KCNH2 (NM_172056) Human Untagged Clone

CAT#: SC123979

KCNH2 (untagged)-Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KCNH2
• Synonyms: ERG-1; ERG1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_172056, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCCGGTGCGGAGGGGCCACGTCGCGCCGCAGAACACCTTCCTGGACACCATCATCCGCAAGTTTGAGG
  GCCAGAGCCGTAAGTTCATCATCGCCAACGCTCGGGTGGAGAACTGCGCCGTCATCTACTGCAACGACGG
  CTTCTGCGAGCTGTGCGGCTACTCGCGGGCCGAGGTGATGCAGCGACCCTGCACCTGCGACTTCCTGCAC
  GGGCCGCGCACGCAGCGCCGCGCTGCCGCGCAGATCGCGCAGGCACTGCTGGGCGCCGAGGAGCGCAAAG
  TGGAAATCGCCTTCTACCGGAAAGATGGGAGCTGCTTCCTATGTCTGGTGGATGTGGTGCCCGTGAAGAA
  CGAGGATGGGGCTGTCATCATGTTCATCCTCAATTTCGAGGTGGTGATGGAGAAGGACATGGTGGGGTCC
  CCGGCTCATGACACCAACCACCGGGGCCCCCCCACCAGCTGGCTGGCCCCAGGCCGCGCCAAGACCTTCC
  GCCTGAAGCTGCCCGCGCTGCTGGCGCTGACGGCCCGGGAGTCGTCGGTGCGGTCGGGCGGCGCGGGCGG
  CGCGGGCGCCCCGGGGGCCGTGGTGGTGGACGTGGACCTGACGCCCGCGGCACCCAGCAGCGAGTCGCTG
  GCCCTGGACGAAGTGACAGCCATGGACAACCACGTGGCAGGGCTCGGGCCCGCGGAGGAGCGGCGTGCGC
  TGGTGGGTCCCGGCTCTCCGCCCCGCAGCGCGCCCGGCCAGCTCCCATCGCCCCGGGCGCACAGCCTCAA
  CCCCGACGCCTCGGGCTCCAGCTGCAGCCTGGCCCGGACGCGCTCCCGAGAAAGCTGCGCCAGCGTGCGC
  CGCGCCTCGTCGGCCGACGACATCGAGGCCATGCGCGCCGGGGTGCTGCCCCCGCCACCGCGCCACGCCA
  GCACCGGGGCCATGCACCCACTGCGCAGCGGCTTGCTCAACTCCACCTCGGACTCCGACCTCGTGCGCTA
  CCGCACCATTAGCAAGATTCCCCAAATCACCCTCAACTTTGTGGACCTCAAGGGCGACCCCTTCTTGGCT
  TCGCCCACCAGTGACCGTGAGATCATAGCACCTAAGATAAAGGAGCGAACCCACAATGTCACTGAGAAGG
  TCACCCAGGTCCTGTCCCTGGGCGCCGACGTGCTGCCTGAGTACAAGCTGCAGGCACCGCGCATCCACCG
  CTGGACCATCCTGCATTACAGCCCCTTCAAGGCCGTGTGGGACTGGCTCATCCTGCTGCTGGTCATCTAC
  ACGGCTGTCTTCACACCCTACTCGGCTGCCTTCCTGCTGAAGGAGACGGAAGAAGGCCCGCCTGCTACCG
  AGTGTGGCTACGCCTGCCAGCCGCTGGCTGTGGTGGACCTCATCGTGGACATCATGTTCATTGTGGACAT
  CCTCATCAACTTCCGCACCACCTACGTCAATGCCAACGAGGAGGTGGTCAGCCACCCCGGCCGCATCGCC
  GTCCACTACTTCAAGGGCTGGTTCCTCATCGACATGGTGGCCGCCATCCCCTTCGACCTGCTCATCTTCG
  GCTCTGGCTCTGAGGAGCTGATCGGGCTGCTGAAGACTGCGCGGCTGCTGCGGCTGGTGCGCGTGGCGCG
  GAAGCTGGATCGCTACTCAGAGTACGGCGCGGCCGTGCTGTTCTTGCTCATGTGCACCTTTGCGCTCATC
  GCGCACTGGCTAGCCTGCATCTGGTACGCCATCGGCAACATGGAGCAGCCACACATGGACTCACGCATCG
  GCTGGCTGCACAACCTGGGCGACCAGATAGGCAAACCCTACAACAGCAGCGGCCTGGGCGGCCCCTCCAT
  CAAGGACAAGTATGTGACGGCGCTCTACTTCACCTTCAGCAGCCTCACCAGTGTGGGCTTCGGCAACGTC
  TCTCCCAACACCAACTCAGAGAAGATCTTCTCCATCTGCGTCATGCTCATTGGCTCCCTCATGTATGCTA
  GCATCTTCGGCAACGTGTCGGCCATCATCCAGCGGCTGTACTCGGGCACAGCCCGCTACCACACACAGAT
  GCTGCGGGTGCGGGAGTTCATCCGCTTCCACCAGATCCCCAATCCCCTGCGCCAGCGCCTCGAGGAGTAC
  TTCCAGCACGCCTGGTCCTACACCAACGGCATCGACATGAACGCGGTGCTGAAGGGCTTCCCTGAGTGCC
  TGCAGGCTGACATCTGCCTGCACCTGAACCGCTCACTGCTGCAGCACTGCAAACCCTTCCGAGGGGCCAC
  CAAGGGCTGCCTTCGGGCCCTGGCCATGAAGTTCAAGACCACACATGCACCGCCAGGGGACACACTGGTG
  CATGCTGGGGACCTGCTCACCGCCCTGTACTTCATCTCCCGGGGCTCCATCGAGATCCTGCGGGGCGACG
  TCGTCGTGGCCATCCTGGGTATGGGGTGGGGGGCGGGCACTGGACTGGAAATGCCCTCTGCAGCCTCAAG
  AGGTGCGAGCCTTCTGAATATGCAGTCACTGGGGCTGTGGACCTGGGACTGCCTGCAGGGTCACTGGGCT
