PPAR alpha (PPARA) (NM_032644) Human Untagged Clone

CAT#: SC123806

PPARA (untagged)-Human peroxisome proliferative activated receptor, alpha (PPARA), transcript variant 7


Reconstitution Protocol

USD 660.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PPARA
Synonyms PPAR, NR1C1, hPPAR, MGC2237, MGC2452
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_032644 edited
GAAGTTCAAGATCAAAGTGCCAGCAGATTCAGTGTCATGTGAGGACGTGCTTCCTGCTTC
ATAGATAAGAGTGCCACACCCCCCTGTCCCAGTGCACTGGGGCTGTGGATCCCTTCAAAG
CTGAGATTGCCTGTCTGTGGTCTCCAGCGTTAAGCACAGTCATTAGCTCAGCTTGGAGCT
CGGCGGCACAACCAGCACCATCTGGTCGCGATGGTGGACACGGAAAGCCCACTCTGCCCC
CTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA
ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGC
TTTACGGAATACCAGTATTTAGGAAGCTGTCCTGGCTCAGATGGCTCGGTCATCACGGAC
ACGCTTTCACCAGCTTCGAGCCCCTCCTCGGTGACTTATCCTGTGGTCCCCGGCAGCGTG
GACGAGTCTCCCAGTGGAGCATTGAACATCGAATGTAGAATCTGCGGGGACAAGGCCTCA
GGCTATCATTACGGAGTCCACGCGTGTGAAGGCTGCAAGGGCTTCTTTCGGCGAACGATT
CGACTCAAGCTGGTGTATGACAAGTGCGACCGCAGCTGCAAGATCCAGAAAAAGAACAGA
AACAAATGCCAGTATTGTCGATTTCACAAGTGCCTTTCTGTCGGGATGTCACACAACGCG
ATTCGTTTTGGACGAATGCCAAGATCTGAGAAAGCAAAACTGAAAGCAGAAATTCTTACC
TGTGAACATGACATAGAAGATTCTGAAACTGCAGATCTCAAATCTCTGGCCAAGAGAATC
TACGAGGCCTACTTGAAGAACTTCAACATGAACAAGGTCAAAGCCCGGGTCATCCTCTCA
GGAAAGGCCAGTAACAATCCAGTAGGTGTTTGCGGCTGTTCTGGGTTCTCTTGGCAACAT
GGAACCAGTGTCGTAGAGGACGATTAAGGACACATGTGTTGAATGTTGAGAAAATTATAT
TTATCCCACAGTTAAGCAAAGGACAGCGAAGATGGAAACAGTTCATTCTGAGACTCTGAG
CTGTAGCTTAACAACAACTCCTTTCTTCTTGCTTGGAGCCACCTCAAAGCTCTTAGCAAC
TAAGTTATTATACTGGCTATGTAATTAATACACTTAAAAAAAACCTTAATAGCTTACCAA
GTACTAAGATGATTTCTTAGGAGCATTTTTTCTTAAATAGAGATAGGTTCTTGCTCTGTT
GCCCAGGCTGGAATGCAGTGGTGCAATCATAGTTCACTGCAGCCTTGAACTCCTGGGCTC
AAGCAATCCTCCTGCCTCAGCCTCCCAAGGAGCTGGGACTACAGGTGTGCACCACCACAC
CTGGCTATGTTTGATGTTGTTGTTGTTTTGTTTTGTTTTTGTTTTTTGGTAGAGATGAGA
TGTTTCCCAGGCTGGTCTCAAACTCCTGGCCTCAAGTGATCTTCCCACCTCGGCCTCCCA
AAGCACTGGCATTACAGGTGTGAGTCATGGCACCCAGCATTAACTGGATTTAAAAAAAAA
AAAAAAAAAAA
>OriGene 5' read for NM_032644 unedited
NAAAGTACAGCATTTGTNATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGGNAA
GTTCAATATCAAAGTGCCAGCAGATTCAGTGTCATGTGAGGACGTGCTTCCTGCTTCATA
GATAAGAGTGCCACACCCCCCTGTCCCAGTGCACTGGGGCTGTGGATCCCTTCAAAGCTG
AGATTGCCTGTCTGTGGTCTCCAGCGTTAAGCACAGTCATTAGCTCAGCTTGGAGCTCGG
CGGCACAACCAGCACCATCTGGTCGCGATGGTGGACACGGAAAGCCCACTCTGCCCCCTC
TCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAAATG
GGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTT
ACGGAATACCAGTATTTAGGAAGCTGTCCTGGCTCAGATGGCTCGGTCATCACGGACACG
CTTTCACCAGCTTCGAGCCCCTCCTCGGTGACTTATCCTGTGGTCCCCGGCAGCGTGGAC
GAGTCTCCCAGTGGAGCATTGAACATCGAATGTAGAATCTGCGGGGACAAGGCCTCAGGC
TATCATTACGGAGTCCACGCGTGTGAAGGCTGCAAGGGCTTCTTTCGGCGAACGATTCGA
CTCAAGCTGGTGTATGACAAGTGCGACCGCAGCTGCNAGATCCANGAAAAGAACAGAAAC
AAATGCCAGTATTGTCGATTTCACAAGTGCCTTTCTGTCGGGATGTCACACAACGCGATT
CGTTTTGGACGAATGCCAAGATCTGAGAAAGCANAACTGAAAGCAGAAATTCTTACCTGT
GAACATGACATAGNAAGATTCTGAAACTGCAGATCTCAAATCTCTGGCCAAGAAATCT
>OriGene 3' read for NM_032644 unedited
CCATGGGGCCATTGGGNGATGTGCAACTTCCCAGGNCCAGNANAGCACTGGGGNAGGGTC
ACAGGGCATGCCACCCGGGTATCTGTTCAGGAAAACAGCTATGACCGCGGCCGCAATCTA
GAGTCGAGTTTTTTTTTTTTTTTTTTTTAAATCCAGTTAATGCTGGGTGCCATGACTCAC
ACCTGTAATGCCAGTGCTTTGGGAGGCCGAGGTGGGAAGATCACTTGAGGCCAGGAGTTT
GAGACCAGCCTGGGAAACATCTTATCTCTACCAAAAAACAAAAACAAAACAAAACAACCA
CAACATCAAACATAGCCAGGTGTGGTGGTGCACACCTGTAGTCCCAGCTCCTTGGGAGGC
TGAGGCAGGAGGATTGCTTGAGCCCAGGAGTTCAAGGCTGCAGTGAACTATGATTGCACC
ACTGCATTCCAGCCTGGGCAACAGAGCAAGAACCTATCTCTATTTAAGAAAAAATGCTCC
TAAGAAATCATCTTAGTACTTGGTAAGCTATTAAGGTTTTTTTTAAGTGTATTAATTACA
TAGCCAGTATAATAACTTAGTTGCTAAGAGCTTTGAGGTGGCTCCAAGCAAGAAGAAAGG
AGTTGTTGTTAAGCTACAGCTCAGAGTCTCAGAATGAACTGTTTCCATCTTCGCTGTCCT
TTGCTTAACTGTGGGATAAATATAATTTTCTCAACATTCAACACATGTGTCCTTAATCGT
CCTCTACGACACTGGTTCCATGTTGCCAAGAGAACCCAGNAAAGCCGCAAACACCTACTG
GATTGNTACTGGCCTTTCCTGAGAGGATGACCCGGGCTTTGACCTTGTTCATGTTGGAAT
TCTTCAAGTAGGCCTCGTAGATTTCTTTGGCCAGAGATTTGAGATCTGCAGTTTAGAATT
TTCTATG
Restriction Sites Please inquire     
ACCN NM_032644
Insert Size 1580 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_032644.3, NP_116033.2
RefSeq Size 3370 bp
RefSeq ORF 777 bp
Locus ID 5465
Cytogenetics 22q13.31
Protein Families Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
Protein Pathways Adipocytokine signaling pathway, PPAR signaling pathway
Gene Summary 'Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (7) differs in the 5' UTR and continues past a splice site in the 3' coding region which results in an early stop codon, compared to variant 6. The resulting isoform (2) has a distinct and shorter C-terminus when compared to isoform 1.

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