Ribonuclease A (RNASE1) (NM_198234) Human Untagged Clone

CAT#: SC124285

RNASE1 (untagged)-Human ribonuclease, RNase A family, 1 (pancreatic) (RNASE1), transcript variant 2


  "NM_198234" in other vectors (4)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol RNASE1
Synonyms RAC1; RIB1; RNS1
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_198234, the custom clone sequence may differ by one or more nucleotides


ATGGCTCTGGAGAAGTCTCTTGTCCGGCTCCTTCTGCTTGTCCTGATACTGCTGGTGCTGGGCTGGGTCC
AGCCTTCCCTGGGCAAGGAATCCCGGGCCAAGAAATTCCAGCGGCAGCATATGGACTCAGACAGTTCCCC
CAGCAGCAGCTCCACCTACTGTAACCAAATGATGAGGCGCCGGAATATGACACAGGGGCGGTGCAAACCA
GTGAACACCTTTGTGCACGAGCCCCTGGTAGATGTCCAGAATGTCTGTTTCCAGGAAAAGGTCACCTGCA
AGAACGGGCAGGGCAACTGCTACAAGAGCAACTCCAGCATGCACATCACAGACTGCCGCCTGACAAACGG
CTCCAGGTACCCCAACTGTGCATACCGGACCAGCCCGAAGGAGAGACACATCATTGTGGCCTGTGAAGGG
AGCCCATATGTGCCAGTCCACTTTGATGCTTCTGTGGAGGACTCTACCTAA


>OriGene 5' read for NM_198234 unedited
AATTCGGCACCAGCTTCCATCTCTCTCAGACACCAAGCTGCAGATCCAGGTCACCACCTA
GAGGGGAGGAAGACCTCGCTTTGGAGAGTGGGAATAAAACGCTCGTGGAAAAGGGTACAC
GCTTTTCTGGGAAAGTGAGGCCACCATGGCTCTGGAGAAGTCTCTTGTCCGGCTCCTTCT
GCTTGTCCTGATACTGCTGGTGCTGGGCTGGGTCCAGCCTTCCCTGGGCAAGGAATCCCG
GGCCAAGAAATTCCAGCGGCAGCATATGGACTCAGACAGTTCCCCCAGCAGCAGCTCCAC
CTACTGTAACCAAATGATGAGGCGCCGGAATATGACACAGGGGCGGTGCAAACCAGTGAA
CACCTTTGTGCACGAGCCCCTGGTAGATGTCCAGAATGTCTGTTTCCAGGAAAAGGTCAC
CTGCAAGAACGGGCAGGGCAACTGCTACAAGAGCAACTCCAGCATGCACATCACAGACTG
CCGCCTGACAAACGGCTCCAGGTACCCCAACTGTGCATACCGGACCAGCCCGAAGGAGAG
ACACATCATTGTGGCCTGTGAAGGGAGCCCATATGTGCCAGTCCACTTTGATGCTTCTGT
GGAGGACTCTACCTAAGGTCAGAGCAGCGAGATACCCCACCTCCCTCAACCTCATCCTCT
CCACAGCTGCCTCTTCCCTCTTCCTTCCCTGCTNGTGAAGAANGTACTACAGNTAGGGCT
CCTATTCACACACACATGCTTCCCTTTCCTGAGTCCCATCCCTGCGTGATT
Restriction Sites NotI-NotI     
ACCN NM_198234
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_198234.1, NP_937877.1
RefSeq Size 898 bp
RefSeq ORF 471 bp
Locus ID 6035
Cytogenetics 14q11.2
Protein Families Secreted Protein, Transmembrane
Gene Summary 'This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (2) contains an additional segment in the 5' UTR compared to variant 4. Variants 1, 2, 3 and 4 encode the same protein.

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