IL21 Receptor (IL21R) (NM_181078) Human Untagged Clone

CAT#: SC123367

IL21R (untagged)-Human interleukin 21 receptor (IL21R), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IL21R
• Synonyms: CD360; IMD56; NILR
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_181078 edited
  CCCCCAGAAGCCCATCAGACTGCCCCCAGCACACGGAATGGATTTCTGAGAAAGAAGCCG
  AAACAGAAGGCCCGTGGGAGTCAGCATGCCGCGTGGCTGGGCCGCCCCCTTGCTCCTGCT
  GCTGCTCCAGGGAGGCTGGGGCTGCCCCGACCTCGTCTGCTACACCGATTACCTCCAGAC
  GGTCATCTGCATCCTGGAAATGTGGAACCTCCACCCCAGCACGCTCACCCTTACCTGGCA
  AGACCAGTATGAAGAGCTGAAGGACGAGGCCACCTCCTGCAGCCTCCACAGGTCGGCCCA
  CAATGCCACGCATGCCACCTACACCTGCCACATGGATGTATTCCACTTCATGGCCGACGA
  CATTTTCAGTGTCAACATCACAGACCAGTCTGGCAACTACTCCCAGGAGTGTGGCAGCTT
  TCTCCTGGCTGAGAGCATCAAGCCGGCTCCCCCTTTCAACGTGACTGTGACCTTCTCAGG
  ACAGTATAATATCTCCTGGCGCTCAGATTACGAAGACCCTGCCTTCTACATGCTGAAGGG
  CAAGCTTCAGTATGAGCTGCAGTACAGGAACCGGGGAGACCCCTGGGCTGTGAGTCCGAG
  GAGAAAGCTGATCTCAGTGGACTCAAGAAGTGTCTCCCTCCTCCCCCTGGAGTTCCGCAA
  AGACTCGAGCTATGAGCTGCAGGTGCGGGCAGGGCCCATGCCTGGCTCCTCCTACCAGGG
  GACCTGGAGTGAATGGAGTGACCCGGTCATCTTTCAGACCCAGTCAGAGGAGTTAAAGGA
  AGGCTGGAACCCTCACCTGCTGCTTCTCCTCCTGCTTGTCATAGTCTTCATTCCTGCCTT
  CTGGAGCCTGAAGACCCATCCATTGTGGAGGCTATGGAAGAAGATATGGGCCGTCCCCAG
  CCCTGAGCGGTTCTTCATGCCCCTGTACAAGGGCTGCAGCGGAGACTTCAAGAAATGGGT
  GGGTGCACCCTTCACTGGCTCCAGCCTGGAGCTGGGACCCTGGAGCCCAGAGGTGCCCTC
  CACCCTGGAGGTGTACAGCTGCCACCCACCACGGAGCCCGGCCAAGAGGCTGCAGCTCAC
  GGAGCTACAAGAACCAGCAGAGCTGGTGGAGTCTGACGGTGTGCCCAAGCCCAGCTTCTG
  GCCGACAGCCCAGAACTCGGGGGGCTCAGCTTACAGTGAGGAGAGGGATCGGCCATACGG
  CCTGGTGTCCATTGACACAGTGACTGTGCTAGATGCAGAGGGGCCATGCACCTGGCCCTG
  CAGCTGTGAGGATGACGGCTACCCAGCCCTGGACCTGGATGCTGGCCTGGAGCCCAGCCC
  AGGCCTAGAGGACCCACTCTTGGATGCAGGGACCACAGTCCTGTCCTGTGGCTGTGTCTC
  AGCTGGCAGCCCTGGGCTAGGAGGGCCCCTGGGAAGCCTCCTGGACAGACTAAAGCCACC
  CCTTGCAGATGGGGAGGACTGGGCTGGGGGACTGCCCTGGGGTGGCCGGTCACCTGGAGG
  GGTCTCAGAGAGTGAGGCGGGCTCACCCCTGGCCGGCCTGGATATGGACACGTTTGACAG
  TGGCTTTGTGGGCTCTGACTGCAGCAGCCCTGTGGAGTGTGACTTCACCAGCCCCGGGGA
  CGAAGGACCCCCCCGGAGCTACCTCCGCCAGTGGGTGGTCATTCCTCCGCCACTTTCGAG
  CCCTGGACCCCAGGCCAGCTAATGAGGCTGACTGGATGTCCAGAGCTGGCCAGGCCACTG
  GGCCCTGAGCCAGAGACAAGGTCACCTGGGCTGTGATGTGAAGACACCTGCAGCCTTTGG
  TCTCCTGGATGGGCCTTTGAGCCTGATGTTTACAGTGTCTGTGTGTGTGTGTGCATATGT
  GTGTGTGTGCATATGCATGTGTGTGTGTGTGTGTGTCTTAGGTGCGCAGTGGCATGTCCA
  CGTGTGTGTGTGATTGCACGTGCCTGTGGGCCTGGGATAATGCCCATGGTACTCCATGCA
  TTCACCTGCCCTGTGCATGTCTGGACTCACGGAGCTCACCCATGTGCACAAGTGTGCACA
