PCDHA6 (NM_031849) Human Untagged Clone

CAT#: SC124785

PCDHA6 (untagged)-Human protocadherin alpha 6 (PCDHA6), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PCDHA6
• Synonyms: CNR2; CNRN2; CNRS2; CRNR2; PCDH-ALPHA6
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_031849, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGTGTTTACCCCGGAGGATAGATTGGGAAAGCAATGTCTGCTCCTCCCGCTTCTGCTCCTCGCAGCCT
  GGAAGGTGGGGAGCGGCCAGCTCCACTACTCCGTACCCGAGGAGGCCAAACACGGCACCTTCGTGGGCCG
  GATCGCGCAGGACCTGGGGCTGGAGCTGGCGGAGCTGGTGCCGCGCCTGTTCAGGATGGCCTCCAAAGAC
  CGCGAGGACCTTCTGGAGGTAAATCTGCAGAATGGCATTTTGTTTGTGAATTCTCGGATCGACCGCGAGG
  AGCTGTGCGGGCGGAGCGCGGAGTGCAGCATCCACCTGGAGGTGATCGTGGACAGGCCGCTGCAGGTTTT
  CCATGTGGACGTGGAGGTGAGGGACATTAACGACAACCCGCCCTTGTTCCCGGTAGAGGAACAAAGAGTG
  CTGATTTACGAATCTAGGCTGCCAGATTCTGTGTTTCCACTGGAGGGCGCGTCCGATGCAGATGTTGGCT
  CAAATTCCATCTTAACCTATAAACTCAGTTCTAGCGAATACTTCGGGCTAGATGTGAAAATAAACAGTGA
  TGACAATAAACAAATTGGGCTCTTATTAAAGAAATCCTTGGACAGAGAGGAAGCTCCTGCACACAACTTA
  TTCCTGACAGCCACAGATGGGGGCAAACCTGAGCTCACAGGCACTGTTCAGCTGCTGGTCACAGTGCTGG
  ATGTGAATGATAATGCTCCCACTTTCGAACAGTCTGAATACGAAGTAAGAATATTCGAAAATGCAGACAA
  CGGAACAACAGTTATCAGACTGAATGCTTCTGATCGGGATGAAGGAGCGAATGGGGCAATTTCATATTCT
  TTTAATAGCCTTGTTGCAGCCATGGTTATTGACCACTTTAGCATAGATCGAAATACGGGAGAAATAGTGA
  TTCGGGGTAATTTGGATTTTGAACAAGAAAACTTATACAAAATCCTCATTGACGCCACGGACAAAGGCCA
  TCCTCCCATGGCGGGTCATTGCACCGTTTTAGTGAGAATTTTGGATAAAAATGATAACGTCCCTGAGATA
  GCACTGACTTCCTTATCCTTGCCTGTACGTGAAGACGCTCAATTTGGTACTGTCATCGCCCTAATTAGCG
  TGAACGACCTCGATTCAGGTGCCAACGGGCAGGTGAACTGCTCGCTGACGCCTCACGTCCCTTTCAAGCT
  GGTGTCCACCTTCAAGAATTACTACTCGTTGGTGCTGGACAGTGCCCTGGACCGCGAGAGCGTGTCGGCC
  TATGAGTTGGTGGTAACCGCGCGGGACGGGGGCTCGCCTTCGCTGTGGGCCACCGCCAGCTTGTCTGTGG
  AGGTGGCCGACATGAATGACAATGCTCCGGCGTTCGCGCAGCCCGAGTACACAGTGTTCGTGAAGGAGAA
  CAACCCGCCGGGCTGCCACATCTTCACGGTGTCTGCGCGAGACGCGGACGCGCAGGAGAACGCGCTGGTG
  TCCTACTCGCTGGTGGAGCGGCGGGTGGGCGAGCGCGCGTTGTCGAGCTACATTTCGGTGCACGCGGAGA
  GCGGCAAGGTGTACGCGCTGCAGCCGCTGGACCACGAGGAGCTAGAGCTGCTGCAGTTTCAGCCACGACA
  GCCCAACCCTGACTGGCGTTACTCTGCCTCCCTGAGAGCAGGCATGCACAGCTCTGTGCACCTAGAGGAG
  GCTGGCATTCTACGGGCTGGTCCAGGAGGGCCTGATCAGCAGTGGCCAACAGTATCCAGTGCAACACCAG
  AACCAGAGGCAGGAGAAGTGTCCCCTCCAGTCGGTGCGGGTGTCAACAGCAACAGCTGGACCTTTAAATA
  CGGACCAGGCAACCCCAAACAATCCGGTCCCGGTGAGTTGCCCGACAAATTCATTATCCCAGGATCTCCT
  GCAATCATCTCCATCCGGCAGGAGCCTACTAACAGCCAAATTGACAAAAGTGACTTCATAACCTTCGGCA
