KCNMB3 (NM_171828) Human Untagged Clone

CAT#: SC123922

KCNMB3 (untagged)-Human potassium large conductance calcium-activated channel, subfamily M beta member 3 (KCNMB3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KCNMB3
• Synonyms: BKBETA3; HBETA3; K(VCA)BETA-3; KCNMB2; KCNMBL; SLO-BETA-3; SLOBETA3
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC123922 sequence for NM_171828 edited (data generated by NextGen Sequencing)
  ATGCAGCCCTTCAGCATCCCCGTGCAAATCACACTTCAGGGCAGCCGGAGGCGCCAGGGG
  AGGACAGCCTTTCCTGCCTCAGGGAAGAAGAGAGAGACAGACTACAGTGATGGAGACCCA
  CTAGATGTGCACAAGAGGCTGCCATCCAGTACTGGAGAGGACCGAGCCGTGATGCTGGGG
  TTTGCCATGATGGGCTTCTCAGTCCTAATGTTCTTCTTGCTCGGAACAACCATTCTAAAG
  CCTTTTATGCTCAGCATTCAGAGAGAAGAATCGACCTGCACTGCCATCCACACAGATATC
  ATGGACGACTGGCTGGACTGTGCCTTCACCTGTGGTGTGCACTGCCACGGTCAGGGGAAG
  TACCCGTGTCTTCAGGTGTTTGTGAACCTCAGCCATCCAGGTCAGAAAGCTCTCCTACAT
  TATAATGAAGAGGCTGTCCAGATAAATCCCAAGTGCTTTTACACACCTAAGTGCCACCAA
  GATAGAAATGATTTGCTCAACAATGCTCTGGACATAAAAGAATTCTTCGATCACAAAAAT
  GGAACCCCCTTTTCATGCTTCTACAGTCCAGCCAGCCAATCTGAAGATGTCATTCTTATA
  AAAAAGTATGACCAAATGGCTATCTTCCACTGTTTATTTTGGCCTTCACTGACTCTGCTA
  GGTGGTGCCCTGATTGTTGGCATGGTGAGATTAACACAACACCTGTCCTTACTGTGTGAA
  AAATATAGCACTGTAGTCAGAGATGAGGTAGGTGGAAAAGTACCTTATATAGAACAGCAT
  CAGTTCAAACTGTGCATTATGAGGAGGAGCAAAGGAAGAGCAGAGAAATCTTAA
  
  Clone variation with respect to NM_171828.1
  151 g=>a;503 g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_171828 unedited
  CCACTCACTATATGGCGGCCGCGCAGCAGACCACGCAGGTCCTTCTTGATCATCTAGAAC
  TGACCGCTCCGCCTTGCCAGGAGTCTGCAGAACCACGTGGCTAGCCTGCCTGAAGTTCTC
  ACCTCTCCAGGAAGGCGGGGGGCTTCTAATGGCTGCAGCTGCGCTGGGGGCTGGGGGCTC
  CCGCTGGGACTCCACTTCCGTGGATGTCTAAGCTTCACCTTTCTTGCGCCCGCAGGGGCA
  TGACTCAGGTGAAAGGGAGCCATTTTCTCAGACCCCTGGCCTCATGCAGCCCTTCAGCAT
  CCCCGTGCAAATCACACTTCAGGGCAGCCGGAGGCGCCAGGGGAGGACAGCCTTTCCTGC
  CTCAGGGAAGAAGAGAGAGACAGACTACAGTGATGGAGACCCACTAGATGTGCACAAGAG
  GCTGCCATCCAGTACTGGAGAGGACCGAGCCGTGATGCTGGGGTTTGCCATGATGGGCTT
  CTCAGTCCTAATGTTCTTCTTGCTCGGAACAACCATTCTAAAGCCTTTTATGCTCAGCAT
  TCAGAGAGAAGAATCGACCTGCACTGCCATCCACACAGATATCATGGACGACTGGCTGGA
  CTGTGCCTTCACCTGTGGTGTGCACTGCCACGGTCAGGGGAAGTACCCGTGTCTTCAGGT
  GTTTGTGAACCTCAGCCATCCAGGTCAGAAAGCTCTCCTACATTATAATGAAGAGGCTGT
  CCAGATAAATCCCAAGTGCTTTTACACACCTAAGTGCN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_171828 unedited
  TCCGGGCCAGGATAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTCAGG
  AAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTGGTTTTTTTTTTTTTT
  TTTTAAATTTTTTCCCACATGAAAATATGATACTTTAATTATTACCTTTTACATTGTTAG
  TTTGCAGACAGGCATAATTAGGTCCTCAGTTGCAGAAATCACAGACATCTGAAGGCCAGC
  ACTTTAATTTGGCCACCGTCTTAAGATTTCTCTGCTCTTCCTTTGCTCCTCCTCATAATG
  CACAGTTTGAACTGATGCTGTTCTATATAAGGTACTTTTCCACCTACCTCATCTCTGACT
  ACAGTGCTATATTTTTCACACAGTAAGGACAGGTGTTGTGTTAATCTCACCATGCCAACA
  ATCAGGGCACCACCTAGCAGAGTCAGTGAAGGCCAAAATAAACAGTGGAAGATAGCCATT
  TGGTCATACTTTTTTATAAGAATGACATCTTCAGATTGGCTGGCTGGACTGTAGAAGCAT
  GAAAAGGGGGTTCCATTTTTGTGATCGAAGAATTCTTTTATGTCCAGAGCATTGTTGAGC
  AAATCATTTCTATCTTGGTGGCACTTAGGTGTGTAAAAGCACTTGGGATTTATCTGGACA
  GCCTCTTCATTATAATGTAGGAGAGCTTTCTGACCTGGATGGCTGAGGTTCACAAACACC
  TGAAGACACGGGTACTTCCCCTGACCGTGGCAGTGCAC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_171828
• ORF Size: 834 bp
• Insert Size: 6200
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_171828.1, NP_741979.1
• RefSeq Size: 1272
• RefSeq ORF: 834
• Locus ID: 27094
• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• Protein Pathways: Vascular smooth muscle contraction
• Gene Summary: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]
  Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region, and uses an alternate translational start codon, compared to variant 4. The resulting isoform (a) has a distinct N-terminus and is shorter than isoform d. CCDS Note: This CCDS representation is supported by accession AF204159.1 and data in PMID:10766764.