Hyaluronan synthase 1 (HAS1) (BC035837) Human Untagged Clone

CAT#: SC123464

HAS1 (untagged)-Human hyaluronan synthase 1 (cDNA clone MGC:46218 IMAGE:5589083), complete cds


Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol HAS1
Synonyms HAS; hyaluronan synthase 1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for BC035837 edited
GCAAGCCGGAGAGAAGAGAGAGCCCGGCCAGACCCACTGCGATGAGACAGGACGCGCCCA
AGCCCACTCCTGCAGCCCGCCGCTGCTCCGGCCTGGCCCGGAGGGTGCTGACCATCGCCT
TCGCCCTGCTCATCCTGGGCCTCATGACCTGGGCCTACGCCGCCGGGGTGCCGCTGGCCT
CCGATCGCTACGGCCTCCTGGCCTTCGGCCTCTACGGGGCCTTCCTTTCAGCGCACCTGG
TGGCGCAGAGCCTCTTCGCGTACCTGGAGCACCGGCGGGTGGCGGCGGCGGCGCGGGGGC
CGCTGGATGCAGCCACCGCGCGCAGTGTGGCGCTGACCATCTCCGCCTACCAGGAGGACC
CCGCGTACCTGCGCCAGTGCCTGGCGTCCGCCCGCGCCCTGCTGTACCCGCGCGCGCGGC
TGCGCGTCCTCATGGTGGTGGATGGCAACCGCGCCGAGGACCTCTACATGGTCGACATGT
TCCGCGAGGTCTTCGCTGACGAGGACCCCGCCACGTACGTGTGGGACGGCAACTACCACC
AGCCCTGGGAACCCGCGGCGGCGGGCGCGGTGGGCGCCGGAGCCTATCGGGAGGTGGAGG
CGGAGGATCCTGGGCGGCTGGCAGTGGAGGCGCTGGTGAGGACTCGTAGGTGCGTGTGCG
TGGCGCAGCGCTGGGGCGGCAAGCGCGAGGTCATGTACACAGCCTTCAAGGCGCTCGGAG
ATTCGATGGACTACGTGCAGGTCTGTGACTCGGACACAAGGTTGGACCCCATGGCACTGC
TGGAGCTCGTGCGGGTACTGGACGAGGACCCCCGGGTAGGGGCTGTTGGTGGGGACGTGC
GGATCCTTAACCCTCTGGACTCCTGGGTCAGCTTCCTAAGCAGCCTGCGATACTGGGTAG
CCTTCAATGTGGAGCGGGCTTGTCAGAGCTACTTCCACTGTGTATCCTGCATCAGCGGTC
CTCTAGGCCTATATAGGAATAACCTCTTGCAGCAGTTTCTTGAGGCCTGGTACAACCAGA
AGTTCCTGGGTACCCACTGTACTTTTGGGGATGACCGGCACCTCACCAACCGCATGCTCA
GCATGGGTTATGCTACCAAGTACACCTCCAGGTCCCGCTGCTACTCAGAGACGCCCTCGT
CCTTCCTGCGGTGGCTGAGCCAGCAGACACGCTGGTCCAAGTCGTACTTCCGTGAGTGGC
TGTACAACGCGCTCTGGTGGCACCGGCACCATGCGTGGATGACCTACGAGGCGGTGGTCT
CCGGCCTGTTCCCCTTCTTCGTGGCGGCCACTGTGCTGCGTCTGTTCTACGCGGGCCGCC
CTTGGGCGCTGCTGTGGGTGCTGCTGTGCGTGCAGGGCGTGGCACTGGCCAAGGCGGCCT
TCGCGGCCTGGCTGCGGGGCTGCCTGCGCATGGTGCTTCTGTCGCTCTACGCGCCCCTCT
ACATGTGTGGCCTCCTGCCTGCCAAGTTCCTGGCGCTAGTCACCATGAACCAGAGTGGCT
GGGGCACCTCGGGCCGGCGGAAGCTGGCCGCTAACTACGTCCCTCTGCTGCCCCTGGCGC