  AAAAGGAGGAGACCAAGAAAAAGAAGAAAAAGAAGAAGGGTAACAAGACCCAGGAGAAAAAAGAGAAAGG
  GAACAGCACGACTGACAACAGTGACCAGTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_031849 unedited
  CGGCCGCGACATTCGCACGAGGGCGGACGCAGAAGAAAGGATTAATAAATTCCGGAACAT
  ACAGTATTTTATCTTTATGCGGAAGATCTTCTAATGGAAATAAAACCAGAGGTATTTGAC
  ATGGTGTTTACCCCGGAGGATAGATTGGGAAAGCAATGTCTGCTCCTCCCGCTTCTGCTC
  CTCGCAGCCTGGAAGGTGGGGAGCGGCCAGCTCCACTACTCCGTACCCGAGGAGGCCAAA
  CACGGCACCTTCGTGGGCCGGATCGCGCAGGACCTGGGGCTGGAGCTGGCGGAGCTGGTG
  CCGCGCCTGTTCAGGATGGCCTCCAAAGACCGCGAGGACCTTCTGGAGGTAAATCTGCAG
  AATGGCATTTTGTTTGTGAATTCTCGGATCGACCGCGAGGAGCTGTGCGGGCGGAGCGCG
  GAGTGCAGCATCCACCTGGAGGTGATCGTGGACAGGCCGCTGCAGGTTTTCCATGTGGAC
  GTGGAGGTGAGGGACATTAACGACAACCCGCCCTTGTTCCCGGTAGAGGAACAAAGAGTG
  CTGATTTAGAATCTAGGCTGCAGATTCTGTGTTTCCACTGAGGGCGCGTNCATGCCAAAT
  GTTGGCTCAAATTCATCTTACCTATAAACTAGTTCTACGAATACTTCGGCTTAGATGTGA
  AATAAACAGTGATGACAATAACAAATGGGGCTCTATAAAAAAATCTTTGAAGAAAAGAAA
  CTCTGCCACACTTATTCTGACAGCCAAATGGGGGAAACTGACTACAGACTGTAACTGTGG
  ACAAGNGGGGGGGGGAAAAAAAGCCCCACTTTCAACGCTGTTCCCAATAAAATTTAAAGG
  CAAACGGACACATTTAACATGTTTTTTTNNAAAAAAACAAGGGGAATCTTTTTTTAACCG
  TGGCCGGGGGTGGACCTTTAAAAAAAGAAAAAAAAGGGGGGGA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_031849
• ORF Size: 2061 bp
• Insert Size: 4500
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_031849.1, NP_114037.1
• RefSeq Size: 4495
• RefSeq ORF: 2061
• Locus ID: 56142
• Domains: CA
• Protein Families: Secreted Protein, Transmembrane
• Gene Summary: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (3) utilizes an alternative splice donor site that truncates exon 1. This shortest isoform (3) lacks the transmembrane region and has four complete and one partial cadherin domain. CCDS Note: A downstream start codon is annotated for this CCDS representation because its use is more consistent with the presence of an N-terminal signal peptide in the protein, which is known to contain extracellular cadherin domains. However, it should be noted that an alternative upstream start codon exists, which would result in a protein that is 9 aa longer at the N-terminus and is less likely to contain a signal peptide. The upstream start codon has a weak Kozak signal, so it is possible that leaky scanning by ribosomes will allow the use of the downstream start codon. There is no experimental evidence indicating which start codon is used in vivo.