PTP alpha (PTPRA) (NM_080841) Human Untagged Clone

CAT#: SC124914

PTPRA (untagged)-Human protein tyrosine phosphatase, receptor type, A (PTPRA), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPRA
• Synonyms: HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA; PTPRL2; R-PTP-alpha; RPTPA
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_080841 edited
  GGGCGGCCGCGAATTCGGCACGAGGGGATGATGCAGTTCAAATAACTAAGGACACATGTT
  CAAAGAGCATAATTAACTTTTTAAAAGAAGCTAATAAGCATGGATTCCTGGTTCATTCTT
  GTTCTGCTCGGCAGTGGTCTGATATGTGTCAGTGCCAACAATGCTACCACAGTTGCACCT
  TCTGTAGGAATTACAAGATTAATTAACTCATCAACGGCAGAACCAGTTAAAGAAGAGGCC
  AAAACTTCAAATCCAACTTCTTCACTAACTTCTCTTTCTGTGGCACCAACATTCAGCCCA
  AATATAACTCTGGGACCCACCTATTTAACCACTGTCAATTCTTCAGACTCTGACAATGGG
  ACCACAAGAACAGCAAGCACCAATTCTATAGGCATTACAATTTCACCAAATGGAACGTGG
  CTTCCAGATAACCAGTTCACGGATGCCAGAACAGAACCCTGGGAGGGGAATTCCAGCACC
  GCAGCAACCACTCCAGAAACTTTCCCTCCTTCAGATGAGACACCAATTATTGCGGTGATG
  GTGGCCCTGTCCTCTCTGCTAGTGATCGTGTTTATTATCATAGTTTTGTACATGTTAAGG
  TTTAAGAAATACAAGCAAGCTGGGAGCCATTCCAATTCTTTCCGCTTATCCAACGGCCGC
  ACTGAGGATGTGGAGCCCCAGAGTGTGCCACTTCTGGCCAGATCCCCAAGCACCAACAGG
  AAATACCCACCCCTGCCCGTGGACAAGCTGGAAGAGGAAATTAACCGGAGAATGGCAGAC
  GACAATAAGCTCTTCAGGGAGGAATTCAACGCTCTCCCTGCATGTCCTATCCAGGCCACC
  TGTGAGGCTGCTTCCAAGGAGGAAAACAAGGAAAAAAATCGATATGTAAACATCTTGCCT
  TATGACCACTCTAGAGTCCACCTGACACCGGTTGAAGGGGTTCCAGATTCTGATTACATC
  AATGCTTCATTCATCAACGGCTACCAAGAAAAGAACAAATTCATTGCTGCACAAGGACCA
  AAAGAAGAAACGGTGAATGATTTCTGGCGGATGATCTGGGAACAAAACACAGCCACCATC
  GTCATGGTTACCAACCTGAAGGAGAGAAAGGAGTGCAAGTGCGCCCAGTACTGGCCAGAC
  CAAGGCTGCTGGACCTATGGGAATATTCGGGTGTCTGTAGAGGATGTGACTGTCCTGGTG
  GACTACACAGTACGGAAGTTCTGCATCCAGCAGGTGGGCGACATGACCAACAGAAAGCCA
  CAGCGCCTCATCACTCAGTTCCACTTTACCAGCTGGCCAGACTTTGGGGTGCCTTTTACC
  CCGATCGGCATGCTCAAGTTCCTCAAGAAGGTGAAGGCCTGTAACCCTCAGTATGCAGGG
  GCCATCGTGGTCCACTGCAGTGCAAGTGTAGGGCGTACAGGTACCTTTGTCGTCATTGAT
  GCCATGCTGGACATGATGCATACAGAACGGAAGGTGGACGTGTATGGCTTTGTGAGCCGG
  ATCCGGGCACAGCGCTGCCAGATGGTGCAAACCGATATGCAGTATGTCTTCATATACCAA
  GCCCTTCTGGAGCATTATCTCTATGGAGATACAGAACTGGAAGTGACCTCTCTAGAAACC
  CACCTGCAGAAAATTTACAACAAAATCCCAGGGACCAGCAACAATGGATTAGAGGAGGAG