  CCTTTAATTCACCTAAACTCAGGCCCTCCAAGCGGGGCCATGGAGAGGAGCCCCACGTGGGGTGAGGCTG
  CTGAACTCTGGGGTTCCCACATTCTCCTTCCCTTCAGGATCCGCCACAAACAGACACTTTTTGCTTCCTT
  AAAGTAG
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_172056 unedited
  TCAAATTTTGTAATACGACTTCACTATAGGGCGGCCGCGAATTCGCACGAGGGCCCGCCC
  GGCCCGCCCATGGGCTCAGGATGCCGGTGCGGAGGGGCCACGTCGCGCCGCAGAACACCT
  TCCTGGACACCATCATCCGCAAGTTTGAGGGCCAGAGCCGTAAGTTCATCATCGCCAACG
  CTCGGGTGGAGAACTGCGCCGTCATCTACTGCAACGACGGCTTCTGCGAGCTGTGCGGCT
  ACTCGCGGGCCGAGGTGATGCAGCGACCCTGCACCTGCGACTTCCTGCACGGGCCGCGCA
  CGCAGCGCCGCGCTGCCGCGCAGATCGCGCAGGCACTGCTGGGCGCCGAGGAGCGCAAAG
  TGGAAATCGCCTTCTACCGGAAAGATGGGAGCTGCTTCCTATGTCTGGTGGATGTGGTGC
  CCGTGAAGAACGAGGATGGGGCTGTCATCATGTTCATCCTCAATTTCGAGGTGGTGATGG
  AGAAGGACATGGTGGGGGTCCCNNNCTTNTGATCCCCNCCCCCCCCGGGCCCCCCCCCCC
  CNNCTGGGCTGGCGCCCGGGGCCGCTGCCNTTGTCCCTTTCTCCTGGTGTCTGCCCCGCG
  CCTTTTGGGCTCTTGACTGGCCCGGGGGGCTNTTTCGGTCTCGTTCTGGTCTGGGNTCCG
  CTCGGTCTCGTCTCCCCTCCTCCGGCCCCTGTGGGGTCGGGCCGCGTGTTCTTTGCTCGC
  TCCCGGTCCCCCCTTGTGGTTGGTTCGTCGCGCCTCGTTTTGTAGNCGCGTGGCCCTTGT
  GCTTCACCTTCTTGTGTTGGGCCTCTGTCTCTCGCTGTGTGTACCCGGGGGTGGGCGTTG
  TGTGTTGCNGGCGTGCTGCGTCTCCCTCGTTTGCGGCCCGGTCGCCTGTCGCTGTGGTTT
  GTGGCGTGTCGTAGCTCTCGTTCCCGTTAATCTCTTGTGGCGTTCGTGTTGACTGATTAT
  TGCCGCGCTCGGTCCTAGGTCATATGCGTTAGACTTAGTACACGTACTAACGCATTGCGG
  AATGTGATAGTGATAGAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_172056 unedited
  GAACATGATGACAGCCCCATCCTCGTTCTTCACGGGCACCACATCCACCAGACATAGGAA
  GCAGCTCCCATCTTTCCGGTAGAAGGCGATTTCCACTTTGCGCTCCTCGGCGCCCAGCAG
  TGCCTGCGCGATCTGCGCGGCAGCGCGGCGCTGCGTGCGCGGCCCGTGCAGGAAGTCGCA
  GGTGCAGGGTCGCTGCATCACCTCGGCCCGCGAGTAGCCGCACAGCTCGCAGAAGCCGTC
  GTTGCAGTAGATGACGGCGCAGTTCTCCACCCGAGCGTTGGCGATGATGAACTTACGGCT
  CTGGCCCTCAAACTTGCGGATGATGGTGTCCAGGAAGGTGTTCTGCGGCGCGACGTGGCC
  CCTCCGCACCGGCATCCTGAGCCCATGGGCGGGCCGGGCGGGCCCTCGTGCCGAATTCGC
  GGCCGCCCTATAGTGAGTCGTATTACAAAATTCTGACGGTTCACTAAACGAGCTCTGCTT
  ATATAGACCTCCCACCGTACACGCCTACCGCCCATTTGCGTCAACGGGGCGGGGTTATTA
  CGACATTTTGGAAAGTCCCGTTGATTTTGGTGCCAAAACAAACTCCCATTGACGTCAAAT
  GGGGTGGAGACTTTGGAAATCCCCGTGAGTCAAACCGCTATCCACGCCCCATTGTGTACT
  GCCAAAACCGCATCACCATGGGTATAGCGATTACCTAATCCTTAAAGTTCCGGCAATTAG
  GAAAATCCCCCATAGGATGTGCCGTGCCTAAATGCCGGCGGGCAATTTTCCCGTTTTGGC
  CTAAAATGGGGGGGGCC
  
• Restriction Sites: Please inquire
• ACCN: NM_172056
• Insert Size: 3600 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_172056.1, NP_742053.1
• RefSeq Size: 3164 bp
• RefSeq ORF: 2667 bp
• Locus ID: 3757
• Cytogenetics: 7q36.1
• Protein Families: Druggable Genome, Ion Channels: Potassium, Transcription Factors, Transmembrane
• Gene Summary: 'This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]'
  Transcript Variant: This variant (2), also known as HERG-USO, differs in the 3' UTR and 3' coding region compared to variant 1, resulting in a shorter isoform (b) with a different C-terminus compared to isoform a.