CACNB2 (NM_000724) Human Untagged Clone

CAT#: SC124059

CACNB2 (untagged)-Human calcium channel, voltage-dependent, beta 2 subunit (CACNB2), transcript variant 1


  "NM_000724" in other vectors (6)

Reconstitution Protocol

USD 1,030.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CACNB2
Synonyms CAB2; CACNLB2; CAVB2; MYSB
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC124059 sequence for NM_000724 edited (data generated by NextGen Sequencing)
ATGCAGTGCTGCGGGCTGGTGCATCGCCGGCGAGTACGGGTGTCCTATGGTTCGGCAGAC
TCCTACACTAGCCGTCCATCCGATTCCGATGTATCTCTGGAGGAGGACCGGGAGGCAGTG
CGCAGAGAAGCGGAGCGGCAGGCCCAGGCACAGTTGGAAAAAGCAAAGACAAAGCCCGTT
GCATTTGCGGTTCGGACAAATGTCAGCTACAGTGCGGCCCATGAAGATGATGTTCCAGTG
CCTGGCATGGCCATCTCATTCGAAGCAAAAGATTTTCTGCATGTTAAGGAAAAATTTAAC
AATGACTGGTGGATAGGGCGATTGGTAAAAGAAGGCTGTGAAATCGGATTCATTCCAAGC
CCAGTCAAACTAGAAAACATGAGGCTGCAGCATGAACAGAGAGCCAAGCAAGGGAAATTC
TACTCCAGTAAATCAGGAGGAAATTCATCATCCAGTTTGGGTGACATAGTACCTAGTTCC
AGAAAATCAACACCTCCATCATCTGCTATAGACATAGATGCTACTGGCTTAGATGCAGAA
GAAAATGATATTCCAGCAAACCACCGCTCCCCTAAACCCAGTGCAAACAGTGTAACGTCA
CCCCACTCCAAAGAGAAAAGAATGCCCTTCTTTAAGAAGACAGAGCACACTCCTCCGTAT
GATGTGGTACCTTCCATGCGACCAGTGGTCCTAGTGGGCCCTTCTCTGAAGGGCTACGAG
GTCACAGATATGATGCAAAAAGCGCTGTTTGATTTTTTAAAACACAGATTTGAAGGGCGG
ATATCCATCACAAGGGTCACCGCTGACATCTCGCTTGCCAAACGCTCGGTATTAAACAAT
CCCAGTAAGCACGCAATAATAGAAAGATCCAACACAAGGTCAAGCTTAGCGGAAGTTCAG
AGTGAAATCGAAAGGATTTTTGAACTTGCAAGAACATTGCAGTTGGTGGTCCTTGACGCG
GATACAATTAATCATCCAGCTCAACTCAGTAAAACCTCCTTGGCCCCTATTATAGTATAT
GTAAAGATTTCTTCTCCTAAGGTTTTACAAAGGTTAATAAAATCTCGAGGGAAATCTCAA
GCTAAACACCTCAACGTCCAGATGGTAGCAGCTGATAAACTGGCTCAGTGTCCTCCAGAG
CTGTTCGATGTGATCTTGGATGAGAACCAGCTTGAGGATGCCTGTGAGCACCTTGCCGAC
TATCTGGAGGCCTACTGGAAGGCCACCCATCCTCCCAGCAGTAGCCTCCCCAACCCTCTC
CTTAGCCGTACATTAGCCACTTCAAGTCTGCCTCTTAGCCCCACCCTAGCCTCTAATTCA
CAGGGTTCTCAAGGTGATCAGAGGACTGATCGCTCCGCTCCTATCCGTTCTGCTTCCCAA
GCTGAAGAAGAACCTAGTGTGGAACCAGTCAAGAAATCCCAGCACCGCTCTTCCTCCTCA
GCCCCACACCACAACCATCGCAGTGGGACAAGTCGCGGCCTCTCCAGGCAAGAGACATTT
GACTCGGAAACCCAGGAGAGTCGAGACTCTGCCTACGTAGAGCCAAAGGAAGATTATTCC
CATGACCACGTGGACCACTATGCCTCACACCGTGACCACAACCACAGAGACGAGACCCAC
GGGAGCAGTGACCACAGACACAGGGAGTCCCGGCACCGTTCCCGGGACGTGGATCGAGAG
CAGGACCACAACGAGTGCAACAAGCAGCGCAGCCGTCATAAATCCAAGGATCGCTACTGT
GAAAAGGATGGAGAAGTGATATCAAAAAAACGGAATGAGGCTGGGGAGTGGAACAGGGAT
GTTTACATCCGCCAATGA

