LIN7 (LIN7B) (NM_022165) Human Untagged Clone

CAT#: SC122930

LIN7B (untagged)-Human lin-7 homolog B (C. elegans) (LIN7B)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LIN7B
• Synonyms: LIN-7B; MALS-2; MALS2; VELI2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_022165 edited
  GGCGGCTGTGGCGCCGACATGGCTGCGCTGGTGGAGCCGCTGGGGCTGGAGCGGGACGTG
  TCCCGGGCGGTTGAGCTCCTCGAGCGGCTCCAGCGCAGCGGGGAGCTGCCGCCGCAGAAG
  CTGCAGGCCCTCCAGCGAGTTCTGCAGAGCCGCTTCTGCTCCGCTATCCGAGAGGTGTAT
  GAGCAGCTTTATGACACGCTGGACATCACCGGCAGCGCCGAGATCCGAGCCCATGCCACA
  GCCAAGGCCACAGTGGCTGCCTTCACAGCCAGCGAGGGCCACGCACATCCCAGGGTAGTG
  GAGCTACCCAAGACGGATGAGGGCCTAGGCTTCAACATCATGGGTGGCAAAGAGCAAAAC
  TCGCCCATCTACATCTCCCGGGTCATCCCAGGGGGTGTGGCTGACCGCCATGGAGGCCTC
  AAGCGTGGGGATCAACTGTTGTCGGTGAACGGTGTGAGCGTTGAGGGTGAGCAGCATGAG
  AAGGCGGTGGAGCTGCTGAAGGCGGCCCAGGGCTCGGTGAAGCTGGTTGTCCGTTACACA
  CCGCGAGTGCTGGAGGAGATGGAGGCCCGGTTCGAGAAGATGCGCTCTGCCCGCCGGCGC
  CAACAGCATCAGAGCTACTCGTCCTTGGAGTCTCGAGGTTGAAACCACAGATCTGGACGT
  TCACGTGCACTCTCTTCCTGTACAGTATTTATTGTTCCTGGCACTTTATTTAAAGATATT
  TGACCCTCAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_022165 unedited
  GCTCANCATTTGTNATACGACTTACTATAGGGCGGCCGCATAACTTCGTATAGCATACAT
  TATACGAAGTTATGGATCAAGCCAAATCGGCCGAGCTCGAATTCGTCGAGAGCGGGGCGG
  CTGTGGCGCCGACATGGCTGCGCTGGTGGAGCCGCTGGGGCTGGAGCGGGACGTGTCCCG
  GGCGGTTGAGCTCCTCGAGCGGCTCCAGCGCAGCGGGGAGCTGCCGCCGCAGAAGCTGCA
  TGCCCTCCAGCGAGTTCTGCAGAGCCGCTTCTGCTCCGCTATCCGAGAGGTGTATGAGCA
  GCTTTATGACACGCTGGACATCACCGGCAGCGCCGAGATCCGAGCCCATGCCACAGCCAA
  GGCCACAGTGGCTGCCTTCACAGCCAGCGAGGGCCACGCACATCCCAGGGTAGTGGAGCT
  ACCCAAGACGGATGAGGGCCTAGGCTTCAACATCATGGGTGGCAAAGAGCAAAACTCGCC
  CATCTACATCTCCCGGGTCATCCCAAGGGGTGTGGCTGACCGCCATGGAGGCCTCAAGCG
  TGGGGATCAACTGTTGTCGGTGAACGGTGTGAGCGTTGAGGGTGAGCAGCATGAGAGGGC
  GGTGGAGCTGCTGAAGGCGGCCCCAAGGCTCGGTGAAACTGTTTGGCCGTTACCCACCCC
  GAGTGCTGGAGGAAAATGAAGCCCAGGTCCGAGAAGATCCCCTCTGCCCCGCCGGGGCCA
  AACGGCTTCAGAACCACTTCGTGCCTTGGAGTCTCGAGGGTGGAAACCCCAAGATCTGGG
  ACGGGCAACGTGCACTCTCCTTCCTGGGAAAGATTTTTATTGGTTCCCGGGCCCCTTTAT
  TATAAGAAATCTGGACCCCAAGAATAAAAAAAAAAACTCTCCAACCCTGGATCCCGCCCT
  AAGGGCCCTTGTCCTTCAGGGGGGGCCCGGGCCCATTTTGAGCTTGGGAACCTTAGAN
  
• Restriction Sites: Please inquire
• ACCN: NM_022165
• ORF Size: 624 bp
• Insert Size: 749
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_022165.2, NP_071448.1
• RefSeq Size: 755
• RefSeq ORF: 624
• Locus ID: 64130
• Protein Families: Druggable Genome
• Gene Summary: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).