TIGIT (NM_173799) Human Untagged Clone

CAT#: SC124474

TIGIT (untagged)-Human T cell immunoreceptor with Ig and ITIM domains (TIGIT)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TIGIT
• Synonyms: VSIG9; VSTM3; WUCAM
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC124474 sequence for NM_173799 edited (data generated by NextGen Sequencing)
  ATGCGCTGGTGTCTCCTCCTGATCTGGGCCCAGGGGCTGAGGCAGGCTCCCCTCGCCTCA
  GGAATGATGACAGGCACAATAGAAACAACGGGGAACATTTCTGCAGAGAAAGGTGGCTCT
  ATCATCTTACAATGTCACCTCTCCTCCACCACGGCACAAGTGACCCAGGTCAACTGGGAG
  CAGCAGGACCAGCTTCTGGCCATTTGTAATGCTGACTTGGGGTGGCACATCTCCCCATCC
  TTCAAGGATCGAGTGGCCCCAGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTGACCGTG
  AACGATACAGGGGAGTACTTCTGCATCTATCACACCTACCCTGATGGGACGTACACTGGG
  AGAATCTTCCTGGAGGTCCTAGAAAGCTCAGTGGCTGAGCACGGTGCCAGGTTCCAGATT
  CCATTGCTTGGAGCCATGGCCGCGACGCTGGTGGTCATCTGCACAGCAGTCATCGTGGTG
  GTCGCGTTGACTAGAAAGAAGAAAGCCCTCAGAATCCATTCTGTGGAAGGTGACCTCAGG
  AGAAAATCAGCTGGACAGGAGGAATGGAGCCCCAGTGCTCCCTCACCCCCAGGAAGCTGT
  GTCCAGGCAGAAGCTGCACCTGCTGGGCTCTGTGGAGAGCAGCGGGGAGAGGACTGTGCC
  GAGCTGCATGACTACTTCAATGTCCTGAGTTACAGAAGCCTGGGTAACTGCAGCTTCTTC
  ACAGAGACTGGTTAG
  
  Clone variation with respect to NM_173799.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_173799 unedited
  TGTAATACGACCTCACTATAGGGCGGCCGCGATTCGGCACGAGGCAGAAGCATGCGCTGG
  TGTCTCCTCCTGATCTGGGCCCAGGGGCTGAGGCAGGCTCCCCTCGCCTCAGGAATGATG
  ACAGGCACAATAGAAACAACGGGGAACATTTCTGCAGAGAAAGGTGGCTCTATCATCTTA
  CAATGTCACCTCTCCTCCACCACGGCACAAGTGACCCAGGTCAACTGGGAGCAGCAGGAC
  CAGCTTCTGGCCATTTGTAATGCTGACTTGGGGTGGCACATCTCCCCATCCTTCAAGGAT
  CGAGTGGCCCCAGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTGACCGTGAACGATACA
  GGGGAGTACTTCTGCATCTATCACACCTACCCTGATGGGACGTACACTGGGAGAATCTTC
  CTGGAGGTCCTANAAAGCTCAGTGGCTGAGCACGGTGCCAGGTTCCAGATTCCATTGCTT
  GGAGCCATGGCCGCGACGCTGGTGGTCATCTGCACAGCAGTCATCGTGGTGGTCGCGTTG
  ACTAAAAAGAAGAAAGCCCTCAGAATCCATTCTGTGGAAGGTGACCTCAGGAGAAAATAN
  CTNGACAGGAGGAATGGAGCCCCCANTGCTCCCTTACCCCACAGAAACTGGGTCCAAGCA
  AAACCTGCACCTGCTGGGCTCTCTGGGAAAAACACCGGGAAAAGGAATGGGCCCCACCCC
  ACAGAATAACTTAAAGGGCCCGGATAAACAAAACCGGGGGAAAGGGGGTTTTTTCAAAAA
  AAGGGTTAACACCAGGGCGTTTTGTGAGAAAACACTTCTTTTTTCTTTTTTAAAAAAAAT
  AAAAAAAGGGGCCTTCCCCCACTCNNNNTGGGTGGGTGGGGTTATTTTNNNNNNNGGGNN
  NAAAAAAAAAAAAAAAAACCCTCTCTCCTTCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' genomic read for NM_173799 unedited
  TGGCCATTGGCATGGCACTTCCAGGNCCAGGNAAAGCACTGGGGNAGGGTCACAGGGCAT
  GCCACCCGGGCTCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTT
  TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAAGGGTAATATTTTATTTCACCCA
  ATACATCCAAAATATTATCATTTTTGACACACAATATACCAAAACTACTGAAATAGTATT
  CTTATTATTCATATTAAATCCCCAAAATCTAGTGTGATTTTATGCTTATACCAATTATAA
  CAGCACATCTTGATTTAAACTAACCCCATCTTAAGTGGTTGATGGCCACATGTGGAAAGT
  GGCTACGTGGTGGATAGCGCATGTCTCCAGGAATCCAACTATGAAATGGTCTTCTCTGGT
  TCTCAAAGGAAAATCTAGTTCAGTGAGTTCTATTTAAAAAAATTTTTTTCAAATTGAATC
  CCATTTCAGTAACCTGACCCATTTCTAACATCTATAGGCCCTTTTGTATTTTATCACCAT
  CCCAATAGTGTTTATAAATGTTTCCCAATTACCATAATTATGTTAAATAACACCCAACTC
  TCAATCCAACCTCTGCCGAATATACACCTCCTCCAAATCAAAACACTACCCCCTTTTCGT
  CATTACTTTTTAGTTTACTTCCCTTTTGGGAATTGTGGTCCATTTCCCCCGGGTTTGCAC
  CTNTTTTTGCNGGAAAATGGCTGGAACCGCCCCAGCCAAAAAACCACTTTTTTCCCGTCC
  CCNAACCTTTTCCCCCNGGGGTCTGGGGCCCTGGGCCNNTTTNNNTTTCTTCTCCCCCGG
  GNNCCCCTTTTGGGGNNNNNGGGNNNNNNGTNTNNCNNNNNANCCCCCCGGGAAAAAATT
  TTATATTAAGCTAAAAAAAAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_173799
• ORF Size: 735 bp
• Insert Size: 3100
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_173799.2, NP_776160.1
• RefSeq Size: 2139
• RefSeq ORF: 735
• Locus ID: 201633
• Protein Families: Transmembrane
• Gene Summary: This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. [provided by RefSeq, Sep 2009]