TCTGGGCGCTGCTGCTGCTTGGGGGCCTGGTCCGCAGCGTAGCACACGAGGCCAGGGCCG
ACTGGAGCGGCCCTTCCCGCGCAGCCGAGGCCTACCACTTGGCCGCGGGGGCCGGCGCCT
ACGTGGGCTACTGGGTGGCCATGTTGACGCTGTACTGGGTGGGCGTGCGGAGGCTTTGCC
GGCGGCGGACCGGGGGCTACCGCGTCCAGGTGTGAGTCCAGCCACGCGGATGCCGCCTCA
AGGGTCTTCAGGGGAGGCCAGAGGAGAGCTGCTGGGCCCCGAGCCACGAACTTGCTGGGT
GGTTCTCTGGGCCTCAGTTTCCCTCCTCTGCAAAACGAGGGGGTCAGCCCAAGATTCTTC
AGTCTGGACTATATTGGGACTGGGACTTCTGGGTCTCCAGGGAGGGTATTTATTGGTCAG
GGTGTGGGATCTGAGGAGTGGAGGGAAAGGGTCCTGCTTTCTCCTCGTTCTTATTTAATC
TCCATTTCTACTGTGTGATCAGGATGTAATAAAGAATTTTATTTATTTTCAAAAAAAAAA
AAAAAAAAAAAAAAAAAAA
>OriGene 5' read for BC035837 unedited
GGGGTTCGCATTTGTATACGACTCATATAGGCGGCCGCGNATTCCCGGGATAGCAAGCCG
GAGAGAAGAGAGAGCCCGGCCAGACCCACTGCGATGAGACAGGACGCGCCCAAGCCCACT
CCTGCAGCCCGCCGCTGCTCCGGCCTGGCCCGGAGGGTGCTGACCATCGCCTTCGCCCTG
CTCATCCTGGGCCTCATGACCTGGGCCTACGCCGCCGGGGTGCCGCTGGCCTCCGATCGC
TACGGCCTCCTGGCCTTCGGCCTCTACGGGGCCTTCCTTTCAGCGCACCTGGTGGCGCAG
AGCCTCTTCGCGTACCTGGAGCACCGGCGGGTGGCGGCGGCGGCGCGGGGGCCGCTGGAT
GCAGCCACCGCGCGCAGTGTGGCGCTGACCATCTCCGCCTACCAGGAGGACCCCGCGTAC
CTGCGCCAGTGCCTGGCGTCCGCCCGCGCCCTGCTGTACCCGCGCGCGCGGCTGCGCGTC
CTCATGGTGGTGGATGGCAACCGCGCCGAGGACCTCTACATGGTCGACATGTTCCGCGAG
GTCTTCGCTGACGAGGACCCCGCCACGTACGTGTGGGACGGCAACTACCACCAGCCCTGG
GAACCCGCGGCGGCGGGCGCGGTGGGCGCCGGAGCCTATCGGGAGGTGGAGGCGGAGGAT
CCTGGGCGGCTGGCAGTGGAGGCGCTGGTGAGGACTCGTANGTGCGTGTGCGTGGCGCAC
CGCTGGGGCGGCAAGCGCGAGGTCATGTACACAGCCTTCAAGGCGCTCGNAGATTCGATG
GACTACGTGCAGGTCTGTGACTCGGACACCAGGTTGGGACCCCATGCACTGCTGGAGCTC
GTGCGGGTACTGGACGAANACCCCCGGGTAGGGGCTGTTGGTGGGGACGTGCGGATCCTT
AAACCTCTGGACTCN
Restriction Sites Please inquire     
ACCN BC035837
Insert Size 2119 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq BC035837.1, AAH35837.1
RefSeq Size 2119 bp
RefSeq ORF 1731 bp
Locus ID 3036
Cytogenetics 19q13.41
Protein Families Druggable Genome, Transmembrane
Gene Summary 'Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]'

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