ADAM22 (NM_021723) Human Untagged Clone

CAT#: SC124720

ADAM22 (untagged)-Human ADAM metallopeptidase domain 22 (ADAM22), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ADAM22
• Synonyms: ADAM 22; EIEE61; MDC2
• Vector: PCMV6-Neo
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_021723, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCAGGCGGCAGTGGCTGTGTCCGTGCCCTTCTTGCTGCTCTGTGTCCTGGGGACCTGCCCTCCGGCGC
  GCTGCGGCCAGGCAGGAGACGCCTCATTGATGGAGCTAGAGAAGAGGAAGGAAAACCGCTTCGTGGAGCG
  CCAGAGCATCGTGCCACTGCGCCTCATCTACCGCTCGGGCGGCGAAGACGAAAGTCGGCACGACGCGCTC
  GACACGCGGGTGCGGGGCGACCTCGGTGGCCCGCAGTTGACTCATGTTGACCAAGCAAGCTTCCAGGTTG
  ATGCCTTTGGAACGTCATTCATTCTCGATGTCGTGCTAAATCATGATTTGCTGTCCTCTGAATACATAGA
  GAGACACATTGAACATGGAGGCAAGACTGTGGAAGTTAAAGGAGGAGAGCACTGTTACTACCAGGGCCAT
  ATCCGAGGAAACCCTGACTCATTTGTTGCATTGTCAACATGCCACGGACTTCATGGGATGTTCTATGACG
  GGAACCACACATATCTCATTGAGCCAGAAGAAAATGACACTACTCAAGAGGATTTCCATTTTCATTCAGT
  TTACAAATCCAGACTGTTTGAATTTTCCTTGGATGATCTTCCATCTGAATTTCAGCAAGTAAACATTACT
  CCATCAAAATTTATTTTGAAGCCAAGACCAAAAAGGAGTAAACGGCAGCTTCGTCGATATCCTCGTAATG
  TAGAAGAAGAAACCAAATACATTGAACTGATGATTGTGAATGATCACCTTATGTTTAAAAAACATCGGCT
  TTCCGTTGTACATACCAATACCTATGCGAAATCTGTGGTGAACATGGCAGATTTAATATATAAAGACCAA
  CTTAAGACCAGGATAGTATTGGTTGCTATGGAAACCTGGGCGACTGACAACAAGTTTGCCATATCTGAAA
  ATCCATTGATCACCCTACGTGAGTTTATGAAATACAGGAGGGATTTTATCAAAGAGAAAAGTGATGCAGT
  TCACCTTTTTTCGGGAAGTCAATTTGAGAGTAGCCGGAGCGGGGCAGCTTATATTGGTGGGATTTGCTCG
  TTGCTGAAAGGAGGAGGCGTGAATGAATTTGGGAAAACTGATTTAATGGCTGTTACACTTGCCCAGTCAT
  TAGCCCATAATATTGGTATTATCTCAGACAAAAGAAAGTTAGCAAGTGGTGAATGTAAATGCGAGGACAC
  GTGGTCCGGGTGCATAATGGGAGACACTGGCTATTATCTTCCTAAAAAGTTCACCCAGTGTAATATTGAA
  GAGTATCATGACTTCCTGAATAGTGGAGGTGGTGCCTGCCTTTTCAACAAACCTTCTAAGCTTCTTGATC
  CTCCTGAGTGTGGCAATGGCTTCATTGAAACTGGAGAGGAGTGTGATTGTGGAACCCCGGCCGAATGTGT
  CCTTGAAGGAGCAGAGTGTTGTAAGAAATGCACCTTGACTCAAGACTCTCAATGCAGTGACGGTCTTTGC
  TGTAAAAAGTGCAAGTTTCAGCCTATGGGCACTGTGTGCCGAGAAGCAGTAAATGATTGTGATATTCGTG
  AAACGTGCTCAGGAAATTCAAGCCAGTGTGCCCCTAATATTCATAAAATGGATGGATATTCATGTGATGG
  TGTTCAGGGAATTTGCTTTGGAGGAAGATGCAAAACCAGAGATAGACAATGCAAATACATTTGGGGGCAA
  AAGGTGACAGCATCAGACAAATATTGCTATGAGAAACTGAATATTGAAGGGACGGAGAAGGGTAACTGTG
  GGAAAGACAAAGACACATGGATACAGTGCAACAAACGGGATGTGCTTTGTGGTTACCTTTTGTGTACCAA
  TATTGGCAATATCCCAAGGCTTGGAGAACTCGATGGTGAAATCACATCTACTTTAGTTGTGCAGCAAGGA
  AGAACATTAAACTGCAGTGGTGGGCATGTTAAGCTTGAAGAAGATGTAGATCTTGGCTATGTGGAAGATG
  GGACACCTTGTGGTCCCCAAATGATGTGCTTAGAACACAGGTGTCTTCCTGTGGCTTCTTTCAACTTTAG
  TACTTGCTTGAGCAGTAAAGAAGGCACTATTTGCTCAGGAAATGGAGTTTGCAGTAATGAGCTGAAGTGT
  GTGTGTAACAGACACTGGATAGGTTCTGATTGCAACACTTACTTCCCTCACAATGATGATGCAAAGACTG
  GTATCACTCTGTCTGGCAATGGTGTTGCTGGCACCAATATCATAATAGGCATAATTGCTGGCACCATTTT
  AGTGCTGGCCCTCATATTAGGAATAACTGCGTGGGGTTATAAAAACTATCGAGAACAGAGACAGTTACCC
  CAGGGAGATTATGTAAAAAAGCCTGGAGATGGTGACTCTTTTTATAGCGACATTCCTCCCGGAGTCAGCA
  CAAACTCAGCATCTAGTTCTAAGAAGAGGTCAAATGGGCTCTCTCATTCTTGGAGTGAAAGGATTCCAGA
