IL12B (NM_002187) Human Untagged Clone

CAT#: SC124116

IL12B (untagged)-Human interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B)


  "NM_002187" in other vectors (6)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

Product Images

Other products for "IL12B"

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol IL12B
Synonyms CLMF; CLMF2; IL-12B; IMD28; IMD29; NKSF; NKSF2
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC124116 sequence for NM_002187 edited (data generated by NextGen Sequencing)
ATGTGTCACCAGCAGTTGGTCATCTCTTGGTTTTCCCTGGTTTTTCTGGCATCTCCCCTC
GTGGCCATATGGGAACTGAAGAAAGATGTTTATGTCGTAGAATTGGATTGGTATCCGGAT
GCCCCTGGAGAAATGGTGGTCCTCACCTGTGACACCCCTGAAGAAGATGGTATCACCTGG
ACCTTGGACCAGAGCAGTGAGGTCTTAGGCTCTGGCAAAACCCTGACCATCCAAGTCAAA
GAGTTTGGAGATGCTGGCCAGTACACCTGTCACAAAGGAGGCGAGGTTCTAAGCCATTCG
CTCCTGCTGCTTCACAAAAAGGAAGATGGAATTTGGTCCACTGATATTTTAAAGGACCAG
AAAGAACCCAAAAATAAGACCTTTCTAAGATGCGAGGCCAAGAATTATTCTGGACGTTTC
ACCTGCTGGTGGCTGACGACAATCAGTACTGATTTGACATTCAGTGTCAAAAGCAGCAGA
GGCTCTTCTGACCCCCAAGGGGTGACGTGCGGAGCTGCTACACTCTCTGCAGAGAGAGTC
AGAGGGGACAACAAGGAGTATGAGTACTCAGTGGAGTGCCAGGAGGACAGTGCCTGCCCA
GCTGCTGAGGAGAGTCTGCCCATTGAGGTCATGGTGGATGCCGTTCACAAGCTCAAGTAT
GAAAACTACACCAGCAGCTTCTTCATCAGGGACATCATCAAACCTGACCCACCCAAGAAC
TTGCAGCTGAAGCCATTAAAGAATTCTCGGCAGGTGGAGGTCAGCTGGGAGTACCCTGAC
ACCTGGAGTACTCCACATTCCTACTTCTCCCTGACATTCTGCGTTCAGGTCCAGGGCAAG
AGCAAGAGAGAAAAGAAAGATAGAGTCTTCACGGACAAGACCTCAGCCACGGTCATCTGC
CGCAAAAATGCCAGCATTAGCGTGCGGGCCCAGGACCGCTACTATAGCTCATCTTGGAGC
GAATGGGCATCTGTGCCCTGCAGTTAG

Clone variation with respect to NM_002187.2
>OriGene 5' read for NM_002187 unedited
CGCGGAAAGTCAGGATTTGTATCACGATCTCATATAGGCGGCCGCCAGTGTGATGGATAT
CTGCAGAATTCGGCTTCAGAGCAAGATGTGTCACCAGCAGTTGGTCATCTCTTGGTTTTC
CCTGGTTTTTCTGGCATCTCCCCTCGTGGCCATATGGGAACTGAAGAAAGATGTTTATGT
CGTAGAATTGGATTGGTATCCGGATGCCCCTGGAGAAATGGTGGTCCTCACCTGTGACAC
CCCTGAAGAAGATGGTATCACCTGGACCTTGGACCAGAGCAGTGAGGTCTTAGGCTCTGG
CAAAACCCTGACCATCCAAGTCAAAGAGTTTGGAGATGCTGGCCAGTACACCTGTCACAA
AGGAGGCGAGGTTCTAAGCCATTCGCTCCTGCTGCTTCACAAAAAGGAAGATGGAATTTG
GTCCACTGATATTTTAAAGGACCAGAAAGAACCCAAAAATAAGACCTTTCTAAGATGCGA
GGCCAAGAATTATTCTGGACGTTTCACCTGCTGGTGGCTGACGACAATCAGTACTGATTT
GACATTCAGTGTCAAAAGCAGCAGAGGCTCTTCTGACCCCCAAGGGGTGACGTGCGGAGC
TGCTACACTCTCTGCAGAGAGAGTCAGAGGGGACAACAAGGAGTATGAGTACTCAGTGGA
GTGCCAGGAGGACAGTGCCTGCCCAGCTGCTGAGGAGAGTCTGCCCATTGAGGTCATGGT
TGGATGCCGTTCACAAGCTCAAGTATGAAAACTACACCCGCAGCTTCTTCATCAGGGACA
TCATCAAACCTGACCCACCCAAGAACTTGCAGCTGGAAGCCATTAAGGATTTCTCGCCGG
TGGGAGGTCACCTTGGAAGTACCCTGACACCTG
>OriGene 3' read for NM_002187 unedited
TGGGGNAGGGNNNNATGCACTGCATTCAACTTCCAGGCCGNANAACACTGGGGAGGGGTC
ACAGGGATGCCACCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAG
TCGACAAGCTTGATATCGGTACCGAGCTCGGATCCACTAGTAACGGCCGCCAGTGTGCTG
GAATTCGGCTTTTTCATCCTGGATCAGAACCTAACTGCAGGGCACAGATGCCCATTCGCT
CCAAGATGAGCTATAGTAGCGGTCCTGGGCCCGCACGCTAATGCTGGCATTTTTGCGGCA
GATGACCGTGGCTGAGGTCTTGTCCGTGAAGACTCTATCTTTCTTTTCTCTCTTGCTCTT
GCCCTGGACCTGAACGCAGAATGTCAGGGAGAAGTAGGAATGTGGAGTACTCCAGGTGTC
AGGGTACTCCCAGCTGACCTCCACCTGCCGAGAATTCTTTAATGGCTTCAGCTGCAAGTT
CTTGGGTGGGTCAGGTTTGATGATGTCCCTGATGAAGAAGCTGCTGGTGTAGTTTTCATA
CTTGAGCTTGTGAACGGCATCCACCATGACCTCAATGGGCAGACTCTCCTCAGCAGCTGG
GCAGGCACTGTCCTCCTGGCACTCCACTGAGTACTCATACTCCTTGTTGTCCCCTCTGAC
TCTCTCTGCAGAGAGTGTAGCAGCTCCGCACGTCACCCCTTTGGGGTCAGAAGAGCCTCT
GCTGCTTTGACACTGAATGTCAAATCAGTACTGATTTGCGTCAGCCACCAGCAGGTGAAA
CGTCCAGAATAATTCTTGGCTN
Restriction Sites Please inquire     
ACCN NM_002187
Insert Size 1100 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_002187.2, NP_002178.2
RefSeq Size 2347 bp
RefSeq ORF 987 bp
Locus ID 3593
Cytogenetics 5q33.3
Domains FN3
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Allograft rejection, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus
Gene Summary 'This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]'

Other Versions

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.