HLA (BC001023) Human Untagged Clone

CAT#: SC123794

HLA (untagged)-Human cDNA clone MGC:2284 IMAGE:3345335, complete cds


Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

Product Images

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol HLA
Synonyms DRB1|DRw10|HLA-DR1B|HLA-DR3B|HLA-DRB|SS1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for BC001023 edited
GTTCTCCCTGAGTGAGACTCACCTGCTCCTCTGGCCCCTGGTCCTGTCCTGTTCTCCAGC
ATGGTGTGTCTGAAGCTCCCTGGAGGCTCCTGCATGGCAGCTCTGACAGTGACACTGATG
GTGCTGAGCTCCCCACTGGCTTTGGCTGGGGACACCCAACCACGTTTCCTGTGGCAGGGT
AAGTATAAGTGTCATTTCTTCAACGGGACGGAGCGGGTGCAGTTCCTGGAAAGACTCTTC
TATAACCAGGAGGAGTTCGTGCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTGACG
GAGCTAGGGCGGCCTGTCGCCGAGTCCTGGAACAGCCAGAAGGACATCCTGGAGGACAGG
CGGGGCCAGGTGGACACCGTGTGCAGACACAACTACGGGGTTGGTGAGAGCTTCACAGTG
CAGCGGCGAGTCCATCCTGAGGTGACTGTGTATCCTGCCAAGACTCAGCCCCTGCAGCAC
CACAACCTCCTGGTCTGCTCTGTGAGTGGTTTCTATCCAGGCAGCATTGAAGTCAGGTGG
TTCCGGAACGGCCAGGAAGAGAAGGCTGGGGTGGTGTCCACAGGCCTGATCCAGAATGGA
GACTGGACCTTCCAGACCCTGGTGATGCTGGAAACAGTTCCTCGGAGTGGAGAAGTTTAC
ACCTGCCAAGTGGAGCACCCAAGTGTGATGAGCCCTCTCACAGTGGAATGGAGAGCACGG
TCTGAATCTGCACAGAGCAAGATGCTGAGTGGAGTCGGGGGCTTTGTGCTGGGCCTGCTC
TTCCTTGGGGCCGGGTTGTTCATCTACTTCAGGAATCAGAAAGGACACTCTGGACTTCAG
CCAACAGGATTCCTGAGCTGAAGTGAAGATGACCACATTCAAGGAAAAACCTTCTGCCCC
AGCTTTGCAGGATGAAACACTTCCCCGCTTGGCTCTCATTCTTCCACAAGAGAGACCTTT
CTCCGGACCTGGTTGCTACTGGTTCAGCAACTCTGCAGAAAATGTCCTCCCCTGTGGCTG
CCTCAGCTCATGCCTTTGGCCTGAAGTCCCAGCATTGATGGCAGCCCCTCATCTTCCAAG
TTTTGTGCTCCCCTTTACCTAACGCTTCCTGCCTCCCATGCATCTGTACTCCTCCTGTGC
CACAAACACATTACATTATTAAATGTTTCTCAAACATGGAAAAAAAAAAAAAAAAAAAAA
AAA
>OriGene 5' read for BC001023 unedited
NNNAAGGTCAAAATTTGTAAACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGTTCT
CCCTGAGTGAGACTCACCTGCTCCTCTGGCCCCTGGTCCTGTCCTGTTCTCCAGCATGGT
GTGTCTGAAGCTCCCTGGAGGCTCCTGCATGGCAGCTCTGACAGTGACACTGATGGTGCT
GAGCTCCCCACTGGCTTTGGCTGGGGACACCCAACCACGTTTCCTGTGGCAGGGTAAGTA
TAAGTGTCATTTCTTCAACGGGACGGAGCGGGTGCAGTTCCTGGAAAGACTCTTCTATAA
CCAGGAGGAGTTCGTGCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTGACGGAGCT
AGGGCGGCCTGTCGCCGAGTCCTGGAACAGCCAGAAGGACATCCTGGAGGACAGGCGGGG
CCAGGTGGACACCGTGTGCAGACACAACTACGGGGTTGGTGAGAGCTTCACAGTGCAGCG
GCGAGTCCATCCTGAGGTGACTGTGTATCCTGCCAAGACTCAGCCCCTGCAGCACCACAA
CCTCCTGGTCTGCTCTGTGAGTGGTTTCTATCCAGGCAGCATTGAAGTCAGGTGGTTCCG
GAACGGCCAGGAAGAGAAGGCTGGGGTGGTGTCCACAGGCCTGATCCAGAATGGAGACTG
GACCTTCCAGACCCTGGTGATGCTGGAAACAGTTCCTCGGAGTGGAGAAGTTTACACCTG
CCAAGTGGAGCACCCAAGTGTGATGAGCCCTCTCACAGTGGAATGGAGAGCACGGTCTGA
ATCTGCACAGAGCAAGATGCTGAGTGGAGTCGGGGGCTTTGTGCTGGGCCTGCTCTTCCT
GGGGCCGGGTTGGTCATCTACTTCAGGAATCAGAAAGACACTCTGGACTTCACCAACAGG
ATCCTGAGCTG
Restriction Sites Please inquire     
ACCN BC001023
Insert Size 1212 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq BC001023.2, AAH01023.1
RefSeq Size 1203 bp
RefSeq ORF 798 bp
Locus ID 3125
Cytogenetics 6p21.3
Protein Families Transmembrane
Protein Pathways Allograft rejection, Antigen processing and presentation, Asthma, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Hematopoietic cell lineage, Systemic lupus erythematosus, Type I diabetes mellitus, Viral myocarditis
Gene Summary 'HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]'

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