USH1C (NM_005709) Human Untagged Clone

CAT#: SC123829

USH1C (untagged)-Human Usher syndrome 1C (autosomal recessive, severe) (USH1C), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: USH1C
• Synonyms: AIE-75; DFNB18; DFNB18A; NY-CO-37; NY-CO-38; PDZ-45; PDZ-73; PDZ-73/NY-CO-38; PDZ73; PDZD7C; ush1cpst
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_005709 edited
  GGCCCGGTCGCGGTCGCGGCTCTTTCCAGCTCCTGGCAGCCGGGCACCCGAAGGAACGGG
  TCGTGCAACGACGCAGCTGGACCTGGCCCAGCCATGGACCGAAAAGTGGCCCGAGAATTC
  CGGCATAAGGTGGATTTTCTGATTGAAAATGATGCAGAGAAGGACTATCTCTATGATGTG
  CTGCGAATGTACCACCAGACCATGGACGTGGCCGTGCTCGTGGGAGACCTGAAGCTGGTC
  ATCAATGAACCCAGCCGTCTGCCTCTGTTTGATGCCATTCGGCCGCTGATCCCACTGAAG
  CACCAGGTGGAATATGATCAGCTGACCCCCCGGCGCTCCAGGAAGCTGAAGGAGGTGCGT
  CTGGACCGTCTGCACCCCGAAGGCCTCGGCCTGAGTGTGCGTGGTGGCCTGGAGTTTGGC
  TGTGGGCTCTTCATCTCCCACCTCATCAAAGGCGGTCAGGCAGACAGCGTCGGGCTCCAG
  GTAGGGGACGAGATCGTCCGGATCAATGGATATTCCATCTCCTCCTGTACCCATGAGGAG
  GTCATCAACCTCATTCGAACCAAGAAAACTGTGTCCATCAAAGTGAGACACATCGGCCTG
  ATCCCCGTGAAAAGCTCTCCTGATGAGCCCCTCACTTGGCAGTATGTGGATCAGTTTGTG
  TCGGAATCTGGGGGCGTGCGAGGCAGCCTGGGCTCCCCTGGAAATCGGGAAAACAAGGAG
  AAGAAGGTCTTCATCAGCCTGGTAGGCTCCCGAGGCCTTGGCTGCAGCATTTCCAGCGGC
  CCCATCCAGAAGCCTGGCATCTTTATCAGCCATGTGAAACCTGGCTCCCTGTCTGCTGAG
  GTGGGATTGGAGATAGGGGACCAGATTGTCGAAGTCAATGGCGTCGACTTCTCTAACCTG
  GATCACAAGGAGGGCCGGGAGCTGTTCATGACAGACCGGGAGCGGCTGGCAGAGGCGCGG
  CAGCGTGAGCTGCAGCGGCAGGAGCTTCTCATGCAGAAGCGGCTGGCGATGGAGTCCAAC
  AAGATCCTCCAGGAGCAGCAGGAGATGGAGCGGCAAAGGAGAAAAGAAATTGCCCAGAAG
  GCAGCAGAGGAAAATGAGAGATACCGGAAGGAGATGGAACAGATTGTAGAGGAGGAAGAG
  AAGTTTAAGAAGCAATGGGAAGAAGACTGGGGCTCAAAGGAACAGCTACTCTTGCCTAAA
  ACCATCACTGCTGAGGTACACCCGGTACCCCTTCGCAAGCCAAAGTATGATCAGGGAGTG
  GAACCTGAGCTCGAGCCCGCAGATGACCTGGATGGAGGCACGGAGGAGCAGGGAGAGCAG
  GATTTCCGGAAATATGAGGAAGGCTTTGACCCCTACTCTATGTTCACCCCAGAGCAGATC
  ATGGGGAAGGATGTCCGGCTCCTACGCATCAAGAAGGAGGGATCCTTAGACCTGGCCCTG
  GAAGGCGGTGTGGACTCCCCCATTGGGAAGGTGGTTGTTTCTGCTGTGTATGAGCGGGGA
  GCTGCTGAGCGGCATGGTGGCATTGTGAAAGGGGACGAGATCATGGCAATCAACGGCAAG
  ATTGTGACAGACTACACCCTGGCTGAGGCTGACGCTGCCCTGCAGAAGGCCTGGAATCAG
  GGCGGGGACTGGATCGACCTTGTGGTTGCCGTCTGCCCCCCAAAGGAGTATGACGATGAG
  CTGACCTTCTTCTGAAGTCCAAAAGGGGAAACCAAATTCACCGTTAGGAAACAGTGAGCT
  CCGGCCCCACCTCGTGAACACAAAGCCTCGGATCAGCCTTGAGAGAGGCCACACTACACA
  CACCAGATGGCATCCTTGGGACCTGAATCTATCACCCAGGAATCTCAAACTCCCTTTGGC
