MARCKS (NM_002356) Human Untagged Clone

CAT#: SC125313

MARCKS (untagged)-Human myristoylated alanine-rich protein kinase C substrate (MARCKS)


  "NM_002356" in other vectors (6)

Reconstitution Protocol

USD 660.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol MARCKS
Synonyms 80K-L; MACS; PKCSL; PRKCSL
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC125313 sequence for NM_002356 edited (data generated by NextGen Sequencing)
ATGGGTGCCCAGTTCTCCAAGACCGCAGCGAAGGGAGAAGCCGCCGCGGAGAGGCCTGGG
GAGGCGGCTGTGGCCTCGTCGCCTTCCAAAGCGAACGGACAGGAGAATGGCCACGTGAAG
GTAAACGGCGACGCTTCGCCCGCGGCCGCCGAGTCGGGCGCCAAGGAGGAGCTGCAGGCC
AACGGCAGCGCCCCGGCCGCCGACAAGGAGGAGCCCGCGGCCGCCGGGAGCGGGGCGGCG
TCGCCCTCCGCGGCCGAGAAAGGTGAGCCGGCCGCCGCCGCTGCCCCCGAGGCCGGGGCC
AGCCCGGTAGAGAAGGAGGCCCCCGCGGAAGGCGAGGCTGCCGAGCCCGGCTCGCCCACG
GCCGCGGAGGGAGAGGCCGCGTCGGCCGCCTCCTCGACTTCTTCGCCCAAGGCCGAGGAC
GGGGCCACGCCCTCGCCCAGCAACGAGACCCCGAAAAAAAAAAAGAAGCGCTTTTCCTTC
AAGAAGTCTTTCAAGCTGAGCGGCTTCTCCTTCAAGAAGAACAAGAAGGAGGCTGGAGAA
GGCGGTGAGGCTGAGGCGCCCGCTGCCGAAGGCGGCAAGGACGAGGCCGCCGGGGGCGCA
GCTGCGGCCGCCGCCGAGGCGGGCGCGGCCTCCGGGGAGCAGGCAGCGGCGCCGGGCGAG
GAGGCGGCAGCGGGCGAGGAGGGGGCGGCGGGTGGCGACCCGCAGGAGGCCAAGCCCCAG
GAGGCCGCTGTCGCGCCAGAGAAGCCGCCCGCCAGCGACGAGACCAAGGCCGCCGAGGAG
CCCAGCAAGGTGGAGGAGAAAAAGGCCGAGGAGGCCGGGGCCAGCGCCGCCGCCTGCGAG
GCCCCCTCCGCCGCCGGGCCCGGCGCGCCCCCGGAGCAGGAGGCAGCCCCCGCGGAGGAG
CCCGCGGCCGCCGCAGCCTCGTCAGCCTGCGCAGCCCCCTCACAGGAGGCCCAGCCCGAG
TGCAGTCCAGAAGCCCCCCCAGCGGAGGCGGCAGAGTAA