  TTTAAGAAGTTAACATCAATCAAAATCCAGAATGACAAGATGCGGACTGGAAACCTTCCA
  GCCAACATGAAGAAGAACCGTGTTTTACAGATCATTCCATATGAATTCAACAGAGTGATC
  ATTCCAGTTAAGCGGGGCGAAGAGAATACAGACTATGTGAACGCATCCTTTATTGATGGC
  TACCGGCAGAAGGACTCCTATATCGCCAGCCAGGGCCCTCTTCTCCACACAATTGAGGAC
  TTCTGGCGAATGATCTGGGAGTGGAAATCCTGCTCTATCGTGATGCTAACAGAACTGGAG
  GAGAGAGGCCAGGAGAAGTGTGCCCAGTACTGGCCATCTGATGGACTGGTGTCCTATGGA
  GATATTACAGTGGAACTGAAGAAGGAGGAGGAATGTGAGAGCTACACCGTCCGAGACCTC
  CTGGTCACCAACACCAGGGAGAATAAGAGCCGGCAGATCCGGCAGTTCCACTTCCATGGC
  TGGCCTGAAGTGGGCATCCCCAGTGACGGAAAGGGCATGATCAGCATCATCGCCGCCGTG
  CAGAAGCAGCAGCAGCAGTCAGGGAACCACCCCATCACCGTGCACTGCAGCGCCGGGGCA
  GGAAGGACGGGGACCTTCTGTGCCCTGAGCACCGTCCTGGAGCGTGTGAAAGCAGAGGGG
  ATTTTGGATGTCTTCCAGACTGTCAAGAGCCTGCGGCTACAGAGGCCACACATGGTCCAG
  ACACTGGAACAGTATGAGTTCTGCTACAAGGTGGTGCAGGAGTATATTGATGCATTCTCA
  GATTATGCCAACTTCAAGTAAGCGGCAACAAGGGTCCGTGGACCAGGAGGATTGCCTTTA
  ATATTTTGTAATATTCTGTTTTGTTAATATACCCCAAATTGTGTATATATCTTATAACTG
  TTTTAGAAATTGGTACATAGGCTTCTATTACCTATTAGGTGGAAATTTTATATGTAAATG
  TGTTAGCACTGATAGTCCTTTTTCCAATGTTTTATTGGGGAATTAAATAGTGTGATGTTT
  GGATTGATATCGTGAAATCCTCAGCCGAGAAATTGGGCTGGATTGTGCTTTGGTTAATAC
  ATCTTTCCCTAAAGAAGATAAACACAAAATCCATTTCAGGTAGCTCGGCACCAACTAAGA
  AAAAAAGCACAAAGTTCTCAGAGCTCTCGAGGAAAGTGGTTGTCCCCGTACCACCATGCA
  CTGTAAATATCCCTCCCCTCTCTCCCTGGTCCCCTCCCCCATCCCCACCACTGATATCAT
  GGGGAGTAATAGGACCAGAGCGGTATCTCTGGCACCACACTAGGGACTATCAGGTAATAA
  AAGCTTTGACTCCCTAAAAAAAAAAAAAAAAAAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_080841 unedited
  GGTGCATATTTTGTATACGACTCATATAGGCGGCCGCGAAATTCGCACGAGGGGATGATG
  CAGTTCAAATAACTAAGGACACATGTTCAAAGAGCATAATTAACTTTTTAAAAGAAGCTA
  ATAAGCATGGATTCCTGGTTCATTCTTGTTCTGCTCGGCAGTGGTCTGATATGTGTCAGT
  GCCAACAATGCTACCACAGTTGCACCTTCTGTAGGAATTACAAGATTAATTAACTCATCA
  ACGGCAGAACCAGTTAAAGAAGAGGCCAAAACTTCAAATCCAACTTCTTCACTAACTTCT
  CTTTCTGTGGCACCAACATTCAGCCCAAATATAACTCTGGGACCCACCTATTTAACCACT
  GTCAATTCTTCAGACTCTGACAATGGGACCACAAGAACAGCAAGCACCAATTCTATAGGC
  ATTACAATTTCACCAAATGGAACGTGGCTTCCAGATAACCAGTTCACGGATGCCAGAACA
  GAACCCTGGGAGGGGAATTCCAGCACCGCAGCAACCACTCCAGAAACTTTCCCTCCTTCA
  GATGAGACACCAATTATTGCGGTGATGGTGGCCCTGTCCTCTCTGCTAGTGATCGTGTTT