  CCTGAACCAGGGCCAGATAAGGAACAGCTCGGGCCACTCTTCTGAAGGCCAACGTGGAGG
  AAAGGGAGCAGCCAGCCATTTGGGAGAAGATCTCAAGGATCCAGACTCTCATTCCTTTCC
  TCTGGCCCAGTGAATTTGGTCTCTCCCAGCTCTGGGGGACTCCTTCCTTGAACCCTAATA
  AGACCCCACTGGAGTCTCTCTCTCTCCATCCCTCTCCTCTGCCCTCTGCTCTAATTGCTG
  CCAGGATTGTCACTCCAAACCTTACTCTGAGCTCATTAATAAAATAAACAGATTTATTTT
  CCAAAAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005709 unedited
  NGTACGTCAGATTTGTATACGACTCACTATAGGCGGCCGCGATTCCGGCATAAGGTGGAT
  TTTCTGATTGAAAATGATGCAGAGAAGGACTATCTCTATGATGTGCTGCGAATGTACCAC
  CAGACCATGGACGTGGCCGTGCTCGTGGGAGACCTGAAGCTGGTCATCAATGAACCCAGC
  CGTCTGCCTCTGTTTGATGCCATTCGGCCGCTGATCCCACTGAAGCACCAGGTGGAATAT
  GATCAGCTGACCCCCCGGCGCTCCAGGAAGCTGAAGGAGGTGCGTCTGGACCGTCTGCAC
  CCCGAAGGCCTCGGCCTGAGTGTGCGTGGTGGCCTGGAGTTTGGCTGTGGGCTCTTCATC
  TCCCACCTCATCAAAGGCGGTCAGGCAGACAGCGTCGGGCTCCAGGTAGGGGACGAGATC
  GTCCGGATCAATGGATATTCCATCTCCTCCTGTACCCATGAGGAGGTCATCAACCTCATT
  CGAACCAAGAAAACTGTGTCCATCAAAGTGAGACACATCGGCCTGATCCCCGTGAAAAGC
  TCTCCTGATGAGCCCCTCACTTGGCAGTATGTGGATCAGTTTGTGTCGGAATCTGGGGGC
  GTGCGAGGCAGCCTGGGCTCCCCTGGAAATCGGGAAAACAAGGAGAAGAAGGTCTTCATC
  AGCCTGGTAGGCTCCCGAGGCCTTGGCTGCAGCATTTCCAGCGGCCCCATCCAGAAGCCT
  GGCATCTTTATCAGCCATGTGAAACCTGGCTCCCTGTCTGCTGAGGTGGGATTGGAGATA
  AGGGACCAGATTGTCGAAATCAATGGCGTCGACTTCTCTACCTGGATCACAAGGAGGGCC
  GGGAGCTGTTTATGACAAACCGGGAACGGCTGGCAAAAGCCCGCACCGTGACCTGCT
  
• Restriction Sites: Please inquire
• ACCN: NM_005709
• ORF Size: 1659 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_005709.2, NP_005700.2
• RefSeq Size: 2247
• RefSeq ORF: 1659
• Locus ID: 10083
• Gene Summary: This gene encodes a scaffold protein that functions in the assembly of Usher protein complexes. The protein contains PDZ domains, a coiled-coil region with a bipartite nuclear localization signal and a PEST degradation sequence. Defects in this gene are the cause of Usher syndrome type 1C and non-syndromic sensorineural deafness autosomal recessive type 18. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
  Transcript Variant: This variant (1) has multiple differences in the coding region, compared to variant b3, one of which results in a translational frameshift. The resulting protein (isoform a) has a distinct C-terminus and is shorter than isoform b3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.