  GTAAACGTGTTTGTGGTCAACAGATGACAACAGCCGTCCTCCCTCCTAGGGTCTTGTGTT
  GCAAGTTGGTCCACAGCATCTCCGGGGCTTTGTGGGATCAGGGCATTGCCTGTGACTGAG
  GCGGAGCCCAGCCCTCCAGCGTCTGCCTCCAGGAGCTGCAAGAAGTCCATATTGTTCCTT
  ATCACCTGCCAACAGGAAGCGAAAGGGGATGGAGTGAGCCCATGGTGACCTCGGGAATGG
  CAATTTTTTGGGCGGCCCCTGGACGAAGGTCTGAATCCCGACTCTGATACCTTCTGGCTG
  TGCTACCTGAGCCAAGTCGCCTCCCCTCTCTGGGCTAGAGTTTCCTTATCCAGACAGTGG
  GGAAGGCATGACACACCTGGGGGAAATTGGCGATGTCACCCGTGTACGGTACGCAGCCCA
  GAGCAGACCCTCAATAAACGTCAGCTTCCTTCCTTCTGCGGCCAGAGCCGAGGCGGGCGG
  GGGTGAGAACATCAATCGTCAGCGACAGCCTGGGCACCCGCGGGGCCGTCCCGCCTGCAG
  AGGGCCACTCGGGGGGGTTTCCAGGCTTAAAATCAGTCCGTTTCGTCTCTTGGAAACAGC
  TCCCCACCAACCAAGATTTCTTTTTCTAACTTCTGCTACTAAGTTTTTAAAAATTCCCTT
  TATGCACCCAAGAGATATTTATTAAACACCAATTACGTAGCAGGCCATGGCTCATGGGAC
  CCACCCCCCGTGGCACTCATGGAGGGGGCTGCAGGTTGGAACTATGCAGTGTGCTCCGGC
  CACACATCCTGCTGGGCCCCCTACCCTGCCCCAATTCAATCCTGCCAATAAATCCTGTCT
  TATTTGTTCATCCTGGAGAATTGAAGGGAGGTCAAGTTGTTTGTCAATGATTTGTCAGAG
  AACCTGTTGAAATGTGAATTAAGAAGCTAAGAAAATAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_181078 unedited
  NGGGAAAGTTCACATTTGTATACGACTCACTATAGGCGGCCGCGNAATTCGCACGAGGCC
  CCCATAAGCCCATCATACTGCCCCCAGCACACGGAATGGATTTCTGAGAAAGAAGCCGAA
  ACAGAAGGCCCGTGGGAGTCAGCATGCCGCGTGGCTGGGCCGCCCCCTTGCTCCTGCTGC
  TGCTCCAGGGAGGCTGGGGCTGCCCCGACCTCGTCTGCTACACCGATTACCTCCAGACGG
  TCATCTGCATCCTGGAAATGTGGAACCTCCACCCCAGCACGCTCACCCTTACCTGGCAAG
  ACCAGTATGAAGAGCTGAAGGACGAGGCCACCTCCTGCAGCCTCCACAGGTCGGCCCACA
  ATGCCACGCATGCCACCTACACCTGCCACATGGATGTATTCCACTTCATGGCCGACGACA
  TTTTCAGTGTCAACATCACAGACCAGTCTGGCAACTACTCCCAGGAGTGTGGCAGCTTTC
  TCCTGGCTGAGAGCATCAAGCCGGCTCCCCCTTTCAACGTGACTGTGACCTTCTCAGGAC
  AGTATAATATCTCCTGGCGCTCAGATTACGAAGACCCTGCCTTCTACATGCTGAAGGGCA
  AGCTTCAGTATGAGCTGCAGTACAGGAACCGGGGAGACCCCTGGGCTGTGAGTCCGAGGA
  GAAAGCTGATCTCAGTGGACTCAAGAAGTGTCTCCCTCCTCCCCCTGGAGTTCCGCANAG
  ACTCGAGCTATGAGCTGCAGGTGCGGGCAGGGCCCATGCCTGGCTCCTCCTACCAGGGAC
  CTGGAGTGAATGGAGTGACCCGGTCATCTTTCAGACCAGTCAGAGGAGTAAGGAAGGCTG
  NACCCTCACTGCTGCTTCTCT
  
• Restriction Sites: Please inquire
• ACCN: NM_181078
• ORF Size: 1617 bp
• Insert Size: 3014
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_181078.1, NP_851564.1
• RefSeq Size: 3361
• RefSeq ORF: 1617
• Locus ID: 50615
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
• Gene Summary: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
  Transcript Variant: This variant (2) encodes the dominant isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.