  ATTATCATAGTTTTGTACATGTTAAGGTTTAAGAAATACAAGCAAGCTGGGAGCCATTCC
  AATTCTTTCCGCTTATCCAACGGCCGCACTGAGGATGTGGAGCCCCAGAGTGTGCCACTT
  CTGGCCAGATCCCCAAGCACCAACAGGAAATACCCACCCCTGCCCGTGGACAAGCTGGAA
  AGAGAAATTACCNGAGAATGGCAGACGACAATAAGCTCTTCAGGGAGGAATTCACGCTCT
  NCCTGCATGTNCTATCCAGGCCACCTGTGAAGCTGCTTNCAAGGAGGAAAACANGNNAAA
  AATCGATATGTAAACATCTGCCTAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_080841 unedited
  TATGGAACCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTAGGGAGTCAAA
  GCTTTTATTACCTGATAGTCCCTAGTGTGGTGCCAGAGATACCGCTCTGGTCCTATTACT
  CCCCATGATATCAGTGGTGGGGATGGGGGAGGGGACCAGGGAGAGAGGGGAGGGATATTT
  ACAGTGCATGGTGGTACGGGGACAACCACTTTCCTCGAGAGCTCTGAGAACTTTGTGCTT
  TTTTTCTTAGTTGGTGCCGAGCTACCTGAAATGGATTTTGTGTTTATCTTCTTTAGGGAA
  AGATGTATTAACCAAAGCACAATCCAGCCCAATTTCTCGGCTGAGGATTTCACGATATCA
  ATCCAAACATCACACTATTTAATTCCCCAATAAAACATTGGAAAAAGGACTATCAGTGCT
  AACACATTTACATATAAAATTTCCACCTAATAGGTAATAGAAGCCTATGTACCAATTTCT
  AAAACAGTTATAAGATATATACACAATTTGGGGTATATTAACAAAACAGAATATTACAAA
  ATATTAAAGGCAATCCTCCTGGTCCACGGACCCTTGTTGCCGCTTACTTGAAGTTGGCAT
  AATCTGAGAATGCATCAATATACTCCTGCACCACCTTGTAGCAGAACTCATACTGTTCCA
  GTGTCTGGACCATGTGTGGCCTCTGTAGCCGCAGGCTCTTGACAGTCTGGAAGACATCCA
  AAATCCCCTCTGCTTTCACACGCTCCAGGACGGTGCTCANGGCACAGAANGGTCCCGTCC
  TTTCTGCCCCCGCGCTGCANTGCACGGTGATGGGGGTGGGTCCCTGACTGCTGCTGCTGC
  TTCTGCACGGCGGCGATGATGCTGATCATGCCCTTTCCGTCACTGGGGATGCCCACTTCA
  GCCCANCCTGGGAATGGGACTGGCCGGTCTGCCGGCTCTTATCTTCCTGGGGTGGTGCAC
  ACGAAGTCTTGACCGGGAGCTTTTAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_080841
• Insert Size: 3200 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_080841.1, NP_543031.1
• RefSeq Size: 3148 bp
• RefSeq ORF: 2382 bp
• Locus ID: 5786
• Cytogenetics: 20p13
• Domains: Y_phosphatase
• Protein Families: Druggable Genome, Phosphatase, Transmembrane
• Gene Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]'
  Transcript Variant: This variant (3) contains an additional exon within the 5' UTR, and lacks an internal coding exon, when compared to variant 1. The resulting isoform (2) lacks a 9 aa internal segment, as compared to isoform 1.