  CACAAAACATATTTCAGACATCTGTGAAAATGGGCGACCTCGAAGTAACTCTTGGCAAGGTAACCTGGGA
  GGCAACAAAAAGAAAATCAGAGGCAAAAGATTTAGACCTCGGTCTAATTCAACTGAGACTTTATCTCCTG
  CCAAGTCTCCTTCTTCATCAACTGGGTCTATTGCCTCCAGCAGAAAATACCCTTACCCAATGCCTCCACT
  TCCTGATGAGGACAAGAAAGTGAACCGACAAAGTGCCAGGCTATGGGAGACATCCATTTAA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_021723 unedited
  ACGAGGGTCCGCGAAGCACAATGCAGCACTGAGCCGCGGTGGAGGTTGCAGCGCCACGGC
  CGCCGCAGCACCGGCCGGGGCTGGGTGGAGGTGGCCGCGGGGACCCCGGGGGCGCGGAGC
  GAGGGAAACGGACTCGGCGGCGCCGGCATGAGGAGCTGAGCGTCTCGGGCGAGGCGGGCT
  GACGGCAGCACCATGCAGGCGGCAGTGGCTGTGTCCGTGCCCTTCTTGCTGCTCTGTGTC
  CTGGGGACCTGCCCTCCGGCGCGCTGCGGCCAGGCAGGAGACGCCTCATTGATGGAGCTA
  GAGAAGAGGAAGGAAAACCGCTTCGTGGAGCGCCAGAGCATCGTGCCACTGCGCCTCATC
  TACCGCTCGGGCGGCGAAGACGAAAGTCGGCACGACGCGCTCGACACGCGGGTGCGGGGC
  GACCTCGGTGGCCCGCAGTTGACTCATGTTGACCAAGCAAGCTTCCAGGTTGATGCCTTT
  GGAACGTCATTCATTCTCGATGTCGTGCTAAATCATGATTTGCTGTCCTCTGAATACATA
  GAGAGACACATTGAACATGGAGGCAAGACTGTGGAAGTTAAAGGAGGAGAGCACTGGTTA
  CTACCAGGCCATATCCGAGGAAACCCTGACTCATTTGTTGCATTGTCAACATGCCACGGA
  CTTCATGGGATGTTCTATGACGGGGACCACACATATCTCATTGAGCCCAGAGAAAATGAC
  ACTACTCAAGAGGANTCCCATTTTCATTNCAGTTTACAATCCAGACTGGTTGAATTTTCC
  TTGGATGATCCTCCATCTGAATTTCAGCAAGTAAACATTACTTCCTCCAAATTNATTTTG
  AAGCCCAGACCCAAAAGGAGTAAACGGCCGCTTCGTCGATATTCTCGTATGTAAAAAA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_021723 unedited
  NTTCTTTGACTATGGACCCGCGGCCGCATNCTAAGATCGAGTTTTTTTTTTTTTTTTTCT
  TGGTAAAAATCACTTTATTTGCTACATCTTTCAATCTGTCTGCCCTTCTGTTCTTGGCTT
  GAGCTATGTGGCAACACTGCCCAACACTCACCCAAACCTTGGCCTGATGGATCGCTTTAT
  GGTCATATCAACAATCACATCCCTTCCTGTCATGAAAAATGCTGTTTTACATTATGTAAT
  TTTGGATCATTAAATTGCTTTCCAAACATTTCAAAGACTTTCAAAAGAGAGGTCCATTAC
  AGAAGACATAAACACACAGTATAAAATGCTGCCTTCTAACTCGGCCCTTCAGTTTGGGCA
  TGATATGTAATCAAATTGATTACATATGAAGATGATATGGATTTTGTCCATGGATACTAT
  GGGAGAGGATCAAATTTAAGAGAGTATATCTGAAAACCTGTCTGCAGATTCCATTCCTCT
  TAAGAACACACAGCAAATGAGGAAATCAGAAGTATACTTCACAGCAGACCATGTGATTGA
  GCCCATCAATCTCCAGCCTCACTAGGGTAGCTAGCTTTCTTTTGGAATGACAGATCTGCC
  ATTATAACAGCTATCAAACTTTGGTTTTAAAGAAGGGCCTTTTAAAATAGAATCTTATTT
  TCCTATGGATTAAAAATATATGTTTCAAAGCATCAGATTCTTCTCCCCACCAGNTGTTAG
  CGCAACTTCGCAGATGCTGCATCTCTGTGGTTTAGATCTAACTTAACCCCTTATGAATGG
  TTGAAGCTGCTCACTTCAACAGTATAATTTCCGTCATCTGCTTCAGAGCCAGGCAGATGA
  CTTGTTGGGATTACATCCCATGACGACAATATTCTTATTAACATGCCAAAGTTGGTTTTG
  TTAAACCAATCATCATTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_021723
• ORF Size: 2721 bp
• Insert Size: 5270
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_021723.2, NP_068369.1
• RefSeq Size: 9334
• RefSeq ORF: 2721
• Locus ID: 53616
• Domains: Reprolysin, DISIN, Pep_M12B_propep, ACR
• Protein Families: Druggable Genome, Protease, Transmembrane
• Gene Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants. [provided by RefSeq, Dec 2010]
  Transcript Variant: This variant (1), also known as epsilon, encodes isoform 1, which is proteolytically processed to generate the mature protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.