Clone variation with respect to NM_002356.5
>OriGene 5' read for NM_002356 unedited
TTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCATTTTCCTCTTGT
CTACAGTGCGGCTACAAATCTGGGATTTTTTTATTACTTCTTTTTTTTTCGAACTACACT
TGGGCTCCTTTTTTGTGCTCGACTTTTCCACCCTTTTTCCCTCCCTCCTGTGCTGCTGCT
TTTTGATCTCTTCGACTAAAATTTTTTTATCCGGAGTGTATTTAATCGGTTCTGTTCTGT
CCTCTCCACCACCCCCACCCCCCTCCCTCCGGTGTGTGTGCCGCTGCCGCTGTTGCCGCC
GCCGCTGCTGCTGCTCGCCCCGTCGTTACACCAACCCGAGGCTCTTTGTTTCCCCTCTTG
GATCTGTTGAGTTTCTTTGTTGAAGAAGCCAGCATGGGTGCCCAGTTCTCCAAGACCGCA
GCGAAGGGAGAAGCCGCCGCGGAGAGGCCTGGGGAGGCGGCTGTGGCCTCGTCGCCTTCC
AAAGCGAACGGACAGGAGAATGGCCACGTGAAGGTAAACGGCGACGCTTCGCCCGCGGCC
GCCGAGTCGGGCGCCAAGGAGGAGCTGCAGGCCAACGGCAGCGCCCCGGCCGCCGACAAG
GAGGAGCCCGCGGCCGCCGGGAGCGGGGCGGCGTCGCCCTCCGCGGCCGAGAAAGGTGAG
CCGGCCGCCGCCGCTGCCCCCGAGGCCGTGGCCAGCCCGGTAGAGAAAGAGGCCCCCGCG
GAGGCGAAGCTGCCGACCCCGCTCGCCCACGTCGCGGAGGGAGAGGCCGCGTCCGCCGCC
TTCTCGACTTCTTCGCCCAGGGCCGAGGACGGGCCCCGCCCTCGCCCAGCACGAGACCCG
GAAAAAAAAAAGAAGCGCTTTTCCTTCAGGAAGTCTTTCAAGCTGAGCGGGCTTTTCCTT
CAGAAGACCANAAAGGAGCTTGGAAAGGCGGGGAGGTTTTAGCC
>OriGene 3' read for NM_002356 unedited
CTCTGCACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTACATTTTATT
CACATTTATTTTTCGCTTTTAGTGTGCTCACAGAAAATTAGAACACCTTAAGCAGGAGTT
TAATAGCAATTTTTGTAAGCAAAGTTACATTCCATCTCTAAGTCAAATTGGTCAAAGCTT
CTCCAGTATTTACAAAACATGATAGACAAGATGCTACACAAAACCATTGCATCTGAAGAT
TTTTTTTCCTTTATTCTCAAAGACGACTGGAAAAGAAAGCATTATCTGCTGTAATCAAAA
ACATACCACAGTATAAACAGTAACCATTCCACTTATCACAGCTTGGTTGAGTTTAAAATT
TGTGTTTTAAAAGGTCCAAGATGACTGCAGTTTTACAAAAATGGGCAGGGTGGAAAGTTG
CAAACTTCATGTGCTTCTGGATATCAAGATTTGTTTTTATACAATAGCCACAGTTAAAAA
CACCCTGCTGGTAATACATAATTACACTTTATTAAGGTCATAAACCAGCAATAAACAATA
AAGCCTATACAACTTGTAGTTCTACTTAATCACTGACTGGTACAGCTAACATGAGATAAG
TGAAAAGTTCCTATGGTTTAAATGAACTGCTAAGACTATGATCGTCTCTTTTTTTTTAAA
TCTGGCCCTTGGAGTCTTTTCTTTTTTCCCCTTTCCTTCTTACCTAAGACTTGTAGGGCC
GGAAACCTGCCTCACAAAAACACGGTCATAACTTTACTTTAAAAAAAAAAAAAAAGACAC
GCTTTACACATTTTCAGGGGCCCCTATTTGGCAATGGTAGGCCCCCTCTATTTGCTCTTG
GGACCCCTATCACCCATTTGAATTCCCTTCTTGACCCCACTCTCCTCATATATGCCAGGC
CTATATGACAAAAAGTTTCCCTTTTGATCAAGAGCAAGTTGCCCAACCTTATCCGTGCCC
AAAATAAAACAAACAT
Restriction Sites NotI-NotI     
ACCN NM_002356
Insert Size 2560 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_002356.4, NP_002347.4
RefSeq Size 2589 bp
RefSeq ORF 999 bp
Locus ID 4082
Cytogenetics 6q21
Domains MARCKS
Protein Families Druggable Genome
Protein Pathways Fc gamma R-mediated phagocytosis
Gene Summary 'The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]'

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