IL5RA (NM_175728) Human Untagged Clone

CAT#: SC123343

IL5RA (untagged)-Human interleukin 5 receptor, alpha (IL5RA), transcript variant 6


  "NM_175728" in other vectors (6)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol IL5RA
Synonyms CD125; CDw125; HSIL5R3; IL5R
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_175728 edited
ACGGTTGCTCTGTACAAATCCTCCTCCATATTTGCTTAGAGAAAACGTGTTGCCATCCCA
TCATGAAGGAAGCTGCCTGAGAGTTTTTAACCATTACAGCCGTGATGATGAAAGAGTGAA
GAACCGCCTCTAAGTTAAAAAGTGCACCCAGAGATAAGGTTCGTTCTCAATGCTCTGCCG
CTGCTTCTCATCGCATGGCCACCGCATTTCTCAGGCCAGGCACATTGAGCATTGGTCCTG
TGCCTGACGCTATGCTAGATGCTGGGGTTGCAGCCACGAGCATAGACACGACAGACACGG
TCCTCGCCATCTTCTGTTGAGTACTGGTCGGAACAAGAGGATCGTCTGTAGACAGGATAT
GATCATCGTGGCGCATGTATTACTCATCCTTTTGGGGGCCACTGAGATACTGCAAGCTGA
CTTACTTCCTGATGAAAAGATTTCACTTCTCCCGCCTGTCAATTTCACCATTAAAGTTAC
TGGTTTGGCTCAAGTTCTTTTACAATGGAAACCAAATCCTGATCAAGAGCAAAGGAATGT
TAATCTAGAATATCAAGTGAAAATAAACGCTCCAAAAGAAGATGACTATGAAACCAGAAT
CACTGAAAGCAAATGTGTAACCATCCTCCACAAGGGCTTTTCAGCAAGTGTGCGGACCAT
CCTGCAGAACGACCACTCACTACTGGCCAGCAGCTGGGCTTCTGCTGAACTTCATGCCCC
ACCAGGGTCTCCTGGAACCTCAATTGTGAATTTAACTTGCACCACAAACACTACAGAAGA
CAATTATTCACGTTTAAGGTCATACCAAGTTTCCCTTCACTGCACCTGGCTTGTTGGCAC
AGATGCCCCTGAGGACACGCAGTATTTTCTCTACTATAGGTATGGCTCTTGGACTGAAGA
ATGCCAAGAATACAGCAAAGACACACTGGGGAGAAATATCGCATGCTGGTTTCCCAGGAC
TTTTATCCTCAGCAAAGGGCGTGACTGGCTTGCGGTGCTTGTTGACGGCTCCAGCAAGCA
CTCTGCTATCAGGCCCTTTGATCAGCTGTTTGCCCTTCACGCCATTGATCAAATAAATCC
TCCACTGAATGTCACAGCAGAGATTGAAGGAACTCGTCTCTCTATCCAATGGGAGAAACC
AGTGTCTGCTTTTCCAATCCATTGCTTTGATTATGAAGTAAAAATACACAATACAAGGAA
TGGATATTTGCAGATAGAAAAATTGATGACCAATGCATTCATCTCAATAATTGATGATCT
TTCTAAGTACGATGTTCAAGTGAGAGCAGCAGTGAGCTCCATGTGCAGAGAGGCAGGGCT
CTGGAGTGAGTGGAGCCAACCTATTTATGTGGGGTTCTCAAGATAAAGGAGATAACATCC
AGCTTTCCTGCCCCACACCGTATCTGAAATAAAAACAACAGCAGGAAAAAAAAAAAAAAA
>OriGene 5' read for NM_175728 unedited
CCTGTTAGCATTTGTAAACGACTTATATAGGCGGCCGCATAACTTCGTATAGCATACATT
ATATGAAGTTATGGATCAGGCCAAATCGGCCGAGCTCGAATTCGTCGAGAGCGGACGGTT
GCTCTGTACAAATCCTCCTCCATATTTGCTTAGAGAAAACGTGTTGCCATCCCATCATGA
AGGAAGCTGCCTGAGAGTTTTTAACCATTACAGCCGTGATGATGAAAGAGTGAAGAACCG
CCTCTGAGTTAAAAAGTGCACCCAGAGATAAGGTTCGTTCTCAATGCTCTGCCGCTGCTT
CTCATCGCATGGCCACCGCATTTCTCAGGCCAGGCACATTGAGCATTGGTCCTGTGCCTG
ACGCTATGCTAGATGCTGGGGTTGCAGCCACGAGCATAGACACGACAGACACGGTCCTCG
CCATCTTCTGTTGAGTACTGGTCGGAACAAGAGGATCGTCTGTAGACAGGATATGATCAT
CGTGGCGCATGTATTACTCATCCTTTTGGGGGCCACTGAGATACTGCAAGCTGACTTACT
TCCTGATGAAAAGATTTCACTTCTCCCGCCTGTCAATTTCACCATTAAAGTTACTGGTTT
GGCTCAAGTTCTTTTACAATGGAAACCAAATCCTGATCAAGAGCAAAGGAATGTTAATCT
AGAATATCAAGTGAAAATAAACGCTCCAAAAGAAGATGACTATGANACCAGAATCACTGA
NAGCAAATGTGTAACCATCCTCCACAAGGGCTTTTCAGCAAGTGTGCGGACCATCCTGCA
GAACGACCACTCACTACTGGCCAGCAGCTGGGCTTCTGCTGAACTTCATGCCCCACCAGG
GTCTCCTGGAACCTCATTGTGAATTTAACTGCACCACAACACTACAGAAGACATTATTCC
GTTTAAGTCATACCN
Restriction Sites Please inquire     
ACCN NM_175728
Insert Size 1445 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_175728.1, NP_783855.1
RefSeq Size 1626 bp
RefSeq ORF 1008 bp
Locus ID 3568
Cytogenetics 3p26.2
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway
Gene Summary 'The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]'
Transcript Variant: This variant (6) lacks an internal segment within the 5' UTR, and differs in the 3' end region, when compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1.

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