DNMT3L (BC002560) Human Untagged Clone

CAT#: SC123782

DNMT3L (untagged)-Human DNA (cytosine-5-)-methyltransferase 3-like, transcript variant 2 (cDNA clone MGC:1090 IMAGE:3138514), complete cds

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DNMT3L
• Synonyms: cytosine-5-methyltransferase 3-like protein; DNA (cytosine-5-)-methyltransferase 3-like; human cytosine-5-methyltransferase 3-like protein; MGC1090
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for BC002560 edited
  GTGGGCCTGGATCCTTCCAGCTCATTCTTTGCCTGCGCCGTCCCTCGTTCCATGGCCCAG
  TCCTCCCCGGGGACCCTGAGCCTGGAAGCCCCGGACCACTGGAACCTTGAACCCACCAGC
  TGGCTGTACCCGGAGCCGTGGCAGCAGCCCTCATCCCCATGGCGGCCATCCCAGCCCTGG
  ACCCAGAGGCCGAGCCCAGCATGGACGTGATTTTGGTGGGATCCAGTGAGCTCTCAAGCT
  CCGTTTCACCCGGGACAGGCAGAGATCTTATTGCATATGAAGTCAAGGCTAACCAGCGAA
  ATATAGAAGACATCTGCATCTGCTGCGGAAGTCTCCAGGTTCACACACAGCACCCTCTGT
  TTGAGGGAGGGATCTGCGCCCCATGTAAGGACAAGTTCCTGGATGCCCTCTTCCTGTACG
  ACGATGACGGGTACCAATCCTACTGCTCCATCTGCTGCTCCGGAGAGACGCTGCTCATCT
  GCGGAAACCCTGATTGCACCCGATGCTACTGCTTCGAGTGTGTGGATAGCCTGGTCGGCC
  CCGGGACCTCGGGGAAGGTGCACGCCATGAGCAACTGGGTGTGCTACCTGTGCCTGCCGT
  CCTCCCGAAGCGGGCTGCTGCAGCGTCGGAGGAAGTGGCGCAGCCAGCTCAAGGCCTTCT
  ACGACCGAGAGTCGGAGAATCCCCTTGAGATGTTCGAAACCGTGCCTGTGTGGAGGAGAC
  AGCCAGTCCGGGTGCTGTCCCTTTTTGAAGACATCAAGAAAGAGCTGACGAGTTTGGGCT
  TTTTGGAAAGTGGTTCTGACCCGGGACAACTGAAGCATGTGGTTGATGTCACAGACACAG
  TGAGGAAGGATGTGGAGGAGTGGGGACCCTTCGATCTTGTGTACGGCGCCACACCTCCCC
  TGGGCCACACCTGTGACCGTCCTCCCAGCTGGTACCTGTTCCAGTTCCACCGGCTCCTGC
  AGTACGCACGGCCCAAGCCAGGCAGCCCCGGGCCCTTCTTCTGGATGTTCGTGGACAATC
  TGGTGCTGAACAAGGAAGACCTGGACGTCGCATCTCGCTTCCTGGAGATGGAGCCAGTCA
  CCATCCCAGATGTCCACGGCGGATCCTTGCAGAATGCTGTCCGCGTGTGGAGCAACATCC
  CAGCCATAAGGAGCAGGCACTGGGCTCTGGTTTCGGAAGAAGAATTGTCCCTGCTGGCCC
  AGAACAAGCAGAGCTCGAAGCTCGCGGCCAAGTGGCCCACCAAGCTGGTGAAGAACTGCT
  TTCTCCCCCTAAGAGAATATTTCAAGTATTTTTCAACAGAACTCACTTCCTCTTTATAAA
  TGAGTCACTATACTGTGAAGAAAAAGACTTTTCCTAGAACAAAGAAAAAAAAAAAAAAAA
  AAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for BC002560 unedited
  NGGTAAAGTCATACTTTGTAATAGAATCCTATAGGCGGCCCGCGAATTCGCACGAGGTGG
  GCCTGGCTCCTTCCAGCTCATTCTTTGCCTGCGCCGTCCCTCGTTCCATGGCCCAGTCCT
  CCCCGGGGACCCTGAGCCTGGAAGCCCCGGACCACTGGAACCTTGAACCCACCAGCTGGC
