p53R2 (RRM2B) (NM_015713) Human Untagged Clone

CAT#: SC124337

RRM2B (untagged)-Human ribonucleotide reductase M2 B (TP53 inducible) (RRM2B), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RRM2B
• Synonyms: MTDPS8A; MTDPS8B; P53R2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC124337 sequence for NM_015713 edited (data generated by NextGen Sequencing)
  ATGGGCGACCCGGAAAGGCCGGAAGCGGCCGGGCTGGATCAGGATGAGAGATCATCTTCA
  GACACCAACGAAAGTGAAATAAAGTCAAATGAAGAGCCACTCCTAAGAAAGAGTTCTCGC
  CGGTTTGTCATCTTTCCAATCCAGTACCCTGATATTTGGAAAATGTATAAACAGGCACAG
  GCTTCCTTCTGGACAGCAGAAGAGGTCGACTTATCAAAGGATCTCCCTCACTGGAACAAG
  CTTAAAGCAGATGAGAAGTACTTCATCTCTCACATCTTAGCCTTTTTTGCAGCCAGTGAT
  GGAATTGTAAATGAAAATTTGGTGGAGCGCTTTAGTCAGGAGGTGCAGGTTCCAGAGGCT
  CGCTGTTTCTATGGCTTTCAAATTCTCATCGAGAATGTTCACTCAGAGATGTACAGTTTG
  CTGATAGACACTTACATCAGAGATCCCAAGAAAAGGGAATTTTTATTTAATGCAATTGAA
  ACCATGCCCTATGTTAAGAAAAAAGCAGATTGGGCCTTGCGATGGATAGCAGATAGAAAA
  TCTACTTTTGGGGAAAGAGTGGTGGCCTTTGCTGCTGTAGAAGGAGTTTTCTTCTCAGGA
  TCTTTTGCTGCTATATTCTGGCTAAAGAAGAGAGGTCTTATGCCAGGACTCACTTTTTCC
  AATGAACTCATCAGCAGAGATGAAGGACTTCACTGTGACTTTGCTTGCCTGATGTTCCAA
  TACTTAGTAAATAAGCCTTCAGAAGAAAGGGTCAGGGAGATCATTGTTGATGCTGTCAAA
  ATTGAGCAGGAGTTTTTAACAGAAGCCTTGCCAGTTGGCCTCATTGGAATGAATTGCATT
  TTGATGAAACAGTACATTGAGTTTGTAGCTGACAGATTACTTGTGGAACTTGGATTCTCA
  AAGGTTTTTCAGGCAGAAAATCCTTTTGATTTTATGGAAAACATTTCTTTAGAAGGAAAA
  ACAAATTTCTTTGAGAAACGAGTTTCAGAGTATCAGCGTTTTGCAGTTATGGCAGAAACC
  ACAGATAACGTCTTCACCTTGGATGCAGATTTTTAA
  
  Clone variation with respect to NM_015713.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_015713 unedited
  TGTATACGACTCACTATAGGGCGGCCGCGATTCGGCACGAGGGAGGAGCTCAGTTCCCTC
  AGCGCCCGTAGCTTCGGCGGAGTCTGCGCGATGGGCGACCCGGAAAGGCCGGAAGCGGCC
  GGGCTGGATCAGGATGAGAGATCATCTTCAGACACCAACGAAAGTGAAATAAAGTCAAAT
  GAAGAGCCACTCCTAAGAAAGAGTTCTCGCCGGTTTGTCATCTTTCCAATCCAGTACCCT
  GATATTTGGAAAATGTATAAACAGGCACAGGCTTCCTTCTGGACAGCAGAAGAGGTCGAC
  TTATCAAAGGATCTCCCTCACTGGAACAAGCTTAAAGCAGATGAGAAGTACTTCATCTCT
  CACATCTTAGCCTTTTTTGCAGCCAGTGATGGAATTGTAAATGAAAATTTGGTGGAGCGC
  TTTAGTCAGGAGGTGCAGGTTCCAGAGGCTCGCTGTTTCTATGGCTTTCAAATTCTCATC
  GAGAATGTTCACTCAGAGATGTACAGTTTGCTGATAGACACTTACATCAGAGATCCCAAG
  AAAAGGGAATTTTTATTTAATGCAATTGAAACCATGCCCTATGTTAAGAAAAAAGCAGAT
  TGGGCCTTGCGATGGATAGCAGATAGAAAATCTACTTTTGGGGAAAGAGTGGTGGCCTTT
  GCTGCTGTAGAAGGAGTTTTCTTCTCAGGATCTTTTGCTGCTATATTCTGGCTAAAGAAG
  AGAGGTCTTATGCCAGNACTCACTTTTNTCAATGAACTCATCAGCAGAGATGAANGGACT
  TCACTGTGACTTGCTTGCCCTGATGTCCANTACTTAGTANATAAAGCTTCAAAAGAAGGT
  CAGGNAGATCATTGNTGATGCTGTCAAAATGANCAGGGAGTTTTACCAGAGCCCTTGCCA
  GTTGGCTCATTGGAATGAATGCATTTGATGAACGTACAATTGAGTTGTACTGAAGATTAC
  TGTGA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_015713 unedited
  GCTATGGACCGGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAAGAATAAACATTCCCTTTATTAGGGGA
  GCCCTTGCCCTTATAAAAAAACCTTCCTCAAAAGGGAAAGGGCCAAAAGGGGGAAAATCC
  CATAGTTTTTTTCAACATCCTAAGCCAAAAAAATAAAAAAACACCTATTTTTTTTGAAAA
  AAAAACAAATTTTGTCCATGCAGGCTGGGTTTGATTGACCATAAGGTTTTTCAGCAAAAA
  AATTTTAAATCCCCCCCCCATAATAAAGCTTTTTTTGGCCCCAGAAAATAGAAAATAACT
  TTGCTAAAGGGCCAAACTTTTGAAAAAATGAAAACCCAGTTGGAAAACAAAGTTTGTAAA
  AATATTGGGACCTTTTTTAACTGGCCAAAAAGCAATTTTTTTTTCCAGCCTTCCATTTTA
  ACTTACATTTTTTTAAACAAGATTAAGCCCCAAATTGAGGGGATTAAACCCTTTTTTCCT
  AAGGCCCGGGGAATATGAAATTCTTTTTAAAATCTTTAACTTTTTACAAAGGAGCAGAGC
  CCTTAAGGGGAAAGGGGGGGAAACAAAAAAATTTCAATTTTGGGCCATTCATCCAGATTT
  TGGTGGGGAAGATTTCCCAAGGCCACTACCAATTCACTCAACTGGGTTAAAAAACATAAT
  ACCTGGATGGAAGGATTAATTGGGCTTTTATTTACCCCCATCTGCAGCTTTATCATTAAA
  AACAAGCTCCTGACCTTAGCCCCTTAANTCAGTATCTACAAAAGAAATTTGGGACTCCTA
  TGCACGGGGGTGTAGCCTATTTTAAGGTAAAAGGCAAATGGTTATATTTTAAATTGCCAC
  CGGCCACTTTCCCAAAATCAATCCTGCCCAATAAAAATGGGCATGAAAGCGAATATTGGG
  TGTTCTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_015713
• ORF Size: 1056 bp
• Insert Size: 5150
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_015713.3, NP_056528.2
• RefSeq Size: 4955
• RefSeq ORF: 1056
• Locus ID: 50484
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Glutathione metabolism, Metabolic pathways, p53 signaling pathway, Purine metabolism, Pyrimidine metabolism
• Gene Summary: This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
  Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.