Gremlin 1 (GREM1) (NM_013372) Human Untagged Clone

CAT#: SC123968

GREM1 (untagged)-Human gremlin 1 (GREM1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: GREM1
• Synonyms: C15DUPq; CKTSF1B1; CRAC1; CRCS4; DAND2; DRM; DUP15q; GREMLIN; HMPS; HMPS1; IHG-2; MPSH; PIG2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC123968 sequence for NM_013372 edited (data generated by NextGen Sequencing)
  ATGAGCCGCACAGCCTACACGGTGGGAGCCCTGCTTCTCCTCTTGGGGACCCTGCTGCCG
  GCTGCTGAAGGGAAAAAGAAAGGGTCCCAAGGTGCCATCCCCCCGCCAGACAAGGCCCAG
  CACAATGACTCAGAGCAGACTCAGTCGCCCCAGCAGCCTGGCTCCAGGAACCGGGGGCGG
  GGCCAAGGGCGGGGCACTGCCATGCCCGGGGAGGAGGTGCTGGAGTCCAGCCAAGAGGCC
  CTGCATGTGACGGAGCGCAAATACCTGAAGCGAGACTGGTGCAAAACCCAGCCGCTTAAG
  CAGACCATCCACGAGGAAGGCTGCAACAGTCGCACCATCATCAACCGCTTCTGTTACGGC
  CAGTGCAACTCTTTCTACATCCCCAGGCACATCCGGAAGGAGGAAGGTTCCTTTCAGTCC
  TGCTCCTTCTGCAAGCCCAAGAAATTCACTACCATGATGGTCACACTCAACTGCCCTGAA
  CTACAGCCACCTACCAAGAAGAAGAGAGTCACACGTGTGAAGCAGTGTCGTTGCATATCC
  ATCGATTTGGATTAA
  
  Clone variation with respect to NM_013372.6
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_013372 unedited
  GTACAATGTGAATACCACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGCGACCCAG
  TGCACGGCCGCCGCGTCACTCTCGGTTCCGCTGACCCCGCGCCGAGCCCCGGCGGCTGTG
  GCCGCGGCCGCACTCAGCGCCACGCGTCGAAAGCGCAGGCCCCGAGGACCCGCCGCACTG
  ACAGTATGAGCCGCACAGCCTACACGGTGGGAGCCCTGCTTCTCCTCTTGGGGACCCTGC
  TGCCGGCTGCTGAAGGGAAAAAGAAAGGGTCCCAAGGTGCCATCCCCCCGCCAGACAAGG
  CCCAGCACAATGACTCAGAGCAGACTCAGTCGCCCCAGCAGCCTGGCTCCAGGAACCGGG
  GGCGGGGCCAAGGGCGGGGCACTGCCATGCCCGGGGAGGAGGTGCTGGAGTCCAGCCAAG
  AGGCCCTGCATGTGACGGAGCGCAAATACCTGAAGCGAGACTGGTGCAAAACCCAGCCGC
  TTAAGCAGACCATCCACGAGGAAGGCTGCAACAGTCGCACCATCATCAACCGCTTCTGTT
  ACGGCCAGTGCAACTCTTTCTACATCCCCAGGCACATCCGGAAGGAGGAAGGTTCCTTTC
  AGTCCTGCTCCTTCTGCAAGCCCAAGAAATTCACTACCATGATGGTCACACTCAACTGCC
  CTGGACTACAGCCACCTACCAAGAGAAGAGAGTCACACGTGTGAAGCAGTGTCGTTGCAT
  ATCCATCGATTTGGATAA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_013372 unedited
  GCCTGCAGTGGCAACTTCCGGGCCAGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCAC
  CCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTG
  GTTTTTTTTTTTTTTTTTTTTTGTTTTTTTGGGGTTTTTTCTTTTAATGCCCAGCACAAA
  GTGTACATCATAAAATTCATATTTGGTGTTTGGCATTATTTTAATAAGTTTGATCAAAAC
  CACAAATTTCTTGCCATAAAAATATTCTACTATAATAATGAAAAAATATTTCATTACCTC
  ATCCGTGACTCGAATAAAATATGGTATAAATATGGCATTTTCAATGAAAGTTGGAAAACA
  CACCACATTTGTACTAGTCTTAATATAGGCCCAGTAAGAAAAACAAATATTTCCCTCTTT
  GGCTAGTGATATGCTTTTAGGGTAGTTACCCTGCTGATTATCCCAGTGAAGTTAGTGTTG
  AGGAAATTCTCTTTACTTGAGCCAAATCTGCACTTATGTGCAAGACTGTGGTACAAGCTC
  CTAAAAGAAGATTACTGCTGCCAACTTAAGTCATCTCCATTAACGAAATTGCATTCTTGT
  GGCAGAGTTTAAACAACCAGAGAAATTCAATGTTTGCTGGTTCTGAATGTCATTTTTCCT
  CCCTGGTGTGGTTTTACATTTTCAGCTTCTTTCCCTTTTCTTTCTCCCACCCTCAAAATT
  CTGCCTTAACATTTGTGTGG
  
• Restriction Sites: Please inquire
• ACCN: NM_013372
• ORF Size: 555 bp
• Insert Size: 3500
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_013372.5, NP_037504.1
• RefSeq Size: 4175
• RefSeq ORF: 555
• Locus ID: 26585
• Protein Families: ES Cell Differentiation/IPS, Secreted Protein
• Gene Summary: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.