Clone variation with respect to NM_000724.3
>OriGene 5' read for NM_000724 unedited
GGCGCGATACATTCTGACACCGGACAAATCAAATTGCCCAAAAGTTACAGAGGTAACAGT
GAATCCAGGATGCTGCTATCAGCCTGTGCATTGTGAAGAAGGCAATCATAGGCGAGCAGC
CGCGGGAGCAGGAACAGCAGCGTGCTAAGAAGCAGTCACATAAACAGCAGCAGGAGTATG
TTTTCTGCTTTTCAAAAGCAGAGTACTGCAGGGTCGCGAAATGCAAGACACTCAGATGTT
TGAAAATCTCCCGAGTTGAGAATGGCTACTGTAAAAGCGTCACCAAGAAACTCTGACGAT
CTGGACAGTCCTAACTCTGTGTTAGCAATACTTACTTCCGGAAAATTAATGCTACTTCTT
GTAGATTTTTGCAAATAGGAAACCCCCTTGAAGAAGATCTCAAATTACGCCCCCCACCCC
CAAAAAAAGACAAACAGGGGAGAACAAAGTTTTGGCATGCCTGCAGGAACGGTGGCTTTT
TTAGAAACTACCTAGGAGGCAGAAGCTAAGTGATTTGCTCATGCCTCTTACCTGGGAGTA
GAAGGTGGGAAGAAATGGACCGAGGCTGTGACGAGAAGACAAGGCACAGTGCAGCTTGGT
GAAGCCACACGCTGACTGCGTTCTGCCCCCTCTTCATGCAGTGCTGCGGGCTGGTGCATC
GCCGGCGAGTACGGGTGTCCTATGGTTCGGCAGACTCCTACACTAGCCGTCCATCCGATT
CCGATGTATTTCTGGAGGAGGACCGGGAGGCAGTGCGCATAGAACCGGAGCGGCAGGCCC
AGGCCAGTTGGTAAAAGCAAAGACCAACCCGTTGGCATTGCGGTTCGGACAAATGTCAGC
TACCGTGCGGCCT
>OriGene 3' read for NM_000724 unedited
CCAGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTCAGGAAACAG
CTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGAAGTGGGAGAA
GTTATAAAAATTTATTTTCCCACGAAATAATTCCACAAGCTGTGTAAACAAACATTTCTT
ACTAAAACAAATACTCTAACACACAAAGATTGTACATTTCCAGTGAAACACTCACAGTAA
AATTGCCTGTATTTTCACTCTCTAGGAGCAAAAACAAGGAGGCAGCAGATGAATGCTTTC
CTAGTTACCTTTGGCAGCAAGCTTACTCACATTCCCTGACTGCTCAATGGGTTGTTAAAG
CAACATATAGCACAATTAATTAAATACCGGACCGAGGTGGGCAGAATGCTCGATATCAGT
CTCTAGTTTCTTCGTTAGTCTTCAGCATTCCAATTCATCTCAACCATTCAGTCACTCGGT
GCACACTTTCTTACATACGGACACACACACGTGCATATAGCGAGTTCCGGCTCGTAGACT
CCAGTGCAGTGACTAGAACAGACACTAGCTACTAAGAATGTGTCACAATCAGTGTGAACT
GTATGGAGTAGAACAACCTCTGGAGTTNTATATTTACCATAATTTATGGTGGAAATTACA
AACTTACTTANCAGGATGGTATAACATTCAGAATTCAAACCTTTTTCAGTCAAGCAATCA
CCCATATTACAGTATGTACACACTTTCTACTAGATTGAGGAAGT
Restriction Sites NotI-NotI     
ACCN NM_000724
Insert Size 4200 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000724.2, NP_000715.1
RefSeq Size 3721 bp
RefSeq ORF 1818 bp
Locus ID 783
Cytogenetics 10p12.33-p12.31
Domains Ca_channel_B, SH3, GuKc
Protein Families Druggable Genome, Ion Channels: Other
Protein Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway
Gene Summary 'This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]'
Transcript Variant: This variant (1) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 2. These differences cause translation initiation at an alternate start codon, and result in an isoform (1) with a shorter and distinct N-terminus, compared to isoform 2.

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