTGCTTCCAACCAAAGCAGGAGGGGGCCTTCACCTGCTGGTCAGCAGTCACTGGCGCCC
  GCCATCTCAACTATGGCTCCCGGCTTGACTATGTGCTGGGGGACAGGACCCTGGTCATAG
  ACACCTTTCAGGCCTCTTTCCTGCTGCCTGAGGTGATGGGCTCTGACCACTGCCCTGTGG
  GTGCAGTCTTGAGTGTGTCCTCTGTGCCTGCAAAACAGTGCCCACCTCTGTGCACCCGCT
  TCCTCCCTGAGTTTGCAGGCACCCAGCTCAAGATCCTTCGCTTCCTAGTTCCTCTCGAAC
  AAAGTCCTGTGTTGGAGCAGTCGACGCTGCAGCACAACAATCAAACCCGGGTACAGACAT
  GCCAAAACAAAGCCCAAGTGCGCTCAACCAGGCCTCAGCCCAGTCAGGTTGGCTCTAGCA
  GAGGCCAGAAAAACCTGAAGAGCTACTTTCAGCCCTCCCCTAGCTGTCCCCAAGCCTCTC
  CTGACATAGAGCTGCCTAGCCTACCACTGATGAGCGCCCTCATGACCCCGAAGACTCCAG
  AAGAGAAGGCAGTGGCCAAAGTGGTGAAGGGGCAGGCCAAGACTTCAGAAGCCAAAGATG
  AGAAGGAGTTACGGACCTCATTCTGGAAGTCTGTGCTGGCGGGGCCCTTGCGCACACCCC
  TCTGTGGGGGCCACAGGGAGCCATGTGTGATGCGTACTGTGAAGAAGCCAGGACCCAACT
  TGGGCCGCCGCTTCTACATGTGTGCCAGGCCCCGGGGTCCTCCCACTGACCCCTCCTCCC
  GGTGCAACTTCTTCCTCTGGAGCAGGCCCAGCTGAACCAATGGAGGCCTGGGGACATCTG
  GCATGGTCACCCCTGCACATGATCTGAGGCCAGCTCCCCTTCCCTGAGCTGCCTCCTGCT
  TCTCCCTCAAAGTCTCCTACCCTTCTCTTCCTCTTTTAAGCCCTCTCTTCCTCGCTTTCC
  TTCCTACCTAGCTCCTTGTTGGTGAGCTTCTTGTGCCTTAATCCTGTGACCCAGCCCCTT
  ACACCACTTTCCACCTTCCTGTCCGAAGTACACGGACACTAGCTGCCCCAGGAAGTTGTG
  TGATTTTAAATCACTTCTGTCTTTGCTGGAAAGTGTATTTGTGCATAAATAAAGTCTGTG
  TATTTGTTTCAAAAAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014481 unedited
  NAACGTCGAAATTGTAAACGCCTCCTATAGGCGGCCGCGACATTCGCACGAGGAGGTTGG
  CGCGGGCTGGGAGGTGTTCCAGCCCTTTAAGAGTTGCGCGTGGTGAGCTGGAACATCAAT
  GGGATTCGGAGACCCCTGCAAGGGGTGGCAAATCAGGAACCCAGCAACTGTGCCGCCGTG
  GCCGTGGGGCGCATTTTGGACGAGCTGGATGCGGATATCGTCTGTCTCCAGGAAACCAAA
  GTGACCAGGGATGCACTGACAGAGCCCCTGGCTATCGTTGAGGGTTATAACTCCTATTTC
  AGCTTCAGCCGCAACCGTAGCGGCTATTCTGGTGTAGCCACCTTCTGTAAGGACAATGCT
  ACCCCAGTGGCTGCTGAAGAAGGCCTGAGTGGCCTGTTTGCCACCCAGAATGGGGATGTT
  GGTTGCTATGGAAACATGGATGAGTTTACCCAAGAGGAACTCCGGGCTCTGGATAGTGAG
  GGCAGGGCCCTCCTCACACAGCATAAGATCCGCACATGGGAAGGTAAGGAGAAGACCTTG
  ACCCTAATCAACGTGTACTGCCCCCATGCGGACCCTGGGAGGCCTGAGCGGCTAGTCTTT
  AAGATGCGCTTCTATCGTTTGCTGCAAATCCGAGCAGAAGCCCTCCTGGCGGCAGGCAGC
  CATGTGATCATTCTGGGTGACCTGAATACAGCCCACCGCCCCATTGACCACTGGGATGCA
  GTCAACCTGGAATGCTTTGAAGAGGACCCAGGGCGCAAGTGGATGGACAGCTTGCTCAGT
  AACTTGGGGTGGCAGTCTGCCTCTCATGTAGGGCCCTTCATCGATAGCTACCGCTGCTTC
  CAACCAAAGCAGGAGGGGGCCTTCACCTGCTGGTCAGCAGTCACTGGCGCCCGCCATCTC
  ACTATGGCTCCCGGCTTGACTATGTGCTGGGGGGACAGA
  
• Restriction Sites: Please inquire
• ACCN: NM_014481
• ORF Size: 1557 bp
• Insert Size: 1953
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_014481.2, NP_055296.2
• RefSeq Size: 1991
• RefSeq ORF: 1557
• Locus ID: 27301
• Protein Families: Druggable Genome
• Protein Pathways: Base excision repair
• Gene Summary: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).