DUOXA1 (NM_144565) Human Untagged Clone

CAT#: SC123168

DUOXA1 (untagged)-Human dual oxidase maturation factor 1 (DUOXA1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DUOXA1
• Synonyms: mol; NIP; NUMBIP
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_144565 edited
  CTTCCAGCGGACGGCAGCGCGCGAGACCAGGCCAGGCGTCAAAGCAAGTCACCCATCCGA
  CCTAAACCCCTCTAAGACCCTGGAGTCACGTCTCCCTCCGGGGATCCTCGTGAGGTCTTG
  GGGGTCCCACCGCCCTGCGAGCCGCGCCCGCGCCCCGCCAGACCCGGAACTGCGTCGCTA
  GAACGTCGGGACCTGGTTCCCTCTTTAATCACACCCCCGGGGGCGCTTCGTGTGAGGTTC
  CACGGGGGAAGGCGAGAGGCGCAGGCTGCCACACACGCACTGTTTGGAAGAGGGGAAGGG
  CTGCACTTCCTGCTTTCATCCAGACCAAGTTCGGATCAAGTGGGAGTTCTTCAAAGAGAG
  AGTTTGCATTGCCCCCCCTGCACCACCTCACCAAGATGGCTACTTTGGGACACACATTCC
  CCTTCTATGCTGGCCCCAAGCCAACCTTCCCGATGGACACCACTTTGGCCAGCATCATCA
  TGATCTTTCTGACTGCACTGGCCACGTTCATCGTCATCCTGCCTGGCATTCGGGGAAAGA
  CGAGGCTGTTCTGGCTGCTTCGGGTGGTGACCAGCTTATTCATCGGGGCTGCAATCCTGG
  GGACCCCCGTGCAGCAGCTGAATGAGACCATCAATTACAACGAGGAGTTCACCTGGCGCC
  TGGGTGAGAACTATGCTGAGGAGTATGCAAAGGCTCTGGAGAAGGGGCTGCCAGACCCTG
  TGTTGTACCTAGCTGAGAAGTTCACTCCAAGAAGCCCATGTGGCCTATACCGCCAGTACC
  GCCTGGCGGGACACTACACCTCAGCCATGCTATGGGTGGCATTCCTCTGCTGGCTGCTGG
  CCAATGTGATGCTCTCCATGCCTGTGCTGGTATATGGTGGCTACATGCTATTGGCCACGG
  GCATCTTCCAGCTGTTGGCTCTGCTCTTCTTCTCCATGGCCACATCACTCACCTCACCCT
  GTCCCCTGCACCTGGGCGCTTCTGTGCTGCATACTCACCATGGGCCTGCCTTCTGGATCA
  CATTGACCACAGGACTGCTGTGTGTGCTGCTGGGCCTGGCTATGGCGGTGGCCCACAGGA
  TGCAGCCTCACAGGCTGAAGGCTTTCTTCAACCAGAGTGTGGATGAAGACCCCATGCTGG
  AGTGGAGTCCTGAGGAAGGTGGACTCCTGAGCCCCCGCTACCGGTCCATGGCTGACAGTC
  CCAAGTCCCAGGACATTCCCCTGTCAGAGGCTTCCTCCACCAAGGCATACTGTAAGGAGG
  CACACCCCAAAGATCCTGATTGTGCTTTATAACATTCCTCCCCGTGGAGGCCACCTGGAC
  TTCCAGTCTGGCTCCAAACCTCATTGGCGCCCCATAAAACCAGCAGAACTGCCCTCAGGG
  TGGCTGTTACCAGACACCCAGCACCAATCTACAGACGGAGTAGAAAAAGGAGGCTCTATA
  TACTGATGTTAAAAAACAAAACAAAACAAAAAGCCCTAAGGGACTGAAGAGATGCTGGGC
  CTGTCCATAAAGCCTGTTGCCATGATAAGGCCAAGCAGGGGCTAGCTTATCTGCACAGCA
  ACCCAGCCTTTCCGTGCTGCCTTGCCTCTTCAAGATGCTATTCACTGAAACCTAACTTCA
  CCCCCATAACACCAGCAGGGTGGGGGTTACATATGATTCTCCTATGGTTTCCTCGCAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAA
  
• Restriction Sites: Please inquire
• ACCN: NM_144565
• ORF Size: 1452 bp
• Insert Size: 1706
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_144565.2, NP_653166.2
• RefSeq Size: 1923
• RefSeq ORF: 1452
• Locus ID: 90527
• Protein Families: Transmembrane
• Gene Summary: Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
  Transcript Variant: This variant (1) encodes the longest isoform (1, also known as gamma). Variants 1 and 2 encode the same isoform 1.