  TGTACCCGGAGCCGTGGCAGCAGCCCTCATCCCCATGGCGGCCATCCCAGCCCTGGACCC
  AGAGGCCGAGCCCAGCATGGACGTGATTTTGGTGGGATCCAGTGAGCTCTCAAGCTCCGT
  TTCACCCGGGACAGGCAGAGATCTTATTGCATATGAAGTCAAGGCTAACCAGCGAAATAT
  AGAAGACATCTGCATCTGCTGCGGAAGTCTCCAGGTTCACACACAGCACCCTCTGTTTGA
  GGGAGGGATCTGCGCCCCATGTAAGGACAAGTTCCTGGATGCCCTCTTCCTGTACGACGA
  TGACGGGTACCAATCCTACTGCTCCATCTGCTGCTCCGGAGAGACGCTGCTCATCTGCGG
  AAACCCTGATTGCACCCGATGCTACTGCTTCGAGTGTGTGGATAGCCTGGTCGGCCCCGG
  GACCTCGGGGAAGGTGCACGCCATGAGCAACTGGGTGTGCTACCTGTGCCTGCCGTCCTC
  CCGAAGCGGGCTGCTGCAGCGTCNGAAGAAGTGGCGCAGCCAGCTCAAGGCCTTCTACGA
  CCGAGAGTCGGAGAATCCCCTTGAGATGTTCGAAACCGTGCCTGTGTGGAGGAGACAGCC
  AGTCCGGGTGCTGTCCCTTTTTGAAAGACTCAAAAAGAGCTGACGAGTTTGGGCTTTTTG
  NAAAGTGGTTCTGACCCGGGACAACTGAAGCATGTGGGTGATGTCACAGACACATGAGGA
  AAGAGTA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for BC002560 unedited
  NGACCATTTGGNTGATGGCAACTTCCCAGGTCCAGGNANAGCACTGGGGNAGGGTCACAG
  GGCTGCCACCCGGGTATCTGTTCAGGAAAACAGCTATGACCGCGGCCGCAATCTAGAGTC
  GAGTTTTTTTTTTTTTTTTTTTTTTTTCTTTGTTCTAGGAAAAGTCTTTTTCTTCACAGT
  ATAGTGACTCATTTATAAAGAGGAAGTGAGTTCTGTTGAAAAATACTTGAAATATTCTCT
  TAGGGGGAGAAAGCAGTTCTTCACCAGCTTGGTGGGCCACTTGGCCGCGAGCTTCGAGCT
  CTGCTTGTTCTGGGCCAGCAGGGACAATTCTTCTTCCGAAACCAGAGCCCAGTGCCTGCT
  CCTTATGGCTGGGATGTTGCTCCACACGCGGACAGCATTCTGCAAGGATCCGCCGTGGAC
  ATCTGGGATGGTGACTGGCTCCATCTCCAGGAAGCGAGATGCGACGTCCAGGTCTTCCTT
  GTTCAGCACCAGATTGTCCACGAACATCCAAAAAAAGGGCCCGGGGCTGCCTGGCTTGGG
  CCGTGCGTACTGCAGGAGCCGGTGGAACTGGAACAGGTACCAGCTGGGAGGACGGTCACA
  GGTGTGGCCCAGGGGAGGTGTGGCGCCGTACACAAGATCGAAGGGTCCCCACTCCTCCAC
  ATCCTTCCTCACTGTGTCTGTGACATCAACCACATGCTTCAGTTGTCCCGGGTCAGAACC
  ACTTTTCAAAAAGCCCAAACTCGTCAGCTCTTTCTTGATGTCTTCAAAAAGGGACAGCAC
  CCGGACTGGCTGTCTCCTCCCACAGGCACGGGTTTCGAACATCTCAAGGGGATTCTCCCA
  CTCTCGGTCGTAAAAGGCCTTGAGCTGGCTGCNGCATTTCTTCCGAGCTGCACANCCCGC
  TTCGGGAGGACGGCGGCACAGGTACC
  
• Restriction Sites: Please inquire
• ACCN: BC002560
• Insert Size: 1397
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: BC002560.2, AAH02560.1
• RefSeq Size: 1388
• Locus ID: 29947
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Cysteine and methionine metabolism, Metabolic pathways
• Gene Summary: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]